Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
340719
Gene name Gene Name - the full gene name approved by the HGNC.
Nanos C2HC-type zinc finger 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NANOS1
Synonyms (NCBI Gene) Gene synonyms aliases
EC_Rep1a, NOS-1, NOS1, SPGF12, ZC2HC12A
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SPGF12
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repr
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs538539239 GCCGCCGCCGCC>-,GCC,GCCGCC,GCCGCCGCC,GCCGCCGCCGCCGCC,GCCGCCGCCGCCGCCGCC,GCCGCCGCCGCCGCCGCCGCC,GCCGCCGCCGCCGCCGCCGCCGCC Pathogenic, benign Inframe deletion, coding sequence variant, inframe insertion
rs587777031 CTCCTCCTC>-,CTCCTC,CTCCTCCTCCTC Conflicting-interpretations-of-pathogenicity Coding sequence variant, inframe deletion, inframe insertion
rs587777767 G>A Pathogenic Coding sequence variant, missense variant
rs587777768 CG>TA Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT037712 hsa-miR-744-5p CLASH 23622248
MIRT611330 hsa-miR-1182 HITS-CLIP 19536157
MIRT611328 hsa-miR-140-3p HITS-CLIP 19536157
MIRT614332 hsa-miR-3119 HITS-CLIP 19536157
MIRT611319 hsa-miR-3692-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth IEA
GO:0001894 Process Tissue homeostasis IEA
GO:0003729 Function MRNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 17047063, 19168546, 21800163, 24736845
GO:0005737 Component Cytoplasm IDA 12690449, 17047063
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608226 23044 ENSG00000188613
Protein
UniProt ID Q8WY41
Protein name Nanos homolog 1 (NOS-1) (EC_Rep1a)
Protein function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadhe
PDB 4CQO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05741 zf-nanos 214 267 Nanos RNA binding domain Family
Tissue specificity TISSUE SPECIFICITY: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed durin
Sequence
MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGE
PRFGCARGGNGGGGSPPSSSSSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRG
RYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATTTSEAT
PREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVL
CPVLRRYTCPLCGASGDNAHTIKYCPL
SKVPPPPARPPPRSARDGPPGKKLR
Sequence length 292
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Azoospermia Azoospermia rs200969445, rs144567652, rs765353898
Male infertility Male infertility with azoospermia or oligozoospermia due to single gene mutation rs554675432, rs9332971, rs397507505, rs797045116, rs748618094, rs781431741, rs1555979575, rs377581367
Non-obstructive azoospermia Non-obstructive azoospermia rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900
Obstructive azoospermia Obstructive azoospermia rs121909016, rs121908805, rs144055758, rs397508761
Unknown
Disease term Disease name Evidence References Source
Spermatogenic Failure spermatogenic failure 12 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Infertility Associate 32344590
Mouth Neoplasms Associate 38401491
Neoplasm Metastasis Associate 36012673
Neoplasms Associate 36012673
Neurodegenerative Diseases Associate 32319615