Gene Gene information from NCBI Gene database.
Entrez ID 339500
Gene name Zinc finger protein 678
Gene symbol ZNF678
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1q42.13
miRNA miRNA information provided by mirtarbase database.
713
miRTarBase ID miRNA Experiments Reference
MIRT016109 hsa-miR-421 Sequencing 20371350
MIRT017986 hsa-miR-335-5p Microarray 18185580
MIRT563771 hsa-miR-548ac PAR-CLIP 20371350
MIRT563770 hsa-miR-548bb-3p PAR-CLIP 20371350
MIRT563769 hsa-miR-548d-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5SXM1
Protein name Zinc finger protein 678
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 125 147 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 153 175 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 181 203 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 209 231 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 237 262 Domain
PF00096 zf-C2H2 265 287 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 293 315 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 321 343 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 349 371 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 377 399 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 405 427 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 433 455 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 461 483 Zinc finger, C2H2 type Domain
Sequence
MGTISLCIGVCAFEGANTSTSFYKLVYTAILSYSIQDLLPEQDMKDLCQKVTLTRHRSWG
LDNLHLVKDWRTVNEGKGQKEYCNRLTQCSSTKSKIFQCIECGRNFSWRSILTEHKRIHT
GEKPYKCEECGKVFNRCSNLTKHKRIHTGEKPYKCDECGKVFNWWSQLTNHKKIHTGEKP
YKCDECDKVFNWWSQLTSHKKIHSGEKPYPCEECGKAFTQFSNLTQHKRIHTGEKPYKCK
ECCKAFNKFSNLTQHKRIHTGE
KPYKCEECGNVFNECSHLTRHRRIHTGEKPYKCEECGK
AFTQFASLTRHKRIH
TGEKPYQCEECGKTFNRCSHLSSHKRIHTGEKPYKCEECGRTFTQ
FSNLTQHKRIH
TGEKPYKCKECGKAFNKFSSLTQHRRIHTGVKPYKCEECGKVFKQCSHL
TSHKRIH
TGEKPYKCKECGKAFYQSSILSKHKRIHTEEKPYKCEECGKAFNQFSSLTRHK
RIH
TGEKRYKCKECGKGFYQSSIHSKYKRIYTGEEPDKCKKCGSL
Sequence length 525
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Pulmonary Arterial Hypertension Associate 38184627
★☆☆☆☆
Found in Text Mining only
Pulmonary Disease Chronic Obstructive Associate 37955025
★☆☆☆☆
Found in Text Mining only