CYP27C1 (cytochrome P450 family 27 subfamily C member 1)

Gene

• Entrez ID: 339761
• Gene name: Cytochrome P450 family 27 subfamily C member 1
• Gene symbol: CYP27C1
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2q14.3
• Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSe

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017938	hsa-miR-335-5p	Microarray	18185580
MIRT694150	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT694149	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT694148	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT694147	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT694146	hsa-miR-6128	HITS-CLIP	23313552
MIRT694145	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT694144	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT694143	hsa-miR-6131	HITS-CLIP	23313552
MIRT694142	hsa-miR-4527	HITS-CLIP	23313552
MIRT694141	hsa-miR-6503-5p	HITS-CLIP	23313552
MIRT694140	hsa-miR-6753-3p	HITS-CLIP	23313552
MIRT694139	hsa-miR-7107-3p	HITS-CLIP	23313552
MIRT694138	hsa-miR-1299	HITS-CLIP	23313552
MIRT694137	hsa-miR-548s	HITS-CLIP	23313552
MIRT694136	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT694135	hsa-miR-588	HITS-CLIP	23313552
MIRT694134	hsa-miR-4435	HITS-CLIP	23313552
MIRT694133	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT647154	hsa-miR-4438	HITS-CLIP	23824327
MIRT647153	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT647152	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647151	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT647150	hsa-miR-5193	HITS-CLIP	23824327
MIRT647149	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT647148	hsa-miR-6078	HITS-CLIP	23824327
MIRT647147	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT647146	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT647145	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT647144	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT647143	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT647142	hsa-miR-874-5p	HITS-CLIP	23824327
MIRT647141	hsa-miR-5095	HITS-CLIP	23824327
MIRT647140	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT647139	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT647138	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT647137	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT647136	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT538238	hsa-miR-4418	PAR-CLIP	22012620
MIRT538237	hsa-miR-509-3-5p	PAR-CLIP	22012620
MIRT538236	hsa-miR-509-5p	PAR-CLIP	22012620
MIRT538235	hsa-miR-6854-5p	PAR-CLIP	22012620
MIRT538234	hsa-miR-7705	PAR-CLIP	22012620
MIRT538233	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT538232	hsa-miR-1304-3p	PAR-CLIP	22012620
MIRT538231	hsa-miR-3158-5p	PAR-CLIP	22012620
MIRT538230	hsa-miR-3166	PAR-CLIP	22012620
MIRT538229	hsa-miR-4771	PAR-CLIP	22012620
