Gene Gene information from NCBI Gene database.
Entrez ID 340481
Gene name ZDHHC palmitoyltransferase 21
Gene symbol ZDHHC21
Synonyms (NCBI Gene)
DHHC-21DHHC21DNZ1HSPC097
Chromosome 9
Chromosome location 9p22.3
miRNA miRNA information provided by mirtarbase database.
750
miRTarBase ID miRNA Experiments Reference
MIRT651303 hsa-miR-5571-5p HITS-CLIP 19536157
MIRT324663 hsa-miR-888-5p HITS-CLIP 19536157
MIRT721908 hsa-miR-203b-5p HITS-CLIP 19536157
MIRT721906 hsa-miR-6718-5p HITS-CLIP 19536157
MIRT721907 hsa-miR-140-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0001942 Process Hair follicle development IEA
GO:0003056 Process Regulation of vascular associated smooth muscle contraction IEA
GO:0003056 Process Regulation of vascular associated smooth muscle contraction ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614605 20750 ENSG00000175893
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IVQ6
Protein name Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 21) (DHHC-21) (Zinc finger DHHC domain-containing protein 21)
Protein function Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:22031296). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane (
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01529 DHHC 85 218 DHHC palmitoyltransferase Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16647879}.
Sequence
MGLRIHFVVDPHGWCCMGLIVFVWLYNIVLIPKIVLFPHYEEGHIPGILIIIFYGISIFC
LVALVRASITDPGRLPENPKIPHGEREFWELCNKCNLMRPKRSHHCSRCGHCVRRMDHHC
PWINNCVGEDNHWLFLQLCFYTELLTCYALMFSFCHYYYFLPLKKRNLDLFVFRHELAIM
RLAAFMGITMLVGITGLFYTQLIGIITDTTSIEKMSNC
CEDISRPRKPWQQTFSEVFGTR
WKILWFIPFRQRQPLRVPYHFANHV
Sequence length 265
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    eNOS activation
Extra-nuclear estrogen signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CEREBRAL ATHEROSCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DYSLEXIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Osteosarcoma Associate 34922489
★☆☆☆☆
Found in Text Mining only