DCDC1 (doublecortin domain containing 1)

Gene

• Entrez ID: 341019
• Gene name: Doublecortin domain containing 1
• Gene symbol: DCDC1
• Synonyms (NCBI Gene): DCDC5
• Chromosome: 11
• Chromosome location: 11p14.1-p13
• Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This g

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT925860	hsa-miR-192	CLIP-seq
MIRT925861	hsa-miR-215	CLIP-seq
MIRT925862	hsa-miR-3616-3p	CLIP-seq
MIRT925863	hsa-miR-3910	CLIP-seq
MIRT925864	hsa-miR-4708-3p	CLIP-seq
MIRT925865	hsa-miR-548a-3p	CLIP-seq
MIRT925866	hsa-miR-548e	CLIP-seq
MIRT925867	hsa-miR-548f	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22159412
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IDA	22159412
GO:0008017	Function	Microtubule binding	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030496	Component	Midbody	IBA
GO:0030496	Component	Midbody	IDA	22159412
GO:0030496	Component	Midbody	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0051301	Process	Cell division	IEA
GO:0072686	Component	Mitotic spindle	IDA	22159412
GO:0090543	Component	Flemming body	IDA	22159412
GO:0090543	Component	Flemming body	IEA
GO:1902412	Process	Regulation of mitotic cytokinesis	IBA
GO:1902412	Process	Regulation of mitotic cytokinesis	IEA
GO:1902412	Process	Regulation of mitotic cytokinesis	IMP	22159412

Other IDs

• MIM: 608062
• HGNC: 20625
• e!Ensembl: ENSG00000170959

Protein

• UniProt ID: M0R2J8
• Protein name: Doublecortin domain-containing protein 1 (Doublecortin domain-containing 5 protein)
• Protein function: Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).
• Sequence:

  MAKTGAEDHREALSQSSLSLLTEAMEVLQQSSPEGTLDGNTVNPIYKYILNDLPREFMSS
  QAKAVIKTTDDYLQSQFGPNRLVHSAAVSEGSGLQDCSTHQTASDHSHDEISDLDSYKSN
  SKNNSCSISASKRNRPVSAPVGQLRVAEFSSLKFQSARNWQKLSQRHKLQPRVIKVTAYK
  NGSRTVFARVTVPTITLLLEECTEKLNLNMAARRVFLADGKEALEPEDIPHEADVYVSTG
  EPFLNPFKKIKDHLLLIKKVTWTMNGLMLPTDIKRRKTKPVLSIRMKKLTERTSVRILFF
  KNGMGQDGHEITVGKETMKKVLDTCTIRMNLNLPARYFYDLYGRKIEDISKVPLLEKCLQ
  NSITPLRGLLWVSKGEGFSPSGAKMYIQGVLLALYQRLKSAKKYYKQLNLVMNEQKEKIT
  EKVILSMTAKEHHKEQEEVSRLIDELQTAIKSNIGHLCKLGPQLQAEQEQFSSYVYQHIK
  SLPANTLVPGGLQLKVFENGKNTGEISVGISKKDLGSDSPIQTDHMMERLLLKIHQRLQG
  SSINPPGLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYGRAYRSPLNLALGLTFDRVSA
  FARGDIMVAYKTFLDPNAVLLPGCGNWEVCEGFPINFNCTSQQIPDQFEKVDLENHFLQN
  KVDPNIVLHASVSIGKWSFSGSEASSRSQIAPSILWPVASVWLITKTGMILSRAITQGCL
  AIGHPIRVKAAEGTSLEGYKLILQKRHSGDDSQKWVFGTDGCIYSKAYPQFVLTYLEELN
  AQVDVTQTEYHIHHGAWTTAHQEHGRNLAEEVLQESASNLGLKQLPEPSDTHLMPEGSLE
  ETGELTVALVRKLEEKHPKASAQRWAIKHEGTSKPGQWKHSRVENPLWNKLTYMWPVLPS
  GQLNEEFDWPIQGLLVPSSPPMKKPICKTTEPYAPVRLRVLQNGEKNKNRSVTILGPDIS
  PGRKTQCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGELWINPDLSIAQQKK
  QIFLRNLESDIAKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAIFGEEKQVTEPEE
  KQMQEDPLTTENASSEILDSHVRAHLRMKACHTLPRYAWQETSHDFDEDDSLPKKTEKGL
  FENVEPQKKHSCSPKHSKLHKHCHQQFEYRDGQIISHAAPQLVLGVQGPNLRSGMEVVLV
  EKKSDGSHQRWIHQEDSRTFHLVSNPDLVLAVSMTKTRNEVCGYPVIVQKYKPYNNGAAN
  QKWHYMKNIKALVAFHSTALDKEITSANYAGVCTSSVIKEENIDQPGYCYLSPDGKRKTM
  LCLACGQSMRTEKGLKQLLPGVPFLCISGTKTQKPFLQGPFKVISVAEVDLSCDKAEKTL
  SYYQARLLSLRMKTCTQAASHSGMAATHQKAVKIIAYKNGDGYRNGKLIVAGTFPMLLTE
  CTEQLGLARAASKVYTKDGTPIFTLRDLVLWALDESFLQRDSEKQKQDAAPVGKEQIIVE
  KNPRMKVKNRLFAKSVTSDSLDGIDKSLLTLILRNPIAIWVSCGEPFLPPNALQKAEKLE
  KQNWLKKDRILADLDTMRHKMRQLKGRRVAACQPATMVPTKSPVQPVVVEGGWTEQTQQE
  IKLMELIRHTEAHLSEIQEMESKINFPIATKRIAVKPSNLYKQPNTKRVWIYLNGGRPED
  GTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKTP
  KELKQLMEIRANYARIRRQQGPQATDIVVSPSTKLLSLAHLHN

• Sequence length: 1783

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
DCDC1-related disorder	Benign; Likely benign	rs16922066, rs11031357, rs199811580, rs143428541, rs80299568, rs289080, rs158633, rs150603680, rs371110864, rs556059169, rs183555899, rs75249430, rs368558006, rs746774392, rs780669727, rs750636009, rs150056724, rs367730942, rs534520626, rs778022600, rs189041969, rs116038359, rs2761591	RCV003963327 RCV003936299 RCV003961155 RCV003929704 RCV003916909 RCV003917023 RCV003977269 RCV003933854 RCV003961654 RCV003941387 RCV003937189 RCV003937232 RCV003957078 RCV003924186 RCV003926764 RCV003927019 RCV003932057 RCV003932154 RCV003917356 RCV003944704 RCV003957179 RCV003968910 RCV003973025
DCDC5-related condition	Benign	rs117396197, rs55719241, rs34110661, rs61747656, rs75606205	RCV004731531 RCV004758744 RCV004758745 RCV004758746 RCV004758748
Familial cancer of breast	Benign	rs158633	RCV005937268
Head and neck cancer	Benign	rs2761591	RCV001004028
Hepatocellular carcinoma	Benign	rs158633	RCV005937269

Associations from Text Mining
Disease Name	Relationship Type	References
Aniridia	Associate	21364908
Esophageal Neoplasms	Associate	29127303
Linitis Plastica	Associate	36450891