Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
341032
Gene name Gene Name - the full gene name approved by the HGNC.
POU class 2 homeobox associating factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
POU2AF2
Synonyms (NCBI Gene) Gene synonyms aliases
C11orf53, OCA-T1, OCAT1
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT829969 hsa-miR-1228 CLIP-seq
MIRT829970 hsa-miR-1587 CLIP-seq
MIRT829971 hsa-miR-1910 CLIP-seq
MIRT829972 hsa-miR-3140-5p CLIP-seq
MIRT829973 hsa-miR-329 CLIP-seq
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
620671 30527 ENSG00000150750
Protein
UniProt ID Q8IXP5
Protein name POU domain class 2-associating factor 2 (Oct coactivator from tuft cells 1) (Protein OCA-T1) (POU class 2 homeobox-associating factor 2)
Protein function Transcriptional coactivator of POU2F3 (PubMed:35576971, PubMed:36197978). This complex drives the development of tuft cells, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17721 DUF5566 3 236 Family of unknown function (DUF5566) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in tuft cells of colon mucosa, as well as in small intestine and thymus (PubMed:35576971). {ECO:0000269|PubMed:25048349, ECO:0000269|PubMed:35576971}.
Sequence
Sequence length 236
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 30510241, 31089142
Colorectal cancer Colorectal Carcinoma, Adenocarcinoma of large intestine rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
19011631, 31089142, 30510241
Colorectal neoplasms Colorectal Neoplasms, Malignant neoplasm of large intestine rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
30510241, 31089142
Unknown
Disease term Disease name Evidence References Source
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA