Gene Gene information from NCBI Gene database.
Entrez ID 3383
Gene name Intercellular adhesion molecule 1
Gene symbol ICAM1
Synonyms (NCBI Gene)
BB2CD54P3.58
Chromosome 19
Chromosome location 19p13.2
Summary This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by Ref
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs5491 A>G,T Risk-factor Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
581
miRTarBase ID miRNA Experiments Reference
MIRT004430 hsa-miR-221-3p Luciferase reporter assayWestern blot 20110463
MIRT004430 hsa-miR-221-3p Luciferase reporter assayWestern blot 20110463
MIRT004595 hsa-miR-222-3p Review 20144731
MIRT004596 hsa-miR-339-5p Review 20144731
MIRT004020 hsa-miR-17-3p ImmunocytochemistryNorthern blotqRT-PCRWestern blot 19949084
Transcription factors Transcription factors information provided by TRRUST V2 database.
23
Transcription factor Regulation Reference
CEBPA Unknown 9916895
ERG Repression 22235125
ETS2 Activation 9572487
ETV5 Activation 9572487
HDAC1 Activation 12490396
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IEA
GO:0001772 Component Immunological synapse IEA
GO:0001910 Process Regulation of leukocyte mediated cytotoxicity TAS 16038038
GO:0002252 Process Immune effector process IEA
GO:0002291 Process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147840 5344 ENSG00000090339
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05362
Protein name Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Protein function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activati
PDB 1D3E , 1D3I , 1D3L , 1IAM , 1IC1 , 1MQ8 , 1P53 , 1Z7Z , 2OZ4 , 3TCX , 5MZA , 6EIT , 6S8U , 7BG7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03921 ICAM_N 24 115 Intercellular adhesion molecule (ICAM), N-terminal domain Domain
Sequence
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPER
VELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Sequence length 532
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  NF-kappa B signaling pathway
Cell adhesion molecules
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Leukocyte transendothelial migration
AGE-RAGE signaling pathway in diabetic complications
African trypanosomiasis
Malaria
Staphylococcus aureus infection
Influenza A
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Rheumatoid arthritis
Viral myocarditis
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
18
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
ICAM1-related disorder Likely benign; Benign; risk factor rs376045646, rs5491, rs1799969, rs35956512, rs548184831, rs5490, rs5498, rs5030381, rs146134321, rs150121537 RCV003966381
RCV003914847
RCV003977378
RCV003951990
RCV003944367
RCV003979302
RCV003982106
RCV003968114
RCV003930661
RCV003957930
Malaria, cerebral, susceptibility to Benign; risk factor rs5491 RCV000015768
Malaria, susceptibility to Uncertain significance; Conflicting classifications of pathogenicity rs1225105373, rs753646159, rs747111380, rs5030400 RCV002208748
RCV002204529
RCV003224689
RCV001027828
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
ABCD syndrome Associate 39182041
Abnormalities Drug Induced Associate 10540181
Abortion Habitual Associate 27929073
Achondroplasia Stimulate 12823344
Acidosis Stimulate 22110680
Acne Vulgaris Associate 31281837
Acquired Immunodeficiency Syndrome Stimulate 7909296
Acrocephalosyndactylia Associate 24083591
Actinic Prurigo Associate 15191561
Acute Coronary Syndrome Associate 24452942