Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	338557
Gene name	Free fatty acid receptor 4
Gene symbol	FFAR4
Synonyms (NCBI Gene)	BMIQ10GPR120GPR129GT01O3FAR1OB10QPGR4
Chromosome	10
Chromosome location	10q23.33
Summary	This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insuli

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SNP ID	Visualize variation	Clinical significance	Consequence
rs116454156	G>A	Risk-factor	Genic downstream transcript variant, missense variant, coding sequence variant

128

Show/Hide all (128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT679180	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT679179	hsa-miR-764	HITS-CLIP	23824327
MIRT679178	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT679177	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679176	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679175	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679174	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT645789	hsa-miR-142-5p	HITS-CLIP	23824327
MIRT645788	hsa-miR-5590-3p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT645787	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT645786	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT645785	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT645784	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT645783	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT645782	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT645781	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT645780	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT645779	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327
MIRT679180	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT679179	hsa-miR-764	HITS-CLIP	23824327
MIRT679178	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT679177	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679176	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679175	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679174	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT645789	hsa-miR-142-5p	HITS-CLIP	23824327
MIRT645788	hsa-miR-5590-3p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT645787	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT645786	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT645785	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT645784	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT645783	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT645782	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT645781	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT645780	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT645779	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001818	Process	Negative regulation of cytokine production	IEA
GO:0001818	Process	Negative regulation of cytokine production	ISS
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005504	Function	Fatty acid binding	IBA
GO:0005504	Function	Fatty acid binding	IEA
GO:0005504	Function	Fatty acid binding	ISS
GO:0005515	Function	Protein binding	IPI	22282525
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	22282525
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22282525
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IDA	31761534
GO:0005929	Component	Cilium	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	27852822
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	22282525, 24742677, 27852822
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0008527	Function	Taste receptor activity	IBA
GO:0008527	Function	Taste receptor activity	IEA
GO:0010008	Component	Endosome membrane	IDA	22282525
GO:0010008	Component	Endosome membrane	IEA
GO:0010827	Process	Regulation of D-glucose transmembrane transport	IEA
GO:0010827	Process	Regulation of D-glucose transmembrane transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0030139	Component	Endocytic vesicle	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IMP	23809162
GO:0036064	Component	Ciliary basal body	IDA
GO:0036321	Process	Ghrelin secretion	IEA
GO:0036321	Process	Ghrelin secretion	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	ISS
GO:0045444	Process	Fat cell differentiation	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	ISS
GO:0046879	Process	Hormone secretion	IBA
GO:0046879	Process	Hormone secretion	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0050728	Process	Negative regulation of inflammatory response	ISS
GO:0050872	Process	White fat cell differentiation	IDA	31761534
GO:0050872	Process	White fat cell differentiation	IEA
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0050873	Process	Brown fat cell differentiation	ISS
GO:0050912	Process	Detection of chemical stimulus involved in sensory perception of taste	IEA
GO:0060170	Component	Ciliary membrane	IEA
GO:0070094	Process	Positive regulation of glucagon secretion	IEA
GO:0070094	Process	Positive regulation of glucagon secretion	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0090275	Process	Negative regulation of somatostatin secretion	IEA
GO:0090275	Process	Negative regulation of somatostatin secretion	ISS
GO:0090336	Process	Positive regulation of brown fat cell differentiation	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	27853148
GO:1990763	Function	Arrestin family protein binding	IDA	22282525

MIM	HGNC	e!Ensembl
609044	19061	ENSG00000186188

Q5NUL3

Protein name

Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)

Protein function

[Isoform 2]: G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways (PubMed:22282525, PubMed:22343897, PubMed:24742677

PDB

8G59 , 8H4I , 8H4K , 8H4L , 8ID3 , 8ID4 , 8ID6 , 8ID8 , 8ID9 , 8IYS , 8T3O , 8T3Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	57 → 337	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: [Isoform 2]: The predominant isoform in human tissues. Expressed in adipose tissue, pancreatic islets, lung and brain. Expressed in alpha cells of pancreatic islets (PubMed:24742677). Expressed in primary cilia of perivascular preadipo

Sequence

MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC
ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL
SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV
PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKR
LTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWP
SLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIIS
G

Sequence length

361

Interactions

View interactions

	Reactome
			Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 10	Uncertain significance	rs116454156	RCV000023753

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Inhibit	38243188
Breast Neoplasms	Associate	30795784
Cholangiocarcinoma	Associate	30248044
Diabetes Gestational	Stimulate	37842292
Endocrine System Diseases	Associate	30795784
Hypertriglyceridemia	Associate	19287041
Inflammation	Associate	23594480, 24505350, 24790272, 24817122
Insulin Resistance	Associate	24790272, 30190473
Lung Neoplasms	Associate	25644374
Lymphatic Metastasis	Associate	30248044
Lymphatic Metastasis	Stimulate	31539131
Metabolic Diseases	Associate	24860101
Neoplasms	Associate	30248044, 30764601, 30795784
Neoplasms	Stimulate	33299884
Neoplasms Adipose Tissue	Associate	30795784
Obesity	Stimulate	22083550
Obesity	Associate	23594480, 24844436, 25258406, 33299884
Obesity	Inhibit	24790272
Obesity Maternal	Associate	24844436
Prostatic Neoplasms	Associate	27474750
Sleep Apnea Obstructive	Inhibit	24790272
Stomach Diseases	Associate	22083550
Tarlov Cysts	Associate	30248044
Vitamin A Deficiency	Associate	34063790

FFAR4 (free fatty acid receptor 4)