LRIT2 (leucine rich repeat, Ig-like and transmembrane domains 2)

Gene

• Entrez ID: 340745
• Gene name: Leucine rich repeat, Ig-like and transmembrane domains 2
• Gene symbol: LRIT2
• Synonyms (NCBI Gene): LRRC22
• Chromosome: 10
• Chromosome location: 10q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1117745	hsa-miR-1236	CLIP-seq
MIRT1117746	hsa-miR-1237	CLIP-seq
MIRT1117747	hsa-miR-1248	CLIP-seq
MIRT1117748	hsa-miR-1291	CLIP-seq
MIRT1117749	hsa-miR-3125	CLIP-seq
MIRT1117750	hsa-miR-3158-5p	CLIP-seq
MIRT1117751	hsa-miR-3173-5p	CLIP-seq
MIRT1117752	hsa-miR-328	CLIP-seq
MIRT1117753	hsa-miR-365	CLIP-seq
MIRT1117754	hsa-miR-3916	CLIP-seq
MIRT1117755	hsa-miR-4263	CLIP-seq
MIRT1117756	hsa-miR-4314	CLIP-seq
MIRT1117757	hsa-miR-576-5p	CLIP-seq
MIRT2033265	hsa-miR-128	CLIP-seq
MIRT2033266	hsa-miR-148a	CLIP-seq
MIRT2033267	hsa-miR-148b	CLIP-seq
MIRT2033268	hsa-miR-152	CLIP-seq
MIRT2033269	hsa-miR-3907	CLIP-seq
MIRT2033270	hsa-miR-520f	CLIP-seq
MIRT2033271	hsa-miR-636	CLIP-seq
MIRT2033265	hsa-miR-128	CLIP-seq
MIRT2033269	hsa-miR-3907	CLIP-seq
MIRT2263630	hsa-miR-4700-3p	CLIP-seq
MIRT2263631	hsa-miR-4724-3p	CLIP-seq
MIRT2263632	hsa-miR-5095	CLIP-seq
MIRT2562917	hsa-miR-1343	CLIP-seq
MIRT2562918	hsa-miR-4646-5p	CLIP-seq
MIRT2562919	hsa-miR-4790-3p	CLIP-seq
MIRT2562920	hsa-miR-605	CLIP-seq
MIRT2562917	hsa-miR-1343	CLIP-seq
MIRT2562918	hsa-miR-4646-5p	CLIP-seq
MIRT2562919	hsa-miR-4790-3p	CLIP-seq
MIRT2562920	hsa-miR-605	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A6NDA9
• Protein name: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (Leucine-rich repeat-containing protein 22)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	56 → 115	Leucine rich repeat	Repeat
  PF13855	LRR_8	113 → 163	Leucine rich repeat	Repeat
  PF13927	Ig_3	252 → 331		Domain

• Sequence:

  MASVFHYFLLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIPGNLSEEFKQV
  RIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPW
  TAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKC
  RQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPLSKAGQ
  LFHETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDVLT
  SSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDSLSIPS
  EGNAYIDLRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGINTYAV
  DDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVVLLAVPVG
  AYAWAAQGPCSCSKWVLRGCLHRRKAPSCTPAAPQSKDGSFREHPAVCDDGEGHIDTEGD
  KEKGGTEDNS

• Sequence length: 550

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations