Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	3363
Gene name	5-hydroxytryptamine receptor 7
Gene symbol	HTR7
Synonyms (NCBI Gene)	5-HT7
Chromosome	10
Chromosome location	10q23.31
Summary	The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involveme

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016917	hsa-miR-335-5p	Microarray	18185580
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT528507	hsa-miR-1246	PAR-CLIP	21572407
MIRT528506	hsa-miR-490-5p	PAR-CLIP	21572407
MIRT528505	hsa-miR-4301	PAR-CLIP	21572407
MIRT540122	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT528504	hsa-miR-3167	PAR-CLIP	21572407
MIRT528503	hsa-miR-876-5p	PAR-CLIP	21572407
MIRT528501	hsa-miR-1290	PAR-CLIP	21572407
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	21572407
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT528499	hsa-miR-4666b	PAR-CLIP	21572407
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	21572407
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	21572407
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	21572407
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	21572407
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	22012620
MIRT528507	hsa-miR-1246	PAR-CLIP	22012620
MIRT528506	hsa-miR-490-5p	PAR-CLIP	22012620
MIRT528505	hsa-miR-4301	PAR-CLIP	22012620
MIRT528504	hsa-miR-3167	PAR-CLIP	22012620
MIRT528503	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT528501	hsa-miR-1290	PAR-CLIP	22012620
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	22012620
MIRT528499	hsa-miR-4666b	PAR-CLIP	22012620
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	22012620
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	22012620
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	22012620
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	22012620
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT528507	hsa-miR-1246	PAR-CLIP	21572407
MIRT528506	hsa-miR-490-5p	PAR-CLIP	21572407
MIRT528505	hsa-miR-4301	PAR-CLIP	21572407
MIRT540122	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT528504	hsa-miR-3167	PAR-CLIP	21572407
MIRT528503	hsa-miR-876-5p	PAR-CLIP	21572407
MIRT528501	hsa-miR-1290	PAR-CLIP	21572407
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	21572407
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT528499	hsa-miR-4666b	PAR-CLIP	21572407
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	21572407
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	21572407
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	21572407
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	21572407
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	22012620
MIRT528507	hsa-miR-1246	PAR-CLIP	22012620
MIRT528506	hsa-miR-490-5p	PAR-CLIP	22012620
MIRT528505	hsa-miR-4301	PAR-CLIP	22012620
MIRT528504	hsa-miR-3167	PAR-CLIP	22012620
MIRT528503	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT528501	hsa-miR-1290	PAR-CLIP	22012620
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	22012620
MIRT528499	hsa-miR-4666b	PAR-CLIP	22012620
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	22012620
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	22012620
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	22012620
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	22012620
MIRT1057332	hsa-miR-371-3p	CLIP-seq
MIRT1057333	hsa-miR-371b-3p	CLIP-seq
MIRT1057334	hsa-miR-376c	CLIP-seq
MIRT1057335	hsa-miR-515-3p	CLIP-seq
MIRT1057336	hsa-miR-519e	CLIP-seq
MIRT1057337	hsa-miR-1301	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057341	hsa-miR-3065-5p	CLIP-seq
MIRT1057342	hsa-miR-324-5p	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057344	hsa-miR-3910	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057347	hsa-miR-4660	CLIP-seq
MIRT1057348	hsa-miR-5047	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT2245384	hsa-miR-3148	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT2451474	hsa-miR-3662	CLIP-seq
MIRT2451475	hsa-miR-3674	CLIP-seq
MIRT2451476	hsa-miR-4312	CLIP-seq
MIRT2451477	hsa-miR-4693-3p	CLIP-seq
MIRT2451478	hsa-miR-4712-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IDA	8226867, 35714614
GO:0004993	Function	G protein-coupled serotonin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	19486527, 30021884
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22448645
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IDA
GO:0006939	Process	Smooth muscle contraction	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8226867
GO:0007192	Process	Adenylate cyclase-activating serotonin receptor signaling pathway	IDA	17110384
GO:0007192	Process	Adenylate cyclase-activating serotonin receptor signaling pathway	IDA	8226867, 35714614
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	8226867
GO:0007623	Process	Circadian rhythm	IEA
GO:0007623	Process	Circadian rhythm	TAS	8398139
GO:0008015	Process	Blood circulation	TAS	8226867
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042310	Process	Vasoconstriction	IEA
GO:0045202	Component	Synapse	IEA
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA
GO:0099589	Function	Serotonin receptor activity	IDA	35714614

MIM	HGNC	e!Ensembl
182137	5302	ENSG00000148680

P34969

Protein name

5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7)

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signali

PDB

7XTC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	98 → 384	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: [Isoform A]: Predominant isoform in spleen, caudate and hippocampus. {ECO:0000269|PubMed:9084407}.; TISSUE SPECIFICITY: [Isoform B]: Expressed at lower levels. {ECO:0000269|PubMed:9084407}.; TISSUE SPECIFICITY: [Isoform D]: Minor isofo

Sequence

MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD

Sequence length

479

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Calcium signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

HTR7 (5-hydroxytryptamine receptor 7)