Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3398
Gene name Gene Name - the full gene name approved by the HGNC.
Inhibitor of DNA binding 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ID2
Synonyms (NCBI Gene) Gene synonyms aliases
GIG8, ID2A, ID2H, bHLHb26
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p25.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit th
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007060 hsa-miR-9-5p Immunoblot, Immunohistochemistry, Luciferase reporter assay, Northern blot, qRT-PCR 22848373
MIRT007062 hsa-miR-103a-3p Immunoblot, Immunohistochemistry, Luciferase reporter assay, Northern blot, qRT-PCR 22848373
MIRT023177 hsa-miR-124-3p Microarray 18668037
MIRT024314 hsa-miR-215-5p Microarray 19074876
MIRT026921 hsa-miR-192-5p Microarray 19074876
Transcription factors
Transcription factor Regulation Reference
FLI1 Activation 12447693
HOXA10 Activation 20565746
HOXA9 Activation 20565746
MYC Unknown 12545167
MYCN Unknown 12670915
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000791 Component Euchromatin ISS
GO:0001102 Function RNA polymerase II activating transcription factor binding ISS
GO:0005515 Function Protein binding IPI 10915743, 14752053, 16311606, 16549780, 19321746, 20861012, 22453338, 25609649, 28514442, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600386 5361 ENSG00000115738
Protein
UniProt ID Q02363
Protein name DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
Protein function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated i
PDB 4AYA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 35 76 Helix-loop-helix DNA-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in early fetal tissues, including those of the central nervous system.
Sequence
MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVS
KMEILQHVIDYILDLQ
IALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEF
PSELMSNDSKALCG
Sequence length 134
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  TGF-beta signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Transcriptional misregulation in cancer
  NGF-stimulated transcription
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 17330099
Lung carcinoma Small cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
23582323
Unknown
Disease term Disease name Evidence References Source
Congenital Heart Disease congenital heart disease GenCC
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 27191723
Anemia Hemolytic Associate 36385258
Arthritis Rheumatoid Inhibit 17393418
Azoospermia Associate 25977194
Barrett Esophagus Stimulate 27191723
Biliary Tract Neoplasms Associate 24409060
Breast Neoplasms Stimulate 30066902
Burkitt Lymphoma Associate 16877363
Calcinosis Cutis Stimulate 20388805
Carcinogenesis Associate 11572874, 23342268, 24343358