MIRT538228	hsa-miR-376a-3p	PAR-CLIP	22012620
MIRT538227	hsa-miR-376b-3p	PAR-CLIP	22012620
MIRT538226	hsa-miR-1273h-3p	PAR-CLIP	22012620
MIRT694150	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT694149	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT694148	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT694147	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT694146	hsa-miR-6128	HITS-CLIP	23313552
MIRT694145	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT694144	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT694143	hsa-miR-6131	HITS-CLIP	23313552
MIRT694142	hsa-miR-4527	HITS-CLIP	23313552
MIRT694141	hsa-miR-6503-5p	HITS-CLIP	23313552
MIRT694140	hsa-miR-6753-3p	HITS-CLIP	23313552
MIRT694139	hsa-miR-7107-3p	HITS-CLIP	23313552
MIRT694138	hsa-miR-1299	HITS-CLIP	23313552
MIRT694137	hsa-miR-548s	HITS-CLIP	23313552
MIRT694136	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT694135	hsa-miR-588	HITS-CLIP	23313552
MIRT694134	hsa-miR-4435	HITS-CLIP	23313552
MIRT694133	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT647154	hsa-miR-4438	HITS-CLIP	23824327
MIRT647153	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT647152	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647151	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT647150	hsa-miR-5193	HITS-CLIP	23824327
MIRT647149	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT647148	hsa-miR-6078	HITS-CLIP	23824327
MIRT647147	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT647146	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT647145	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT647144	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT647143	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT647142	hsa-miR-874-5p	HITS-CLIP	23824327
MIRT647141	hsa-miR-5095	HITS-CLIP	23824327
MIRT647140	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT647139	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT647138	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT647137	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT647136	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT538238	hsa-miR-4418	PAR-CLIP	22012620
MIRT538237	hsa-miR-509-3-5p	PAR-CLIP	22012620
MIRT538236	hsa-miR-509-5p	PAR-CLIP	22012620
MIRT538235	hsa-miR-6854-5p	PAR-CLIP	22012620
MIRT538234	hsa-miR-7705	PAR-CLIP	22012620
MIRT538233	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT538232	hsa-miR-1304-3p	PAR-CLIP	22012620
MIRT538231	hsa-miR-3158-5p	PAR-CLIP	22012620
MIRT538230	hsa-miR-3166	PAR-CLIP	22012620
MIRT538229	hsa-miR-4771	PAR-CLIP	22012620
MIRT538228	hsa-miR-376a-3p	PAR-CLIP	22012620
MIRT538227	hsa-miR-376b-3p	PAR-CLIP	22012620
MIRT538226	hsa-miR-1273h-3p	PAR-CLIP	22012620
MIRT921217	hsa-miR-1184	CLIP-seq
MIRT921218	hsa-miR-1224-3p	CLIP-seq
MIRT921219	hsa-miR-132	CLIP-seq
MIRT921220	hsa-miR-140-5p	CLIP-seq
MIRT921221	hsa-miR-147	CLIP-seq
MIRT921222	hsa-miR-150	CLIP-seq
MIRT921223	hsa-miR-15a	CLIP-seq
MIRT921224	hsa-miR-15b	CLIP-seq
MIRT921225	hsa-miR-16	CLIP-seq
MIRT921226	hsa-miR-1915	CLIP-seq
MIRT921227	hsa-miR-194	CLIP-seq
MIRT921228	hsa-miR-195	CLIP-seq
MIRT921229	hsa-miR-1976	CLIP-seq
MIRT921230	hsa-miR-212	CLIP-seq
MIRT921231	hsa-miR-214	CLIP-seq
MIRT921232	hsa-miR-299-5p	CLIP-seq
MIRT921233	hsa-miR-3117-3p	CLIP-seq
MIRT921234	hsa-miR-3127-3p	CLIP-seq
MIRT921235	hsa-miR-3148	CLIP-seq
MIRT921236	hsa-miR-3164	CLIP-seq
MIRT921237	hsa-miR-3169	CLIP-seq
MIRT921238	hsa-miR-3183	CLIP-seq
MIRT921239	hsa-miR-339-5p	CLIP-seq
MIRT921240	hsa-miR-3616-5p	CLIP-seq
MIRT921241	hsa-miR-3619-5p	CLIP-seq
MIRT921242	hsa-miR-3647-5p	CLIP-seq
MIRT921243	hsa-miR-3664-5p	CLIP-seq
MIRT921244	hsa-miR-3688-3p	CLIP-seq
MIRT921245	hsa-miR-371-5p	CLIP-seq
MIRT921246	hsa-miR-371b-5p	CLIP-seq
MIRT921247	hsa-miR-3929	CLIP-seq
MIRT921248	hsa-miR-424	CLIP-seq
MIRT921249	hsa-miR-4277	CLIP-seq
MIRT921250	hsa-miR-4279	CLIP-seq
MIRT921251	hsa-miR-4286	CLIP-seq
MIRT921252	hsa-miR-4419b	CLIP-seq
MIRT921253	hsa-miR-4446-5p	CLIP-seq
MIRT921254	hsa-miR-4468	CLIP-seq
MIRT921255	hsa-miR-4478	CLIP-seq
MIRT921256	hsa-miR-4639-3p	CLIP-seq
MIRT921257	hsa-miR-4653-3p	CLIP-seq
MIRT921258	hsa-miR-4691-5p	CLIP-seq
MIRT921259	hsa-miR-4694-3p	CLIP-seq
MIRT921260	hsa-miR-4714-3p	CLIP-seq
MIRT921261	hsa-miR-4722-3p	CLIP-seq
MIRT921262	hsa-miR-4723-3p	CLIP-seq
MIRT921263	hsa-miR-4726-3p	CLIP-seq
MIRT921264	hsa-miR-4755-5p	CLIP-seq
MIRT921265	hsa-miR-4759	CLIP-seq
MIRT921266	hsa-miR-4792	CLIP-seq
MIRT921267	hsa-miR-4795-5p	CLIP-seq
MIRT921268	hsa-miR-486-5p	CLIP-seq
MIRT921269	hsa-miR-497	CLIP-seq
MIRT921270	hsa-miR-498	CLIP-seq
MIRT921271	hsa-miR-499a-5p	CLIP-seq
MIRT921272	hsa-miR-511	CLIP-seq
MIRT921273	hsa-miR-519a	CLIP-seq
MIRT921274	hsa-miR-519b-3p	CLIP-seq
MIRT921275	hsa-miR-519c-3p	CLIP-seq
MIRT921276	hsa-miR-522	CLIP-seq
MIRT921277	hsa-miR-548ae	CLIP-seq
MIRT921278	hsa-miR-548aj	CLIP-seq
MIRT921279	hsa-miR-548am	CLIP-seq
MIRT921280	hsa-miR-548an	CLIP-seq
MIRT921281	hsa-miR-548x	CLIP-seq
MIRT921282	hsa-miR-562	CLIP-seq
MIRT921283	hsa-miR-573	CLIP-seq
MIRT921284	hsa-miR-599	CLIP-seq
MIRT921285	hsa-miR-670	CLIP-seq
MIRT921286	hsa-miR-761	CLIP-seq
MIRT921287	hsa-miR-766	CLIP-seq
MIRT1547813	hsa-miR-1293	CLIP-seq
MIRT1547814	hsa-miR-3074-5p	CLIP-seq
MIRT1547815	hsa-miR-3173-5p	CLIP-seq
MIRT1547816	hsa-miR-370	CLIP-seq
MIRT1547817	hsa-miR-4325	CLIP-seq
MIRT1547818	hsa-miR-4483	CLIP-seq
MIRT1547819	hsa-miR-4793-3p	CLIP-seq
MIRT1547820	hsa-miR-566	CLIP-seq
MIRT921217	hsa-miR-1184	CLIP-seq
MIRT1547813	hsa-miR-1293	CLIP-seq
MIRT921222	hsa-miR-150	CLIP-seq
MIRT921226	hsa-miR-1915	CLIP-seq
MIRT1972965	hsa-miR-197	CLIP-seq
MIRT921229	hsa-miR-1976	CLIP-seq
MIRT1547814	hsa-miR-3074-5p	CLIP-seq
MIRT1547815	hsa-miR-3173-5p	CLIP-seq
MIRT1972966	hsa-miR-3201	CLIP-seq
MIRT1547816	hsa-miR-370	CLIP-seq
MIRT921245	hsa-miR-371-5p	CLIP-seq
MIRT1972967	hsa-miR-3907	CLIP-seq
MIRT1972968	hsa-miR-4264	CLIP-seq
MIRT921250	hsa-miR-4279	CLIP-seq
MIRT1547817	hsa-miR-4325	CLIP-seq
MIRT1972969	hsa-miR-4423-5p	CLIP-seq
MIRT1547818	hsa-miR-4483	CLIP-seq
MIRT921260	hsa-miR-4714-3p	CLIP-seq
MIRT921261	hsa-miR-4722-3p	CLIP-seq
MIRT921263	hsa-miR-4726-3p	CLIP-seq
MIRT1972970	hsa-miR-4791	CLIP-seq
MIRT1547819	hsa-miR-4793-3p	CLIP-seq
MIRT921270	hsa-miR-498	CLIP-seq
MIRT921271	hsa-miR-499a-5p	CLIP-seq
MIRT1972971	hsa-miR-5096	CLIP-seq
MIRT1972972	hsa-miR-548q	CLIP-seq
MIRT921282	hsa-miR-562	CLIP-seq
MIRT1547820	hsa-miR-566	CLIP-seq
MIRT1972973	hsa-miR-578	CLIP-seq
MIRT1972974	hsa-miR-590-3p	CLIP-seq
MIRT1972975	hsa-miR-622	CLIP-seq
MIRT2208563	hsa-miR-1178	CLIP-seq
MIRT2208564	hsa-miR-1179	CLIP-seq
MIRT2208565	hsa-miR-122	CLIP-seq
MIRT2208566	hsa-miR-1237	CLIP-seq
MIRT2208567	hsa-miR-1248	CLIP-seq
MIRT921222	hsa-miR-150	CLIP-seq
MIRT921226	hsa-miR-1915	CLIP-seq
MIRT1972965	hsa-miR-197	CLIP-seq
MIRT921229	hsa-miR-1976	CLIP-seq
MIRT921233	hsa-miR-3117-3p	CLIP-seq
MIRT2208568	hsa-miR-3124-3p	CLIP-seq
MIRT2208569	hsa-miR-3149	CLIP-seq
MIRT921237	hsa-miR-3169	CLIP-seq
MIRT2208570	hsa-miR-3192	CLIP-seq
MIRT2208571	hsa-miR-3529	CLIP-seq
MIRT921240	hsa-miR-3616-5p	CLIP-seq
MIRT921242	hsa-miR-3647-5p	CLIP-seq
MIRT2208572	hsa-miR-3661	CLIP-seq
MIRT2208573	hsa-miR-3689a-3p	CLIP-seq
MIRT2208574	hsa-miR-3689c	CLIP-seq
MIRT2208575	hsa-miR-379	CLIP-seq
MIRT2208576	hsa-miR-383	CLIP-seq
MIRT921247	hsa-miR-3929	CLIP-seq
MIRT921250	hsa-miR-4279	CLIP-seq
MIRT2208577	hsa-miR-4310	CLIP-seq
MIRT2208578	hsa-miR-4315	CLIP-seq
MIRT921252	hsa-miR-4419b	CLIP-seq
MIRT1972969	hsa-miR-4423-5p	CLIP-seq
MIRT2208579	hsa-miR-4451	CLIP-seq
MIRT921255	hsa-miR-4478	CLIP-seq
MIRT2208580	hsa-miR-4650-3p	CLIP-seq
MIRT2208581	hsa-miR-4695-3p	CLIP-seq
MIRT921261	hsa-miR-4722-3p	CLIP-seq
MIRT921263	hsa-miR-4726-3p	CLIP-seq
MIRT2208582	hsa-miR-4728-5p	CLIP-seq
MIRT2208583	hsa-miR-4735-5p	CLIP-seq
MIRT921265	hsa-miR-4759	CLIP-seq
MIRT2208584	hsa-miR-4772-5p	CLIP-seq
MIRT2208585	hsa-miR-4775	CLIP-seq
MIRT921267	hsa-miR-4795-5p	CLIP-seq
MIRT2208586	hsa-miR-492	CLIP-seq
MIRT921270	hsa-miR-498	CLIP-seq
MIRT2208587	hsa-miR-501-3p	CLIP-seq
MIRT2208588	hsa-miR-502-3p	CLIP-seq
MIRT1972971	hsa-miR-5096	CLIP-seq
MIRT2208589	hsa-miR-512-5p	CLIP-seq
MIRT2208590	hsa-miR-515-5p	CLIP-seq
MIRT921273	hsa-miR-519a	CLIP-seq
MIRT921274	hsa-miR-519b-3p	CLIP-seq
MIRT921275	hsa-miR-519c-3p	CLIP-seq
MIRT921282	hsa-miR-562	CLIP-seq
MIRT921283	hsa-miR-573	CLIP-seq
MIRT1972974	hsa-miR-590-3p	CLIP-seq
MIRT2208591	hsa-miR-631	CLIP-seq
MIRT2208592	hsa-miR-767-5p	CLIP-seq
MIRT2386654	hsa-miR-221	CLIP-seq
MIRT2386655	hsa-miR-222	CLIP-seq
