Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3361
Gene name Gene Name - the full gene name approved by the HGNC.	5-hydroxytryptamine receptor 5A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HTR5A
Synonyms (NCBI Gene) Gene synonyms aliases	5-HT5A
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q36.2
Summary Summary of gene provided in NCBI Entrez Gene.	The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotoni

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miRTarBase ID	miRNA	Experiments
MIRT1057302	hsa-miR-1224-5p	CLIP-seq
MIRT1057303	hsa-miR-1304	CLIP-seq
MIRT1057304	hsa-miR-216a	CLIP-seq
MIRT1057305	hsa-miR-216b	CLIP-seq
MIRT1057306	hsa-miR-3120-5p	CLIP-seq
MIRT1057307	hsa-miR-3125	CLIP-seq
MIRT1057308	hsa-miR-3150b-3p	CLIP-seq
MIRT1057309	hsa-miR-3169	CLIP-seq
MIRT1057310	hsa-miR-3646	CLIP-seq
MIRT1057311	hsa-miR-3662	CLIP-seq
MIRT1057312	hsa-miR-3674	CLIP-seq
MIRT1057313	hsa-miR-3915	CLIP-seq
MIRT1057314	hsa-miR-3916	CLIP-seq
MIRT1057315	hsa-miR-3977	CLIP-seq
MIRT1057316	hsa-miR-4273	CLIP-seq
MIRT1057317	hsa-miR-4283	CLIP-seq
MIRT1057318	hsa-miR-4317	CLIP-seq
MIRT1057319	hsa-miR-433	CLIP-seq
MIRT1057320	hsa-miR-4489	CLIP-seq
MIRT1057321	hsa-miR-4515	CLIP-seq
MIRT1057322	hsa-miR-4677-5p	CLIP-seq
MIRT1057323	hsa-miR-4689	CLIP-seq
MIRT1057324	hsa-miR-4698	CLIP-seq
MIRT1057325	hsa-miR-4732-5p	CLIP-seq
MIRT1057326	hsa-miR-4784	CLIP-seq
MIRT1057327	hsa-miR-488	CLIP-seq
MIRT1057328	hsa-miR-511	CLIP-seq
MIRT1057329	hsa-miR-548g	CLIP-seq
MIRT1057330	hsa-miR-618	CLIP-seq
MIRT1057331	hsa-miR-877	CLIP-seq
MIRT2013096	hsa-miR-208a	CLIP-seq
MIRT2013097	hsa-miR-208b	CLIP-seq
MIRT2013098	hsa-miR-3617	CLIP-seq
MIRT2013099	hsa-miR-3658	CLIP-seq
MIRT2013100	hsa-miR-4312	CLIP-seq
MIRT2013101	hsa-miR-499-5p	CLIP-seq
MIRT2013102	hsa-miR-617	CLIP-seq
MIRT2013103	hsa-miR-641	CLIP-seq
MIRT1057308	hsa-miR-3150b-3p	CLIP-seq
MIRT1057323	hsa-miR-4689	CLIP-seq
MIRT1057326	hsa-miR-4784	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001586	Function	Gi/o-coupled serotonin receptor activity	IDA	9865521, 35610220, 35835867
GO:0001586	Function	Gi/o-coupled serotonin receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IDA	7988681
GO:0004993	Function	G protein-coupled serotonin receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	TAS	7988681
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	9865521
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	9865521
GO:0005886	Component	Plasma membrane	TAS	7988681
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	7988681
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA	34239069
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA	9865521, 35610220
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IEA
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030425	Component	Dendrite	IEA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0032355	Process	Response to estradiol	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0099589	Function	Serotonin receptor activity	IDA	9865521
GO:0099589	Function	Serotonin receptor activity	IEA
GO:0099634	Component	Postsynaptic specialization membrane	IEA

MIM	HGNC	e!Ensembl
601305	5300	ENSG00000157219

Protein

UniProt ID

P47898

Protein name

5-hydroxytryptamine receptor 5A (5-HT-5) (5-HT-5A) (5-HT5A) (Serotonin receptor 5A)

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35610220, PubMed:35835867, PubMed:9865521). Also functions as a receptor for ergot alkaloid

PDB

7UM4 , 7UM5 , 7UM6 , 7UM7 , 7X5H

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	57 → 338	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLL
VLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIAC
DVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFG
WGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVS
PISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIP
FFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH

Sequence length

357

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse		Serotonin receptors G alpha (i) signalling events

HTR5A (5-hydroxytryptamine receptor 5A)