IAPP (islet amyloid polypeptide)

Gene

• Entrez ID: 3375
• Gene name: Islet amyloid polypeptide
• Gene symbol: IAPP
• Synonyms (NCBI Gene): DAP, IAP
• Chromosome: 12
• Chromosome location: 12p12.1
• Summary: This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018914	hsa-miR-335-5p	Microarray	18185580
MIRT030101	hsa-miR-26b-5p	Microarray	19088304
MIRT440479	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT440477	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT440476	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440475	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT440479	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT440477	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT440476	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440475	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT1057988	hsa-miR-106a	CLIP-seq
MIRT1057989	hsa-miR-106b	CLIP-seq
MIRT1057990	hsa-miR-1200	CLIP-seq
MIRT1057991	hsa-miR-1234	CLIP-seq
MIRT1057992	hsa-miR-124	CLIP-seq
MIRT1057993	hsa-miR-1281	CLIP-seq
MIRT1057994	hsa-miR-1343	CLIP-seq
MIRT1057995	hsa-miR-150	CLIP-seq
MIRT1057996	hsa-miR-17	CLIP-seq
MIRT1057997	hsa-miR-197	CLIP-seq
MIRT1057998	hsa-miR-1976	CLIP-seq
MIRT1057999	hsa-miR-20a	CLIP-seq
MIRT1058000	hsa-miR-20b	CLIP-seq
MIRT1058001	hsa-miR-302a	CLIP-seq
MIRT1058002	hsa-miR-302b	CLIP-seq
MIRT1058003	hsa-miR-302c	CLIP-seq
MIRT1058004	hsa-miR-302d	CLIP-seq
MIRT1058005	hsa-miR-302e	CLIP-seq
MIRT1058006	hsa-miR-31	CLIP-seq
MIRT1058007	hsa-miR-3149	CLIP-seq
MIRT1058008	hsa-miR-3155	CLIP-seq
MIRT1058009	hsa-miR-3155b	CLIP-seq
MIRT1058010	hsa-miR-3663-5p	CLIP-seq
MIRT1058011	hsa-miR-3714	CLIP-seq
MIRT1058012	hsa-miR-372	CLIP-seq
MIRT1058013	hsa-miR-373	CLIP-seq
MIRT1058014	hsa-miR-3910	CLIP-seq
MIRT1058015	hsa-miR-411	CLIP-seq
MIRT1058016	hsa-miR-4279	CLIP-seq
MIRT1058017	hsa-miR-4324	CLIP-seq
MIRT1058018	hsa-miR-4438	CLIP-seq
MIRT1058019	hsa-miR-4503	CLIP-seq
MIRT1058020	hsa-miR-4707-5p	CLIP-seq
MIRT1058021	hsa-miR-4716-5p	CLIP-seq
MIRT1058022	hsa-miR-4722-3p	CLIP-seq
MIRT1058023	hsa-miR-4731-5p	CLIP-seq
MIRT1058024	hsa-miR-4735-5p	CLIP-seq
MIRT1058025	hsa-miR-4742-5p	CLIP-seq
MIRT1058026	hsa-miR-4763-5p	CLIP-seq
MIRT1058027	hsa-miR-4775	CLIP-seq
MIRT1058028	hsa-miR-4781-3p	CLIP-seq
MIRT1058029	hsa-miR-484	CLIP-seq
MIRT1058030	hsa-miR-506	CLIP-seq
MIRT1058031	hsa-miR-5095	CLIP-seq
MIRT1058032	hsa-miR-5096	CLIP-seq
MIRT1058033	hsa-miR-512-3p	CLIP-seq
MIRT1058034	hsa-miR-519d	CLIP-seq
MIRT1058035	hsa-miR-520a-3p	CLIP-seq
MIRT1058036	hsa-miR-520b	CLIP-seq
MIRT1058037	hsa-miR-520c-3p	CLIP-seq
MIRT1058038	hsa-miR-520d-3p	CLIP-seq
MIRT1058039	hsa-miR-520e	CLIP-seq
MIRT1058040	hsa-miR-520g	CLIP-seq
MIRT1058041	hsa-miR-520h	CLIP-seq
MIRT1058042	hsa-miR-544b	CLIP-seq
MIRT1058043	hsa-miR-590-3p	CLIP-seq
MIRT1058044	hsa-miR-629	CLIP-seq
MIRT1058045	hsa-miR-93	CLIP-seq
MIRT1057988	hsa-miR-106a	CLIP-seq
MIRT1057989	hsa-miR-106b	CLIP-seq
MIRT1057991	hsa-miR-1234	CLIP-seq
MIRT1057995	hsa-miR-150	CLIP-seq
MIRT1057996	hsa-miR-17	CLIP-seq
MIRT1057997	hsa-miR-197	CLIP-seq
MIRT1057999	hsa-miR-20a	CLIP-seq
MIRT1058000	hsa-miR-20b	CLIP-seq
MIRT1058001	hsa-miR-302a	CLIP-seq
MIRT1058002	hsa-miR-302b	CLIP-seq
MIRT1058003	hsa-miR-302c	CLIP-seq
MIRT1058004	hsa-miR-302d	CLIP-seq
MIRT1058005	hsa-miR-302e	CLIP-seq
MIRT1058007	hsa-miR-3149	CLIP-seq
MIRT1058008	hsa-miR-3155	CLIP-seq
MIRT1058009	hsa-miR-3155b	CLIP-seq
MIRT1058010	hsa-miR-3663-5p	CLIP-seq
MIRT1058012	hsa-miR-372	CLIP-seq
MIRT1058013	hsa-miR-373	CLIP-seq
MIRT1058015	hsa-miR-411	CLIP-seq
MIRT1058018	hsa-miR-4438	CLIP-seq
MIRT1058020	hsa-miR-4707-5p	CLIP-seq
MIRT1058021	hsa-miR-4716-5p	CLIP-seq
MIRT1058023	hsa-miR-4731-5p	CLIP-seq
MIRT1058026	hsa-miR-4763-5p	CLIP-seq
MIRT1058028	hsa-miR-4781-3p	CLIP-seq
MIRT1058029	hsa-miR-484	CLIP-seq
MIRT2013336	hsa-miR-495	CLIP-seq
MIRT1058031	hsa-miR-5095	CLIP-seq
MIRT1058032	hsa-miR-5096	CLIP-seq
MIRT1058033	hsa-miR-512-3p	CLIP-seq
MIRT1058034	hsa-miR-519d	CLIP-seq
MIRT1058035	hsa-miR-520a-3p	CLIP-seq
MIRT1058036	hsa-miR-520b	CLIP-seq
MIRT1058037	hsa-miR-520c-3p	CLIP-seq
MIRT1058038	hsa-miR-520d-3p	CLIP-seq
MIRT1058039	hsa-miR-520e	CLIP-seq
MIRT1058040	hsa-miR-520g	CLIP-seq
MIRT1058041	hsa-miR-520h	CLIP-seq
MIRT1058045	hsa-miR-93	CLIP-seq
MIRT1057990	hsa-miR-1200	CLIP-seq
MIRT2245556	hsa-miR-1283	CLIP-seq
MIRT1057997	hsa-miR-197	CLIP-seq
MIRT1057998	hsa-miR-1976	CLIP-seq
MIRT2245557	hsa-miR-3115	CLIP-seq
MIRT1058008	hsa-miR-3155	CLIP-seq
MIRT1058009	hsa-miR-3155b	CLIP-seq
MIRT1058010	hsa-miR-3663-5p	CLIP-seq
MIRT1058016	hsa-miR-4279	CLIP-seq
MIRT1058017	hsa-miR-4324	CLIP-seq
MIRT1058018	hsa-miR-4438	CLIP-seq
MIRT1058021	hsa-miR-4716-5p	CLIP-seq
MIRT1058022	hsa-miR-4722-3p	CLIP-seq
MIRT1058026	hsa-miR-4763-5p	CLIP-seq
MIRT1058028	hsa-miR-4781-3p	CLIP-seq
MIRT2245558	hsa-miR-4795-3p	CLIP-seq
MIRT1058029	hsa-miR-484	CLIP-seq
MIRT1058031	hsa-miR-5095	CLIP-seq
MIRT1058032	hsa-miR-5096	CLIP-seq
MIRT1058042	hsa-miR-544b	CLIP-seq
MIRT1058019	hsa-miR-4503	CLIP-seq
MIRT2548808	hsa-miR-122	CLIP-seq
MIRT1057993	hsa-miR-1281	CLIP-seq
MIRT2548809	hsa-miR-1307	CLIP-seq
MIRT1057994	hsa-miR-1343	CLIP-seq
MIRT1057998	hsa-miR-1976	CLIP-seq
MIRT2548810	hsa-miR-3135b	CLIP-seq
MIRT2548811	hsa-miR-3652	CLIP-seq
MIRT1058016	hsa-miR-4279	CLIP-seq
MIRT2548812	hsa-miR-4284	CLIP-seq
MIRT2548813	hsa-miR-4430	CLIP-seq
MIRT1058019	hsa-miR-4503	CLIP-seq
MIRT2548814	hsa-miR-4638-5p	CLIP-seq
MIRT2548815	hsa-miR-4715-3p	CLIP-seq
MIRT1058022	hsa-miR-4722-3p	CLIP-seq
MIRT2548816	hsa-miR-4772-3p	CLIP-seq
MIRT1058044	hsa-miR-629	CLIP-seq
MIRT2548808	hsa-miR-122	CLIP-seq
MIRT1057993	hsa-miR-1281	CLIP-seq
MIRT2548809	hsa-miR-1307	CLIP-seq
MIRT1057994	hsa-miR-1343	CLIP-seq
MIRT1057998	hsa-miR-1976	CLIP-seq
MIRT2548810	hsa-miR-3135b	CLIP-seq
MIRT2548811	hsa-miR-3652	CLIP-seq
MIRT1058016	hsa-miR-4279	CLIP-seq
MIRT2548812	hsa-miR-4284	CLIP-seq
MIRT2548813	hsa-miR-4430	CLIP-seq
MIRT1058019	hsa-miR-4503	CLIP-seq
MIRT2548814	hsa-miR-4638-5p	CLIP-seq
MIRT2548815	hsa-miR-4715-3p	CLIP-seq
MIRT1058022	hsa-miR-4722-3p	CLIP-seq
MIRT2548816	hsa-miR-4772-3p	CLIP-seq
MIRT1058044	hsa-miR-629	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
GATA4	Activation	17290010

