ICA1 (islet cell autoantigen 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3382
Gene name Gene Name - the full gene name approved by the HGNC.
Islet cell autoantigen 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ICA1
Synonyms (NCBI Gene) Gene synonyms aliases
ICA69, ICAp69
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p21.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mel
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT1058364 hsa-miR-4428 CLIP-seq
MIRT1058365 hsa-miR-183 CLIP-seq
MIRT1058366 hsa-miR-3662 CLIP-seq
MIRT1058367 hsa-miR-4477a CLIP-seq
MIRT1058368 hsa-miR-944 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(14)
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 12682071
GO:0005515 Function Protein binding IPI 25416956, 29892012
GO:0005737 Component Cytoplasm TAS 8326004
GO:0005794 Component Golgi apparatus IBA 21873635
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147625 5343 ENSG00000003147
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q05084
Protein name Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)
Protein function May play a role in neurotransmitter secretion.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06456 Arfaptin 22 → 249 Arfaptin-like domain Domain
PF04629 ICA69 261 → 448 Islet cell autoantigen ICA69, C-terminal domain Domain
PF04629 ICA69 442 → 483 Islet cell autoantigen ICA69, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.
Sequence
Sequence length 483
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Type I diabetes mellitus  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Show/Hide Text Mining Associations (12)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 10433084
Autistic Disorder Associate 22016809
Autoimmune Diseases Associate 10433084
Cataract Age Related Nuclear Associate 33213085
Diabetes Mellitus Type 1 Associate 10433084, 12409289, 35773317
Diabetes Mellitus Type 1 Stimulate 24517144
Glaucoma Associate 23836780
Glaucoma Open Angle Associate 23836780
Graves Disease Associate 24517144
Multiple Sclerosis Associate 24517144