MYLK4 (myosin light chain kinase family member 4)

Gene

• Entrez ID: 340156
• Gene name: Myosin light chain kinase family member 4
• Gene symbol: MYLK4
• Synonyms (NCBI Gene): SgK085
• Chromosome: 6
• Chromosome location: 6p25.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT656057	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT656056	hsa-miR-1197	HITS-CLIP	23824327
MIRT656055	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT656054	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT656053	hsa-miR-4530	HITS-CLIP	23824327
MIRT656052	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT656051	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656050	hsa-miR-3117-3p	HITS-CLIP	23824327
MIRT656049	hsa-miR-623	HITS-CLIP	23824327
MIRT656048	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT656047	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT656046	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT656045	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT656044	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT656043	hsa-miR-521	HITS-CLIP	23824327
MIRT656057	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT656056	hsa-miR-1197	HITS-CLIP	23824327
MIRT656055	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT656054	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT656053	hsa-miR-4530	HITS-CLIP	23824327
MIRT656052	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT656051	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656050	hsa-miR-3117-3p	HITS-CLIP	23824327
MIRT656049	hsa-miR-623	HITS-CLIP	23824327
MIRT656048	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT656047	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT656046	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT656045	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT656044	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT656043	hsa-miR-521	HITS-CLIP	23824327
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT1169006	hsa-miR-1208	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT1169008	hsa-miR-145	CLIP-seq
MIRT1169009	hsa-miR-147	CLIP-seq
MIRT1169010	hsa-miR-2467-3p	CLIP-seq
MIRT1169011	hsa-miR-297	CLIP-seq
MIRT1169012	hsa-miR-3064-3p	CLIP-seq
MIRT1169013	hsa-miR-3149	CLIP-seq
MIRT1169014	hsa-miR-3150a-5p	CLIP-seq
MIRT1169015	hsa-miR-3150b-5p	CLIP-seq
MIRT1169016	hsa-miR-3198	CLIP-seq
MIRT1169017	hsa-miR-339-3p	CLIP-seq
MIRT1169018	hsa-miR-3650	CLIP-seq
MIRT1169019	hsa-miR-3911	CLIP-seq
MIRT1169020	hsa-miR-3925-3p	CLIP-seq
MIRT1169021	hsa-miR-4252	CLIP-seq
MIRT1169022	hsa-miR-4303	CLIP-seq
MIRT1169023	hsa-miR-4309	CLIP-seq
MIRT1169024	hsa-miR-432	CLIP-seq
MIRT1169025	hsa-miR-4453	CLIP-seq
MIRT1169026	hsa-miR-452	CLIP-seq
MIRT1169027	hsa-miR-4538	CLIP-seq
MIRT1169028	hsa-miR-4653-3p	CLIP-seq
MIRT1169029	hsa-miR-4676-3p	CLIP-seq
MIRT1169030	hsa-miR-4710	CLIP-seq
MIRT1169031	hsa-miR-4715-3p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT1169034	hsa-miR-4776-3p	CLIP-seq
MIRT1169035	hsa-miR-4792	CLIP-seq
MIRT1169036	hsa-miR-4803	CLIP-seq
MIRT1169037	hsa-miR-485-5p	CLIP-seq
MIRT1169038	hsa-miR-508-5p	CLIP-seq
MIRT1169039	hsa-miR-567	CLIP-seq
MIRT1169040	hsa-miR-599	CLIP-seq
MIRT1169041	hsa-miR-644	CLIP-seq
MIRT1169042	hsa-miR-873	CLIP-seq
MIRT1169043	hsa-miR-889	CLIP-seq
MIRT1169044	hsa-miR-922	CLIP-seq
MIRT2048608	hsa-miR-1207-3p	CLIP-seq
MIRT2048609	hsa-miR-139-3p	CLIP-seq
MIRT2048610	hsa-miR-3607-5p	CLIP-seq
MIRT2048611	hsa-miR-3910	CLIP-seq
MIRT2048612	hsa-miR-3913-3p	CLIP-seq
MIRT2048613	hsa-miR-3922-5p	CLIP-seq
MIRT2048614	hsa-miR-4329	CLIP-seq
MIRT2048615	hsa-miR-4420	CLIP-seq
MIRT2048616	hsa-miR-4491	CLIP-seq
MIRT2048617	hsa-miR-4657	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT2048619	hsa-miR-4747-5p	CLIP-seq
MIRT2048620	hsa-miR-489	CLIP-seq
MIRT2048621	hsa-miR-513a-5p	CLIP-seq
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT2277493	hsa-miR-1273f	CLIP-seq
MIRT2277494	hsa-miR-1275	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT2277495	hsa-miR-148a	CLIP-seq
MIRT2277496	hsa-miR-148b	CLIP-seq
MIRT2277497	hsa-miR-152	CLIP-seq
MIRT2277498	hsa-miR-1909	CLIP-seq
MIRT2277499	hsa-miR-216a	CLIP-seq
MIRT1169010	hsa-miR-2467-3p	CLIP-seq
MIRT2277500	hsa-miR-298	CLIP-seq
MIRT2277501	hsa-miR-3125	CLIP-seq
