APOC1 (apolipoprotein C1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
341
Gene name Gene Name - the full gene name approved by the HGNC.
Apolipoprotein C1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
APOC1
Synonyms (NCBI Gene) Gene synonyms aliases
APOC1B, Apo-CI, ApoC-I, apo-CIB, apoC-IB
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and ve
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT018338 hsa-miR-335-5p Microarray 18185580
MIRT018338 hsa-miR-335-5p Microarray 34081622
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(44)
GO ID Ontology Definition Evidence Reference
GO:0004859 Function Phospholipase inhibitor activity IBA
GO:0004859 Function Phospholipase inhibitor activity IDA 2302419
GO:0005504 Function Fatty acid binding IBA
GO:0005504 Function Fatty acid binding IDA 17339654
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
107710 607 ENSG00000130208
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P02654
Protein name Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I]
Protein function Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoprot
PDB 1ALE , 1ALF , 1IOJ , 1OPP , 6DVU , 6DXR , 6DZ6 , 6NF3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04691 ApoC-I 27 → 82 Apolipoprotein C-I (ApoC-1) Family
Tissue specificity TISSUE SPECIFICITY: Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen. {ECO:0000269|PubMed:2835369}.
Sequence
Sequence length 83
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cholesterol metabolism   VLDL assembly
VLDL clearance
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (10)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Cirrhosis Cirrhosis N/A N/A GWAS
Coronary artery disease Coronary artery disease N/A N/A GWAS
Coronary Heart Disease Coronary heart disease N/A N/A GWAS
Show/Hide Text Mining Associations (68)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acne Vulgaris Associate 29636060
Adenocarcinoma Stimulate 22247499
Adrenocortical Carcinoma Associate 40109215
Alzheimer Disease Associate 19442637, 20298972, 26421299, 26621834, 27805002, 28641921, 29107063, 29432188, 29739406, 29795290, 31346172, 31760383, 31915189, 32539856, 32896012
View all (8 more)
Alzheimer Disease Stimulate 33372590
Atherosclerosis Associate 15808756
Atrophy Associate 31760383
Blood Coagulation Disorders Associate 36136292
Breast Neoplasms Associate 20237941, 21871081, 37268731
Carcinogenesis Associate 36969562