PRSS53 (serine protease 53)

Gene

• Entrez ID: 339105
• Gene name: Serine protease 53
• Gene symbol: PRSS53
• Synonyms (NCBI Gene): POL3S, UNQ308
• Chromosome: 16
• Chromosome location: 16p11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016806	hsa-miR-335-5p	Microarray	18185580
MIRT1268580	hsa-miR-1205	CLIP-seq
MIRT1268581	hsa-miR-1260	CLIP-seq
MIRT1268582	hsa-miR-1260b	CLIP-seq
MIRT1268583	hsa-miR-1262	CLIP-seq
MIRT1268584	hsa-miR-188-3p	CLIP-seq
MIRT1268585	hsa-miR-1909	CLIP-seq
MIRT1268586	hsa-miR-3150a-3p	CLIP-seq
MIRT1268587	hsa-miR-3156-3p	CLIP-seq
MIRT1268588	hsa-miR-3175	CLIP-seq
MIRT1268589	hsa-miR-339-5p	CLIP-seq
MIRT1268590	hsa-miR-3667-3p	CLIP-seq
MIRT1268591	hsa-miR-4259	CLIP-seq
MIRT1268592	hsa-miR-4455	CLIP-seq
MIRT1268593	hsa-miR-4481	CLIP-seq
MIRT1268594	hsa-miR-4514	CLIP-seq
MIRT1268595	hsa-miR-4645-5p	CLIP-seq
MIRT1268596	hsa-miR-4648	CLIP-seq
MIRT1268597	hsa-miR-4654	CLIP-seq
MIRT1268598	hsa-miR-4673	CLIP-seq
MIRT1268599	hsa-miR-4692	CLIP-seq
MIRT1268600	hsa-miR-4701-3p	CLIP-seq
MIRT1268601	hsa-miR-4736	CLIP-seq
MIRT1268602	hsa-miR-4745-5p	CLIP-seq
MIRT1268603	hsa-miR-4769-5p	CLIP-seq
MIRT1268604	hsa-miR-491-5p	CLIP-seq
MIRT1268605	hsa-miR-571	CLIP-seq
MIRT1268606	hsa-miR-609	CLIP-seq
MIRT1268607	hsa-miR-657	CLIP-seq
MIRT1268608	hsa-miR-663b	CLIP-seq
MIRT1268609	hsa-miR-939	CLIP-seq
MIRT1268610	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA

Other IDs

• MIM: 610561
• HGNC: 34407
• e!Ensembl: ENSG00000151006

Protein

• UniProt ID: Q2L4Q9
• Protein name: Serine protease 53 (EC 3.4.21.-) (Polyserine protease 3) (Polyserase-3)
• Protein function: In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00089	Trypsin	39 → 268	Trypsin	Domain
  PF00089	Trypsin	302 → 521	Trypsin	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines. {ECO:0000269|PubMed:16566820}.
• Sequence:

  MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
  ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
  NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
  LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
  GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
  TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
  EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
  RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGA
  PLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEP
  GSCLANISQPTSC

• Sequence length: 553

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