MIRT2277502	hsa-miR-3135b	CLIP-seq
MIRT2277503	hsa-miR-3184	CLIP-seq
MIRT2277504	hsa-miR-3192	CLIP-seq
MIRT2277505	hsa-miR-3675-5p	CLIP-seq
MIRT2277506	hsa-miR-3689a-3p	CLIP-seq
MIRT2277507	hsa-miR-3689c	CLIP-seq
MIRT2277508	hsa-miR-3916	CLIP-seq
MIRT2277509	hsa-miR-423-5p	CLIP-seq
MIRT2277510	hsa-miR-4434	CLIP-seq
MIRT2277511	hsa-miR-4457	CLIP-seq
MIRT2277512	hsa-miR-4516	CLIP-seq
MIRT2277513	hsa-miR-4525	CLIP-seq
MIRT2277514	hsa-miR-4531	CLIP-seq
MIRT2277515	hsa-miR-4537	CLIP-seq
MIRT2277516	hsa-miR-4665-5p	CLIP-seq
MIRT2277517	hsa-miR-4688	CLIP-seq
MIRT2277518	hsa-miR-4691-3p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT2277519	hsa-miR-4723-5p	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT2277520	hsa-miR-4731-3p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT2277521	hsa-miR-4801	CLIP-seq
MIRT2277522	hsa-miR-4802-3p	CLIP-seq
MIRT1169037	hsa-miR-485-5p	CLIP-seq
MIRT2277523	hsa-miR-486-3p	CLIP-seq
MIRT2277524	hsa-miR-490-3p	CLIP-seq
MIRT2277525	hsa-miR-625	CLIP-seq
MIRT2277526	hsa-miR-637	CLIP-seq
MIRT2277527	hsa-miR-658	CLIP-seq
MIRT2277528	hsa-miR-720	CLIP-seq
MIRT2391255	hsa-miR-140-3p	CLIP-seq
MIRT2391256	hsa-miR-15a	CLIP-seq
MIRT2391257	hsa-miR-15b	CLIP-seq
MIRT2391258	hsa-miR-16	CLIP-seq
MIRT2391259	hsa-miR-195	CLIP-seq
MIRT2391260	hsa-miR-3176	CLIP-seq
MIRT2391261	hsa-miR-3922-3p	CLIP-seq
MIRT2391262	hsa-miR-3926	CLIP-seq
MIRT2391263	hsa-miR-424	CLIP-seq
MIRT2391264	hsa-miR-4786-5p	CLIP-seq
MIRT2277522	hsa-miR-4802-3p	CLIP-seq
MIRT2391265	hsa-miR-497	CLIP-seq
MIRT2391266	hsa-miR-548s	CLIP-seq
MIRT2391267	hsa-miR-769-5p	CLIP-seq
MIRT2438829	hsa-miR-548k	CLIP-seq
MIRT2454698	hsa-miR-3148	CLIP-seq
MIRT2454699	hsa-miR-3591-3p	CLIP-seq
MIRT2454700	hsa-miR-3652	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2454702	hsa-miR-3688-3p	CLIP-seq
MIRT2454703	hsa-miR-3978	CLIP-seq
MIRT2454704	hsa-miR-4430	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT2454706	hsa-miR-4694-3p	CLIP-seq
MIRT2454707	hsa-miR-4775	CLIP-seq
MIRT2454708	hsa-miR-539	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT2454710	hsa-miR-875-3p	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT2277493	hsa-miR-1273f	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT2277504	hsa-miR-3192	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2277506	hsa-miR-3689a-3p	CLIP-seq
MIRT2277507	hsa-miR-3689c	CLIP-seq
MIRT2277515	hsa-miR-4537	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT2277524	hsa-miR-490-3p	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT2277527	hsa-miR-658	CLIP-seq
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT2277504	hsa-miR-3192	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2277506	hsa-miR-3689a-3p	CLIP-seq
MIRT2277507	hsa-miR-3689c	CLIP-seq
MIRT2277515	hsa-miR-4537	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT2277524	hsa-miR-490-3p	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT2277527	hsa-miR-658	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004687	Function	Myosin light chain kinase activity	IBA
GO:0005515	Function	Protein binding	IPI	22939624, 28514442, 32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q86YV6
• Protein name: Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)
• PDB: 2X4F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	106 → 361	Protein kinase domain	Domain

• Sequence:

  MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSN
  ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV
  HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM
  EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA
  KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL
  SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW
  LSDHKLHSRLNAQKKKNRGSDAQDFVTK

• Sequence length: 388

Pathways

KEGG:

Calcium signaling pathway
cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Apelin signaling pathway
Focal adhesion
Platelet activation
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Gastric acid secretion

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Long QT syndrome	Likely benign	rs796052168	RCV000190165

Associations from Text Mining
Disease Name	Relationship Type	References
Cardiomyopathies	Associate	24709777
Cardiomyopathy Dilated	Inhibit	24709777