MIRT921240	hsa-miR-3616-5p	CLIP-seq
MIRT921242	hsa-miR-3647-5p	CLIP-seq
MIRT921247	hsa-miR-3929	CLIP-seq
MIRT2386656	hsa-miR-4285	CLIP-seq
MIRT921252	hsa-miR-4419b	CLIP-seq
MIRT921255	hsa-miR-4478	CLIP-seq
MIRT2386657	hsa-miR-4487	CLIP-seq
MIRT921267	hsa-miR-4795-5p	CLIP-seq
MIRT2386658	hsa-miR-499-3p	CLIP-seq
MIRT2386659	hsa-miR-499a-3p	CLIP-seq
MIRT921273	hsa-miR-519a	CLIP-seq
MIRT921274	hsa-miR-519b-3p	CLIP-seq
MIRT921275	hsa-miR-519c-3p	CLIP-seq
MIRT2386660	hsa-miR-548v	CLIP-seq
MIRT921283	hsa-miR-573	CLIP-seq
MIRT2208592	hsa-miR-767-5p	CLIP-seq
MIRT2447903	hsa-miR-204	CLIP-seq
MIRT2447904	hsa-miR-211	CLIP-seq
MIRT2447905	hsa-miR-2115	CLIP-seq
MIRT2208569	hsa-miR-3149	CLIP-seq
MIRT2208571	hsa-miR-3529	CLIP-seq
MIRT2447906	hsa-miR-3667-3p	CLIP-seq
MIRT2447907	hsa-miR-3672	CLIP-seq
MIRT2208575	hsa-miR-379	CLIP-seq
MIRT2447908	hsa-miR-4276	CLIP-seq
MIRT2208579	hsa-miR-4451	CLIP-seq
MIRT2208580	hsa-miR-4650-3p	CLIP-seq
MIRT921263	hsa-miR-4726-3p	CLIP-seq
MIRT2208583	hsa-miR-4735-5p	CLIP-seq
MIRT921264	hsa-miR-4755-5p	CLIP-seq
MIRT2208585	hsa-miR-4775	CLIP-seq
MIRT2447909	hsa-miR-516a-3p	CLIP-seq
MIRT1972974	hsa-miR-590-3p	CLIP-seq
MIRT2447910	hsa-miR-623	CLIP-seq
MIRT2447903	hsa-miR-204	CLIP-seq
MIRT2447904	hsa-miR-211	CLIP-seq
MIRT2447905	hsa-miR-2115	CLIP-seq
MIRT2208569	hsa-miR-3149	CLIP-seq
MIRT2208571	hsa-miR-3529	CLIP-seq
MIRT2447906	hsa-miR-3667-3p	CLIP-seq
MIRT2447907	hsa-miR-3672	CLIP-seq
MIRT2208575	hsa-miR-379	CLIP-seq
MIRT2447908	hsa-miR-4276	CLIP-seq
MIRT2208579	hsa-miR-4451	CLIP-seq
MIRT2208580	hsa-miR-4650-3p	CLIP-seq
MIRT2208583	hsa-miR-4735-5p	CLIP-seq
MIRT921264	hsa-miR-4755-5p	CLIP-seq
MIRT2208585	hsa-miR-4775	CLIP-seq
MIRT2447909	hsa-miR-516a-3p	CLIP-seq
MIRT1972974	hsa-miR-590-3p	CLIP-seq
MIRT2447910	hsa-miR-623	CLIP-seq
MIRT921217	hsa-miR-1184	CLIP-seq
MIRT2208565	hsa-miR-122	CLIP-seq
MIRT2512464	hsa-miR-3135b	CLIP-seq
MIRT2208569	hsa-miR-3149	CLIP-seq
MIRT2208571	hsa-miR-3529	CLIP-seq
MIRT2512465	hsa-miR-3652	CLIP-seq
MIRT2208575	hsa-miR-379	CLIP-seq
MIRT2512466	hsa-miR-4430	CLIP-seq
MIRT2208579	hsa-miR-4451	CLIP-seq
MIRT2208580	hsa-miR-4650-3p	CLIP-seq
MIRT921260	hsa-miR-4714-3p	CLIP-seq
MIRT921263	hsa-miR-4726-3p	CLIP-seq
MIRT2512467	hsa-miR-4730	CLIP-seq
MIRT2208583	hsa-miR-4735-5p	CLIP-seq
MIRT2208585	hsa-miR-4775	CLIP-seq
MIRT1972974	hsa-miR-590-3p	CLIP-seq
MIRT2208569	hsa-miR-3149	CLIP-seq
MIRT2208571	hsa-miR-3529	CLIP-seq
MIRT2678975	hsa-miR-3619-3p	CLIP-seq
MIRT2208575	hsa-miR-379	CLIP-seq
MIRT2208579	hsa-miR-4451	CLIP-seq
MIRT2208580	hsa-miR-4650-3p	CLIP-seq
MIRT2208583	hsa-miR-4735-5p	CLIP-seq
MIRT2208585	hsa-miR-4775	CLIP-seq
MIRT1972974	hsa-miR-590-3p	CLIP-seq
MIRT2208592	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001972	Function	Retinoic acid binding	IBA
GO:0001972	Function	Retinoic acid binding	IDA	27059013
