Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	338442
Gene name Gene Name - the full gene name approved by the HGNC.	Hydroxycarboxylic acid receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HCAR2
Synonyms (NCBI Gene) Gene synonyms aliases	GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.31

Show/Hide all(28)

miRTarBase ID	miRNA	Experiments	Reference
MIRT657487	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT657486	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT657485	hsa-miR-409-3p	HITS-CLIP	23824327
MIRT657484	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT657483	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT657482	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT657481	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT657479	hsa-miR-623	HITS-CLIP	23824327
MIRT657480	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT657478	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT657477	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT657487	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT657486	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT657485	hsa-miR-409-3p	HITS-CLIP	23824327
MIRT657484	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT657483	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT657482	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT657481	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT657479	hsa-miR-623	HITS-CLIP	23824327
MIRT657480	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT657478	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT657477	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1041686	hsa-miR-204	CLIP-seq
MIRT1041687	hsa-miR-211	CLIP-seq
MIRT1041688	hsa-miR-3153	CLIP-seq
MIRT1041689	hsa-miR-4257	CLIP-seq
MIRT1041690	hsa-miR-4261	CLIP-seq
MIRT1041691	hsa-miR-4668-5p	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001781	Process	Neutrophil apoptotic process	IDA	17932499
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17932499
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0033031	Process	Positive regulation of neutrophil apoptotic process	IDA	17932499
GO:0050995	Process	Negative regulation of lipid catabolic process	ISS
GO:0070165	Process	Positive regulation of adiponectin secretion	ISS
GO:0070553	Function	Nicotinic acid receptor activity	IBA
GO:0070553	Function	Nicotinic acid receptor activity	ISS

MIM	HGNC	e!Ensembl
609163	24827	ENSG00000182782

Protein

UniProt ID

Q8TDS4

Protein name

Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)

Protein function

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This

PDB

7XK2 , 7ZL9 , 7ZLY , 8H2G , 8I7V , 8I7W , 8IHB , 8IHF , 8IHH , 8IHI , 8IJ3 , 8IJA , 8IJB , 8IJD , 8IY9 , 8IYH , 8IYW , 8J6I , 8J6J , 8J6L , 8J6P , 8J6Q , 8J6R , 8JER , 8JHN , 8JHY , 8JII , 8JIL , 8JIM , 8JZ7 , 8K5B , 8K5C , 8K5D , 8UTD , 9IQT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	44 → 294	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:17932499}.

Sequence

MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP

Sequence length

363

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway		Hydroxycarboxylic acid-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Obsessive-Compulsive Disorder	Obsessive-compulsive disorder	N/A	N/A	GWAS

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adrenocortical Carcinoma	Associate	34220331
Asthma	Associate	34727921
Atherosclerosis	Associate	30270326
Bipolar Disorder	Stimulate	19502010
Breast Neoplasms	Associate	34852802
Carcinoma Hepatocellular	Associate	29138264
Carcinoma Renal Cell	Inhibit	23658787
Colorectal Neoplasms	Associate	28333199
Cytokine Release Syndrome	Associate	30270326
Death	Associate	34220331
Graft vs Host Disease	Associate	34777363
Hepatitis B	Associate	29138264
Inflammation	Associate	22267479, 28333199, 30270326
Inflammation	Inhibit	25329911
Inflammatory Bowel Diseases	Associate	39233260
Mental Disorders	Associate	37984442
Neoplasms Squamous Cell	Associate	21655214
Obesity	Associate	30270326
Parkinson Disease	Stimulate	25329911
Schizophrenia	Stimulate	19502010
Schizophrenia	Associate	37984442
Skin Neoplasms	Associate	21655214
Uterine Cervical Neoplasms	Associate	37370057
Zika Virus Infection	Associate	32039055

HCAR2 (hydroxycarboxylic acid receptor 2)