AGBL3 (AGBL carboxypeptidase 3)

Gene

• Entrez ID: 340351
• Gene name: AGBL carboxypeptidase 3
• Gene symbol: AGBL3
• Synonyms (NCBI Gene): CCP3
• Chromosome: 7
• Chromosome location: 7q33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044918	hsa-miR-186-5p	CLASH	23622248
MIRT495744	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT495743	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT495742	hsa-miR-4717-5p	PAR-CLIP	22291592
MIRT495741	hsa-miR-15a-3p	PAR-CLIP	22291592
MIRT495740	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT495739	hsa-miR-330-3p	PAR-CLIP	22291592
MIRT495738	hsa-miR-5704	PAR-CLIP	22291592
MIRT495744	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT495743	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT495742	hsa-miR-4717-5p	PAR-CLIP	22291592
MIRT495741	hsa-miR-15a-3p	PAR-CLIP	22291592
MIRT495740	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT495739	hsa-miR-330-3p	PAR-CLIP	22291592
MIRT495738	hsa-miR-5704	PAR-CLIP	22291592
MIRT495744	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT495743	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT495742	hsa-miR-4717-5p	PAR-CLIP	22291592
MIRT495741	hsa-miR-15a-3p	PAR-CLIP	22291592
MIRT495740	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT495739	hsa-miR-330-3p	PAR-CLIP	22291592
MIRT495738	hsa-miR-5704	PAR-CLIP	22291592
MIRT495744	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT495743	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT495742	hsa-miR-4717-5p	PAR-CLIP	22291592
MIRT495741	hsa-miR-15a-3p	PAR-CLIP	22291592
MIRT495740	hsa-miR-1295b-3p	PAR-CLIP	22291592
MIRT495739	hsa-miR-330-3p	PAR-CLIP	22291592
MIRT495738	hsa-miR-5704	PAR-CLIP	22291592
MIRT2168564	hsa-miR-128	CLIP-seq
MIRT2168565	hsa-miR-1298	CLIP-seq
MIRT2168566	hsa-miR-205	CLIP-seq
MIRT2168567	hsa-miR-27a	CLIP-seq
MIRT2168568	hsa-miR-27b	CLIP-seq
MIRT2168569	hsa-miR-362-5p	CLIP-seq
MIRT2168570	hsa-miR-4277	CLIP-seq
MIRT2168571	hsa-miR-500b	CLIP-seq
MIRT2168572	hsa-miR-501-5p	CLIP-seq
MIRT2168573	hsa-miR-513a-5p	CLIP-seq
MIRT2443303	hsa-miR-3919	CLIP-seq
MIRT2443304	hsa-miR-4756-3p	CLIP-seq
MIRT2443305	hsa-miR-587	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004180	Function	Carboxypeptidase activity	IEA
GO:0004181	Function	Metallocarboxypeptidase activity	IBA
GO:0004181	Function	Metallocarboxypeptidase activity	IDA	17244817, 25103237
GO:0004181	Function	Metallocarboxypeptidase activity	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005814	Component	Centriole	IBA
GO:0005829	Component	Cytosol	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0015630	Component	Microtubule cytoskeleton	IBA
GO:0015631	Function	Tubulin binding	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0035610	Process	Protein side chain deglutamylation	IDA	25103237
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 617346
• HGNC: 27981
• e!Ensembl: ENSG00000146856

Protein

• UniProt ID: Q8NEM8
• Protein name: Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3) (Protein deglutamylase CCP3)
• Protein function: Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18027	Pepdidase_M14_N	171 → 298	Cytosolic carboxypeptidase N-terminal domain	Domain
  PF00246	Peptidase_M14	318 → 559	Zinc carboxypeptidase	Domain

• Sequence:

  MSEDSEKEDYSDRTISDEDESDEDMFMKFVSEDLHRCALLTADSFGDPFFPRTTQILLEY
  QLGRWVPRLREPRDLYGVSSSGPLSPTRWPYHCEVIDEKVQHIDWTPSCPEPVYIPTGLE
  TEPLYPDSKEATVVYLAEDAYKEPCFVYSRVGGNRTPLKQPVDYRDNTLMFEARFESGNL
  QKVVKVAEYEYQLTVRPDLFTNKHTQWYYFQVTNMRAGIVYRFTIVNFTKPASLYSRGMR
  PLFYSEKEAKAHHIGWQRIGDQIKYYRNNPGQDGRHYFSLTWTFQFPHNKDTCYFAHCYP
  YTYTNLQEYLSGINNDPVRSKFCKIRVLCHTLARNMVYILTITTPLKNSDSRKRKAVILT
  ARVHPGETNSSWIMKGFLDYILGNSSDAQLLRDTFVFKVVPMLNPDGVIVGNYRCSLAGR
  DLNRNYTSLLKESFPSVWYTRNMVHRLMEKREVILYCDLHGHSRKENIFMYGCDGSDRSK
  TLYLQQRIFPLMLSKNCPDKFSFSACKFNVQKSKEGTGRVVMWKMGIRNSFTMEATFCGS
  TLGNKRGTHFSTKDLESMGYHFCDSLLDYCDPDRTKYYRCLKELEEMERHITLEKVFEDS
  DTPVIDITLDVESSSRGSDSSESIDSLTYLLKLTSQKKHLKTKKERNSTIASHQNARGQE
  VYDRGHLLQRHTQSNSDVKDTRPNEPDDYMVDYFRRQLPNQGLAHCKLRLPGSRHSPASA
  SRVAGTTGTRHHTWLIFVFLVEMGKKIPLKGTDLYGNCFKVTSLQSPMGKQTSTWTEKTR
  IPTEDLHHNLKSKIKECISFQSKKTGINWTDDEKRSYKDKGIVQTQEILQYLLPIVHSTK
  NMQTTQIKQLFNPRTNFQIQHQLNPATCRNIKKYSTSWTAPRNHPFVIQGDVMANSSEWV
  QSKPHRSLESLSPLKGPKKNKHSQIWAIKNEDIKPLSSKWETASSSFGMDANVLKYKSLQ
  AEETNQQSSKHTALHLTKNKDEQANKNDGQPTLYLKFQRES

• Sequence length: 1001

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Meningioma	Associate	32949309	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	32949309	★☆☆☆☆ Found in Text Mining only