Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	339105
Gene name Gene Name - the full gene name approved by the HGNC.	Serine protease 53
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRSS53
Synonyms (NCBI Gene) Gene synonyms aliases	POL3S, UNQ308
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p11.2

Show/Hide all(32)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016806	hsa-miR-335-5p	Microarray	18185580
MIRT1268580	hsa-miR-1205	CLIP-seq
MIRT1268581	hsa-miR-1260	CLIP-seq
MIRT1268582	hsa-miR-1260b	CLIP-seq
MIRT1268583	hsa-miR-1262	CLIP-seq
MIRT1268584	hsa-miR-188-3p	CLIP-seq
MIRT1268585	hsa-miR-1909	CLIP-seq
MIRT1268586	hsa-miR-3150a-3p	CLIP-seq
MIRT1268587	hsa-miR-3156-3p	CLIP-seq
MIRT1268588	hsa-miR-3175	CLIP-seq
MIRT1268589	hsa-miR-339-5p	CLIP-seq
MIRT1268590	hsa-miR-3667-3p	CLIP-seq
MIRT1268591	hsa-miR-4259	CLIP-seq
MIRT1268592	hsa-miR-4455	CLIP-seq
MIRT1268593	hsa-miR-4481	CLIP-seq
MIRT1268594	hsa-miR-4514	CLIP-seq
MIRT1268595	hsa-miR-4645-5p	CLIP-seq
MIRT1268596	hsa-miR-4648	CLIP-seq
MIRT1268597	hsa-miR-4654	CLIP-seq
MIRT1268598	hsa-miR-4673	CLIP-seq
MIRT1268599	hsa-miR-4692	CLIP-seq
MIRT1268600	hsa-miR-4701-3p	CLIP-seq
MIRT1268601	hsa-miR-4736	CLIP-seq
MIRT1268602	hsa-miR-4745-5p	CLIP-seq
MIRT1268603	hsa-miR-4769-5p	CLIP-seq
MIRT1268604	hsa-miR-491-5p	CLIP-seq
MIRT1268605	hsa-miR-571	CLIP-seq
MIRT1268606	hsa-miR-609	CLIP-seq
MIRT1268607	hsa-miR-657	CLIP-seq
MIRT1268608	hsa-miR-663b	CLIP-seq
MIRT1268609	hsa-miR-939	CLIP-seq
MIRT1268610	hsa-miR-940	CLIP-seq

Show/Hide all(4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0006508	Process	Proteolysis	IEA

MIM	HGNC	e!Ensembl
610561	34407	ENSG00000151006

Protein

UniProt ID

Q2L4Q9

Protein name

Serine protease 53 (EC 3.4.21.-) (Polyserine protease 3) (Polyserase-3)

Protein function

In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00089	Trypsin	39 → 268	Trypsin	Domain
PF00089	Trypsin	302 → 521	Trypsin	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines. {ECO:0000269|PubMed:16566820}.

Sequence

MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGA
PLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEP
GSCLANISQPTSC

Sequence length

553

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	22451204

PRSS53 (serine protease 53)