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	TAS	22500019
GO:0005102	Function	Signaling receptor binding	TAS	2608057, 10342886
GO:0005179	Function	Hormone activity	IEA
GO:0005515	Function	Protein binding	IPI	17051221, 26840340
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006915	Process	Apoptotic process	TAS	8152488
GO:0007165	Process	Signal transduction	TAS	10342886
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	NAS	22500019
GO:0007267	Process	Cell-cell signaling	TAS	2608057
GO:0010739	Process	Positive regulation of protein kinase A signaling	NAS	22500019
GO:0010823	Process	Negative regulation of mitochondrion organization	TAS	22500019
GO:0019233	Process	Sensory perception of pain	IEA
GO:0031333	Process	Negative regulation of protein-containing complex assembly	TAS	22500019
GO:0042755	Process	Eating behavior	IEA
GO:0042802	Function	Identical protein binding	IPI	17640888, 18408164, 21130765, 24042052, 24561193, 26840340
GO:0043025	Component	Neuronal cell body	IEA
GO:0043065	Process	Positive regulation of apoptotic process	TAS	22500019
GO:0043410	Process	Positive regulation of MAPK cascade	NAS	22500019
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045596	Process	Negative regulation of cell differentiation	IEA
GO:0045779	Process	Negative regulation of bone resorption	IEA
GO:0051897	Process	Positive regulation of protein kinase B signaling	NAS	22500019
GO:0097647	Process	Amylin receptor signaling pathway	ISS
GO:1905907	Process	Negative regulation of amyloid fibril formation	TAS	22500019

Other IDs

• MIM: 147940
• HGNC: 5329
• e!Ensembl: ENSG00000121351

Protein

• UniProt ID: P10997
• Protein name: Islet amyloid polypeptide (IAPP) (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide)
• Protein function: Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affe
• PDB: 1KUW, 2G48, 2KB8, 2L86, 3DG1, 3FPO, 3FR1, 3FTH, 3FTK, 3FTL, 3FTR, 3G7V, 3G7W, 3HGZ, 5K5G, 5KNZ, 5KO0, 5MGQ, 6UCJ, 6UCK, 6VW2, 6Y1A, 6ZRF, 6ZRQ, 6ZRR, 7BG0, 7M61, 7M62, 7M64, 7M65, 7YKW, 7YL0, 7YL3, 7YL7, 8AWT, 8AZ0, 8AZ1, 8AZ2, 8AZ3, 8AZ4, 8AZ5, 8AZ6, 8AZ7, 8F0J, 8F0K, 8F2A, 8F2B, 8R4I, 8YG2, 9GZ6, 9GZP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00214	Calc_CGRP_IAPP	25 → 75	Calcitonin / CGRP / IAPP family	Family

• Sequence:

  MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAIL
  SSTNVGSNTYGKRNAVEVLKREPLNYLPL

• Sequence length: 89

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Hormone signaling
Maturity onset diabetes of the young

Reactome:

G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Amyloid fiber formation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	23793354, 16123366

Unknown
Disease term	Disease name	Evidence	References	Source
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
AA amyloidosis	Associate	11445568, 11790844, 15292167, 15878744, 16467158, 18825272, 22206987, 22734583, 23133593, 23256729, 24218609, 24654599, 24703313, 25531836, 25903685, 2639135, 26453205, 2690069, 27607147, 28684415, 29697253, 31922743, 31947546, 32385803, 32929282, 35210421, 38134875
AA amyloidosis	Stimulate	26453219, 9560308
Acute Disease	Associate	32385803
Adenoma Islet Cell	Associate	15878744, 18694973, 24703313, 2639135, 31705766, 31768548, 34044067, 38367541
Alzheimer Disease	Associate	14752113, 22500019, 24898659, 28684415, 31947546, 36835187
Amyloidosis	Associate	15878744, 17563070, 25531836
Bone Diseases	Associate	26895962, 26911465
Carcinoid Tumor	Associate	8317551
Cognition Disorders	Inhibit	24898659
Cognition Disorders	Associate	36835187
COVID 19	Associate	37246981
Dementia	Associate	27354094
Dementia Vascular	Associate	31947546
Diabetes Mellitus	Associate	11395927, 15878744, 16467158, 20421596, 25903685, 26895962, 26911465, 28614667, 31922743, 32929282, 36549505
Diabetes Mellitus Type 1	Associate	33832546
Diabetes Mellitus Type 2	Associate	10931181, 11445568, 11790844, 15878744, 16467158, 17563070, 18556473, 18694973, 19015532, 19475663, 20421596, 20698575, 21195086, 22174920, 22206987, 22500019, 22734583, 23086037, 23133593, 23256729, 23388629, 24218609, 24654599, 24703313, 25531836, 2639135, 26453203, 26453205, 2651160, 2690069, 27607147, 27854243, 28661686, 28684415, 28851981, 29526462, 30014749, 30015901, 31705766, 31768548, 31922743, 31947546, 32929282, 3317417, 34044067, 34882862, 35210421, 36835187, 36967805, 38367541, 39174611, 9560308
Diffuse Neurofibrillary Tangles with Calcification	Associate	36835187
Drug Related Side Effects and Adverse Reactions	Inhibit	16467158
Drug Related Side Effects and Adverse Reactions	Associate	18556473, 21195086, 29526462, 31922743
Drug Related Side Effects and Adverse Reactions	Stimulate	30015901, 31947546
Gastrinoma	Associate	8317551
Gastro enteropancreatic neuroendocrine tumor	Associate	8317551
Gingival Diseases	Associate	33934404
Heart Diseases	Associate	29526462
Herpes Zoster	Associate	32385803
Hippocampal Sclerosis	Associate	27815632, 30682540
Inflammation	Associate	37544243
Insulin Resistance	Associate	33832546, 39174611, 9560308
Insulinoma	Associate	16869889, 20421596, 2365085, 2639135, 2651160, 3053705, 3181427, 8317551
Intervertebral Disc Degeneration	Inhibit	28433710
Islet cell tumor syndrome	Associate	34614009
Melanoma	Associate	28337955
Metabolic Syndrome	Associate	20807286
Microphthalmia Syndromic 10	Associate	27815632
Myotonic Dystrophy	Associate	20421596
Neointima	Associate	11445568, 18694973, 21195086, 22206987, 23256729, 24703313, 25531836, 31705766, 31768548, 38367541
Neoplasms	Associate	33500359, 8317551
Neurodegenerative Diseases	Associate	33832546
Neurologic Manifestations	Associate	34759019
Obesity	Associate	26911465
Osteoporosis	Associate	37361541
Pancreatic Neoplasms	Associate	2690069
Pancreatitis	Associate	16467158, 3181427, 31922743
Parkinson Disease	Associate	34882862
Plaque Amyloid	Associate	10931181, 27607147
Plaque Amyloid	Stimulate	11395927
Prostatic Neoplasms	Associate	36774376
Protein Aggregation Pathological	Associate	16467158
Renal Insufficiency	Associate	29526462
Tauopathies	Associate	34759019
Varicella Zoster Virus Infection	Stimulate	34759019
Ventricular Fibrillation	Associate	19475663