HCAR2 (hydroxycarboxylic acid receptor 2)

Gene

• Entrez ID: 338442
• Gene name: Hydroxycarboxylic acid receptor 2
• Gene symbol: HCAR2
• Synonyms (NCBI Gene): GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g
• Chromosome: 12
• Chromosome location: 12q24.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT657487	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT657486	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT657485	hsa-miR-409-3p	HITS-CLIP	23824327
MIRT657484	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT657483	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT657482	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT657481	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT657479	hsa-miR-623	HITS-CLIP	23824327
MIRT657480	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT657478	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT657477	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT657487	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT657486	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT657485	hsa-miR-409-3p	HITS-CLIP	23824327
MIRT657484	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT657483	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT657482	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT657481	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT657479	hsa-miR-623	HITS-CLIP	23824327
MIRT657480	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT657478	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT657477	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT1041686	hsa-miR-204	CLIP-seq
MIRT1041687	hsa-miR-211	CLIP-seq
MIRT1041688	hsa-miR-3153	CLIP-seq
MIRT1041689	hsa-miR-4257	CLIP-seq
MIRT1041690	hsa-miR-4261	CLIP-seq
MIRT1041691	hsa-miR-4668-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001781	Process	Neutrophil apoptotic process	IDA	17932499
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17932499
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0033031	Process	Positive regulation of neutrophil apoptotic process	IDA	17932499
GO:0050995	Process	Negative regulation of lipid catabolic process	ISS
GO:0070165	Process	Positive regulation of adiponectin secretion	ISS
GO:0070553	Function	Nicotinic acid receptor activity	IBA
GO:0070553	Function	Nicotinic acid receptor activity	ISS

Other IDs

• MIM: 609163
• HGNC: 24827
• e!Ensembl: ENSG00000182782

Protein

• UniProt ID: Q8TDS4
• Protein name: Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)
• Protein function: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This
• PDB: 7XK2, 7ZL9, 7ZLY, 8H2G, 8I7V, 8I7W, 8IHB, 8IHF, 8IHH, 8IHI, 8IJ3, 8IJA, 8IJB, 8IJD, 8IY9, 8IYH, 8IYW, 8J6I, 8J6J, 8J6L, 8J6P, 8J6Q, 8J6R, 8JER, 8JHN, 8JHY, 8JII, 8JIL, 8JIM, 8JZ7, 8K5B, 8K5C, 8K5D, 8UTD, 9IQT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	44 → 294	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:17932499}.
• Sequence:

  MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
  SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
  VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
  SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
  VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
  FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
  TSP

• Sequence length: 363

Pathways

KEGG:

cAMP signaling pathway

Reactome:

Hydroxycarboxylic acid-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events