Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	338557
Gene name Gene Name - the full gene name approved by the HGNC.	Free fatty acid receptor 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FFAR4
Synonyms (NCBI Gene) Gene synonyms aliases	BMIQ10, GPR120, GPR129, GT01, O3FAR1, OB10Q, PGR4
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q23.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insuli

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SNP ID	Visualize variation	Clinical significance	Consequence
rs116454156	G>A	Risk-factor	Genic downstream transcript variant, missense variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT679180	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT679179	hsa-miR-764	HITS-CLIP	23824327
MIRT679178	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT679177	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679176	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679175	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679174	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT645789	hsa-miR-142-5p	HITS-CLIP	23824327
MIRT645788	hsa-miR-5590-3p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT645787	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT645786	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT645785	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT645784	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT645783	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT645782	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT645781	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT645780	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT645779	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327
MIRT679180	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT679179	hsa-miR-764	HITS-CLIP	23824327
MIRT679178	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT679177	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679176	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679175	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679174	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT645789	hsa-miR-142-5p	HITS-CLIP	23824327
MIRT645788	hsa-miR-5590-3p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT645787	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT645786	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT645785	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT645784	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT645783	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT645782	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT645781	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT645780	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT645779	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT639387	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT639386	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT639385	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT639384	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT639383	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT639381	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT639382	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639380	hsa-miR-3926	HITS-CLIP	23824327
MIRT639379	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT639378	hsa-miR-548s	HITS-CLIP	23824327
MIRT631511	hsa-miR-548av-3p	HITS-CLIP	23824327
MIRT631510	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT631509	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT631508	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT631506	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT631507	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631505	hsa-miR-640	HITS-CLIP	23824327

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001818	Process	Negative regulation of cytokine production	IEA
GO:0001818	Process	Negative regulation of cytokine production	ISS
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005504	Function	Fatty acid binding	IBA
GO:0005504	Function	Fatty acid binding	IEA
GO:0005504	Function	Fatty acid binding	ISS
GO:0005515	Function	Protein binding	IPI	22282525
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	22282525
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22282525
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IDA	31761534
GO:0005929	Component	Cilium	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	27852822
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	22282525, 24742677, 27852822
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0008527	Function	Taste receptor activity	IBA
GO:0008527	Function	Taste receptor activity	IEA
GO:0010008	Component	Endosome membrane	IDA	22282525
GO:0010008	Component	Endosome membrane	IEA
GO:0010827	Process	Regulation of D-glucose transmembrane transport	IEA
GO:0010827	Process	Regulation of D-glucose transmembrane transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0030139	Component	Endocytic vesicle	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IMP	23809162
GO:0036064	Component	Ciliary basal body	IDA
GO:0036321	Process	Ghrelin secretion	IEA
GO:0036321	Process	Ghrelin secretion	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	ISS
GO:0045444	Process	Fat cell differentiation	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	ISS
GO:0046879	Process	Hormone secretion	IBA
GO:0046879	Process	Hormone secretion	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0050728	Process	Negative regulation of inflammatory response	ISS
GO:0050872	Process	White fat cell differentiation	IDA	31761534
GO:0050872	Process	White fat cell differentiation	IEA
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0050873	Process	Brown fat cell differentiation	ISS
GO:0050912	Process	Detection of chemical stimulus involved in sensory perception of taste	IEA
GO:0060170	Component	Ciliary membrane	IEA
GO:0070094	Process	Positive regulation of glucagon secretion	IEA
GO:0070094	Process	Positive regulation of glucagon secretion	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0090275	Process	Negative regulation of somatostatin secretion	IEA
GO:0090275	Process	Negative regulation of somatostatin secretion	ISS
GO:0090336	Process	Positive regulation of brown fat cell differentiation	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	27853148
GO:1990763	Function	Arrestin family protein binding	IDA	22282525

MIM	HGNC	e!Ensembl
609044	19061	ENSG00000186188

Protein

UniProt ID

Q5NUL3

Protein name

Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)

Protein function

[Isoform 2]: G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways (PubMed:22282525, PubMed:22343897, PubMed:24742677

PDB

8G59 , 8H4I , 8H4K , 8H4L , 8ID3 , 8ID4 , 8ID6 , 8ID8 , 8ID9 , 8IYS , 8T3O , 8T3Q

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	57 → 337	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: [Isoform 2]: The predominant isoform in human tissues. Expressed in adipose tissue, pancreatic islets, lung and brain. Expressed in alpha cells of pancreatic islets (PubMed:24742677). Expressed in primary cilia of perivascular preadipo

Sequence

MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVC
ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL
SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVV
PQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKR
LTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWP
SLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIIS
G

Sequence length

361

Interactions

View interactions

	Reactome
			Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events

FFAR4 (free fatty acid receptor 4)