Gene Gene information from NCBI Gene database.
Entrez ID 340152
Gene name Zinc finger CCCH-type containing 12D
Gene symbol ZC3H12D
Synonyms (NCBI Gene)
C6orf95MCPIP4TFLdJ281H8.1p34
Chromosome 6
Chromosome location 6q25.1
miRNA miRNA information provided by mirtarbase database.
626
miRTarBase ID miRNA Experiments Reference
MIRT1505515 hsa-miR-106a CLIP-seq
MIRT1505516 hsa-miR-106b CLIP-seq
MIRT1505517 hsa-miR-1200 CLIP-seq
MIRT1505518 hsa-miR-1207-5p CLIP-seq
MIRT1505519 hsa-miR-1245 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IDA 24415781, 26134560
GO:0000932 Component P-body IEA
GO:0003729 Function MRNA binding IBA
GO:0004518 Function Nuclease activity IEA
GO:0004519 Function Endonuclease activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611106 21175 ENSG00000178199
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A2A288
Protein name Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34)
Protein function May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18039 UBA_6 3 44 UBA-like domain Domain
PF11977 RNase_Zc3h12a 88 244 Zc3h12a-like Ribonuclease NYN domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines. {ECO:0000269|PubMed:19531561}.
Sequence
MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVP
RGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDW
FRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDD
RYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGP
SLSN
FLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPG
AGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGP
PLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPR
DLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARAR
ARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP
Sequence length 527
Interactions View interactions