GO:0004497	Function	Monooxygenase activity	IEA
GO:0005502	Function	11-cis retinal binding	IDA	27059013
GO:0005503	Function	All-trans retinal binding	IDA	27059013
GO:0005506	Function	Iron ion binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0006066	Process	Alcohol metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016705	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA
GO:0020037	Function	Heme binding	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0042572	Process	Retinol metabolic process	IDA	27059013, 28701464
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042573	Process	Retinoic acid metabolic process	IDA	27059013
GO:0042574	Process	Retinal metabolic process	IDA	27059013
GO:0046872	Function	Metal ion binding	IEA
GO:0061896	Function	All-trans retinol 3,4-desaturase activity	IBA
GO:0061896	Function	All-trans retinol 3,4-desaturase activity	IDA	27059013, 28701464
GO:0061896	Function	All-trans retinol 3,4-desaturase activity	IEA
GO:0061897	Function	All-trans retinal 3,4-desaturase activity	IBA
GO:0061897	Function	All-trans retinal 3,4-desaturase activity	IDA	27059013
GO:0061898	Function	All-trans retinoic acid 3,4-desaturase activity	IBA
GO:0061898	Function	All-trans retinoic acid 3,4-desaturase activity	IDA	27059013
GO:0061899	Function	11-cis-retinal 3,4-desaturase activity	IDA	27059013
GO:1904768	Function	All-trans-retinol binding	IBA
GO:1904768	Function	All-trans-retinol binding	IDA	27059013

Other IDs

• MIM: 620605
• HGNC: 33480
• e!Ensembl: ENSG00000186684

Protein

• UniProt ID: Q4G0S4
• Protein name: Cytochrome P450 27C1 (EC 1.14.19.53) (All-trans retinol 3,4-desaturase)
• Protein function: [Isoform 2]: A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans re
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00067	p450	1 → 368	Cytochrome P450	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with highest levels in the liver, kidney and pancreas. {ECO:0000269|PubMed:16360114}.; TISSUE SPECIFICITY: [Isoform 2]: Expressed in the skin (at protein level). {ECO:0000269|PubMed:28701464}.
• Sequence:

  MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQPAGARLPAGARAEDKGAGRPGSPP
  GGGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQFVV
  SIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRIL
  KPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRL
  GCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFS
  QIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLS
  WTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGR
  VTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIP
  FGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVN
  RK

• Sequence length: 542

Pathways

KEGG:

Retinol metabolism

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Lung Neoplasms	Associate	35887201	★☆☆☆☆ Found in Text Mining only