Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	339345
Gene name	Nanos C2HC-type zinc finger 2
Gene symbol	NANOS2
Synonyms (NCBI Gene)	NOS2ZC2HC12B
Chromosome	19
Chromosome location	19q13.32

Show/Hide all (36)

miRTarBase ID	miRNA	Experiments
MIRT1173405	hsa-miR-2110	CLIP-seq
MIRT1173406	hsa-miR-3150a-3p	CLIP-seq
MIRT1173407	hsa-miR-4260	CLIP-seq
MIRT1173408	hsa-miR-4450	CLIP-seq
MIRT1173409	hsa-miR-4488	CLIP-seq
MIRT1173410	hsa-miR-4655-5p	CLIP-seq
MIRT1173411	hsa-miR-4697-5p	CLIP-seq
MIRT1173412	hsa-miR-4736	CLIP-seq
MIRT1173413	hsa-miR-486-3p	CLIP-seq
MIRT2050252	hsa-miR-342-5p	CLIP-seq
MIRT2050253	hsa-miR-4459	CLIP-seq
MIRT2050254	hsa-miR-4664-5p	CLIP-seq
MIRT1173405	hsa-miR-2110	CLIP-seq
MIRT1173406	hsa-miR-3150a-3p	CLIP-seq
MIRT1173407	hsa-miR-4260	CLIP-seq
MIRT1173408	hsa-miR-4450	CLIP-seq
MIRT1173409	hsa-miR-4488	CLIP-seq
MIRT1173410	hsa-miR-4655-5p	CLIP-seq
MIRT1173411	hsa-miR-4697-5p	CLIP-seq
MIRT1173412	hsa-miR-4736	CLIP-seq
MIRT1173413	hsa-miR-486-3p	CLIP-seq
MIRT1173405	hsa-miR-2110	CLIP-seq
MIRT1173406	hsa-miR-3150a-3p	CLIP-seq
MIRT1173407	hsa-miR-4260	CLIP-seq
MIRT1173408	hsa-miR-4450	CLIP-seq
MIRT1173409	hsa-miR-4488	CLIP-seq
MIRT1173411	hsa-miR-4697-5p	CLIP-seq
MIRT1173412	hsa-miR-4736	CLIP-seq
MIRT1173413	hsa-miR-486-3p	CLIP-seq
MIRT2685780	hsa-miR-1248	CLIP-seq
MIRT2685781	hsa-miR-4659a-3p	CLIP-seq
MIRT2685782	hsa-miR-4659b-3p	CLIP-seq
MIRT2685783	hsa-miR-4749-3p	CLIP-seq
MIRT2685784	hsa-miR-4753-3p	CLIP-seq
MIRT2685785	hsa-miR-4778-3p	CLIP-seq
MIRT2685786	hsa-miR-942	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IEA
GO:0000932	Component	P-body	ISS
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	IEA
GO:0005515	Function	Protein binding	IPI	24736845, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IDA	22899867
GO:0005737	Component	Cytoplasm	IDA	19168545
GO:0005737	Component	Cytoplasm	IEA
GO:0006402	Process	MRNA catabolic process	IEA
GO:0006402	Process	MRNA catabolic process	ISS
GO:0006417	Process	Regulation of translation	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0008047	Function	Enzyme activator activity	IDA	24736845
GO:0008047	Function	Enzyme activator activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0017148	Process	Negative regulation of translation	IBA
GO:0017148	Process	Negative regulation of translation	IDA	24736845
GO:0017148	Process	Negative regulation of translation	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030718	Process	Germ-line stem cell population maintenance	IEA
GO:0030718	Process	Germ-line stem cell population maintenance	ISS
GO:0045835	Process	Negative regulation of meiotic nuclear division	IEA
GO:0045835	Process	Negative regulation of meiotic nuclear division	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	19168545
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048477	Process	Oogenesis	IBA
GO:0061157	Process	MRNA destabilization	IDA	24736845
GO:0061157	Process	MRNA destabilization	IEA

MIM	HGNC	e!Ensembl
608228	23292	ENSG00000188425

P60321

Protein name

Nanos homolog 2 (NOS-2)

Protein function

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintain

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05741	zf-nanos	63 → 116	Nanos RNA binding domain	Family

Tissue specificity

TISSUE SPECIFICITY: Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level). {ECO:0000269|PubMed:1916

Sequence

MQLPPFDMWKDYFNLSQVVWALIASRGQRLETQEIEEPSPGPPLGQDQGLGAPGANGGLG
TLCNFCKHNGESRHVYSSHQLKTPDGVVVCPILRHYVCPVCGATGDQAHTLKYCPLNGGQ
QSLYRRSGRNSAGRRVKR

Sequence length

138

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFERTILITY, MALE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Azoospermia Nonobstructive	Associate	29790874	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	36012673	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	36012673, 37454491	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sertoli Cell Only Syndrome	Associate	37296437	★★★★★ ★☆☆☆☆ Found in Text Mining only

NANOS2 (nanos C2HC-type zinc finger 2)