Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3363
Gene name Gene Name - the full gene name approved by the HGNC.	5-hydroxytryptamine receptor 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HTR7
Synonyms (NCBI Gene) Gene synonyms aliases	5-HT7
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q23.31
Summary Summary of gene provided in NCBI Entrez Gene.	The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involveme

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016917	hsa-miR-335-5p	Microarray	18185580
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT528507	hsa-miR-1246	PAR-CLIP	21572407
MIRT528506	hsa-miR-490-5p	PAR-CLIP	21572407
MIRT528505	hsa-miR-4301	PAR-CLIP	21572407
MIRT540122	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT528504	hsa-miR-3167	PAR-CLIP	21572407
MIRT528503	hsa-miR-876-5p	PAR-CLIP	21572407
MIRT528501	hsa-miR-1290	PAR-CLIP	21572407
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	21572407
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT528499	hsa-miR-4666b	PAR-CLIP	21572407
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	21572407
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	21572407
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	21572407
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	21572407
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	22012620
MIRT528507	hsa-miR-1246	PAR-CLIP	22012620
MIRT528506	hsa-miR-490-5p	PAR-CLIP	22012620
MIRT528505	hsa-miR-4301	PAR-CLIP	22012620
MIRT528504	hsa-miR-3167	PAR-CLIP	22012620
MIRT528503	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT528501	hsa-miR-1290	PAR-CLIP	22012620
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	22012620
MIRT528499	hsa-miR-4666b	PAR-CLIP	22012620
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	22012620
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	22012620
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	22012620
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	22012620
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT528507	hsa-miR-1246	PAR-CLIP	21572407
MIRT528506	hsa-miR-490-5p	PAR-CLIP	21572407
MIRT528505	hsa-miR-4301	PAR-CLIP	21572407
MIRT540122	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT528504	hsa-miR-3167	PAR-CLIP	21572407
MIRT528503	hsa-miR-876-5p	PAR-CLIP	21572407
MIRT528501	hsa-miR-1290	PAR-CLIP	21572407
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	21572407
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT528499	hsa-miR-4666b	PAR-CLIP	21572407
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	21572407
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	21572407
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	21572407
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	21572407
MIRT528508	hsa-miR-5580-3p	PAR-CLIP	22012620
MIRT528507	hsa-miR-1246	PAR-CLIP	22012620
MIRT528506	hsa-miR-490-5p	PAR-CLIP	22012620
MIRT528505	hsa-miR-4301	PAR-CLIP	22012620
MIRT528504	hsa-miR-3167	PAR-CLIP	22012620
MIRT528503	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT528501	hsa-miR-1290	PAR-CLIP	22012620
MIRT528502	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT528500	hsa-miR-5011-3p	PAR-CLIP	22012620
MIRT528499	hsa-miR-4666b	PAR-CLIP	22012620
MIRT528498	hsa-miR-4520-3p	PAR-CLIP	22012620
MIRT528497	hsa-miR-4520-2-3p	PAR-CLIP	22012620
MIRT528496	hsa-miR-4529-3p	PAR-CLIP	22012620
MIRT528495	hsa-miR-7850-5p	PAR-CLIP	22012620
MIRT1057332	hsa-miR-371-3p	CLIP-seq
MIRT1057333	hsa-miR-371b-3p	CLIP-seq
MIRT1057334	hsa-miR-376c	CLIP-seq
MIRT1057335	hsa-miR-515-3p	CLIP-seq
MIRT1057336	hsa-miR-519e	CLIP-seq
MIRT1057337	hsa-miR-1301	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057341	hsa-miR-3065-5p	CLIP-seq
MIRT1057342	hsa-miR-324-5p	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057344	hsa-miR-3910	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057347	hsa-miR-4660	CLIP-seq
MIRT1057348	hsa-miR-5047	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT2245384	hsa-miR-3148	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT1057338	hsa-miR-29a	CLIP-seq
MIRT1057339	hsa-miR-29b	CLIP-seq
MIRT1057340	hsa-miR-29c	CLIP-seq
MIRT1057343	hsa-miR-330-3p	CLIP-seq
MIRT1057345	hsa-miR-4520a-3p	CLIP-seq
MIRT1057346	hsa-miR-4520b-3p	CLIP-seq
MIRT1057349	hsa-miR-518a-5p	CLIP-seq
MIRT1057350	hsa-miR-527	CLIP-seq
MIRT2451474	hsa-miR-3662	CLIP-seq
MIRT2451475	hsa-miR-3674	CLIP-seq
MIRT2451476	hsa-miR-4312	CLIP-seq
MIRT2451477	hsa-miR-4693-3p	CLIP-seq
MIRT2451478	hsa-miR-4712-3p	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IDA	8226867, 35714614
GO:0004993	Function	G protein-coupled serotonin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	19486527, 30021884
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22448645
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IDA
GO:0006939	Process	Smooth muscle contraction	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8226867
GO:0007192	Process	Adenylate cyclase-activating serotonin receptor signaling pathway	IDA	17110384
GO:0007192	Process	Adenylate cyclase-activating serotonin receptor signaling pathway	IDA	8226867, 35714614
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	8226867
GO:0007623	Process	Circadian rhythm	IEA
GO:0007623	Process	Circadian rhythm	TAS	8398139
GO:0008015	Process	Blood circulation	TAS	8226867
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042310	Process	Vasoconstriction	IEA
GO:0045202	Component	Synapse	IEA
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA
GO:0099589	Function	Serotonin receptor activity	IDA	35714614

MIM	HGNC	e!Ensembl
182137	5302	ENSG00000148680

Protein

UniProt ID

P34969

Protein name

5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7)

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signali

PDB

7XTC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	98 → 384	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: [Isoform A]: Predominant isoform in spleen, caudate and hippocampus. {ECO:0000269|PubMed:9084407}.; TISSUE SPECIFICITY: [Isoform B]: Expressed at lower levels. {ECO:0000269|PubMed:9084407}.; TISSUE SPECIFICITY: [Isoform D]: Minor isofo

Sequence

MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD

Sequence length

479

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway Calcium signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Glioblastoma	Glioblastoma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alcoholism	Associate	21184583
Mental Disorders	Associate	7601444
Migraine Disorders	Associate	22678113

HTR7 (5-hydroxytryptamine receptor 7)