Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3358
Gene name Gene Name - the full gene name approved by the HGNC.	5-hydroxytryptamine receptor 2C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HTR2C
Synonyms (NCBI Gene) Gene synonyms aliases	5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1414334	C>G	Drug-response, benign	Intron variant
rs3813929	C>G,T	Drug-response	Upstream transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005901	hsa-miR-22-3p	Luciferase reporter assay, Microarray	21168126
MIRT1057223	hsa-miR-1324	CLIP-seq
MIRT1057224	hsa-miR-3120-3p	CLIP-seq
MIRT1057225	hsa-miR-323-3p	CLIP-seq
MIRT1057226	hsa-miR-3529	CLIP-seq
MIRT1057227	hsa-miR-3714	CLIP-seq
MIRT1057228	hsa-miR-379	CLIP-seq
MIRT1057229	hsa-miR-3927	CLIP-seq
MIRT1057230	hsa-miR-3942-3p	CLIP-seq
MIRT1057231	hsa-miR-3942-5p	CLIP-seq
MIRT1057232	hsa-miR-4699-3p	CLIP-seq
MIRT1057233	hsa-miR-4703-5p	CLIP-seq
MIRT1057234	hsa-miR-4708-3p	CLIP-seq
MIRT1057235	hsa-miR-4736	CLIP-seq
MIRT1057236	hsa-miR-4742-5p	CLIP-seq
MIRT1057237	hsa-miR-940	CLIP-seq
MIRT2013074	hsa-miR-1290	CLIP-seq
MIRT2013075	hsa-miR-4263	CLIP-seq
MIRT2013076	hsa-miR-450b-5p	CLIP-seq
MIRT2013077	hsa-miR-4719	CLIP-seq
MIRT2013078	hsa-miR-4802-3p	CLIP-seq
MIRT2013079	hsa-miR-513b	CLIP-seq
MIRT2013080	hsa-miR-555	CLIP-seq
MIRT2245370	hsa-miR-1252	CLIP-seq
MIRT1057223	hsa-miR-1324	CLIP-seq
MIRT1057224	hsa-miR-3120-3p	CLIP-seq
MIRT1057230	hsa-miR-3942-3p	CLIP-seq
MIRT1057231	hsa-miR-3942-5p	CLIP-seq
MIRT1057232	hsa-miR-4699-3p	CLIP-seq
MIRT1057233	hsa-miR-4703-5p	CLIP-seq
MIRT2451471	hsa-miR-4677-3p	CLIP-seq
MIRT2451472	hsa-miR-495	CLIP-seq
MIRT2451473	hsa-miR-610	CLIP-seq
MIRT2548615	hsa-miR-3130-3p	CLIP-seq
MIRT2548616	hsa-miR-3664-5p	CLIP-seq
MIRT2548617	hsa-miR-4714-5p	CLIP-seq
MIRT2548618	hsa-miR-4793-3p	CLIP-seq
MIRT2548619	hsa-miR-568	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001587	Function	Gq/11-coupled serotonin receptor activity	IDA	18703043, 29398112
GO:0001662	Process	Behavioral fear response	IEA
GO:0001662	Process	Behavioral fear response	ISS
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IDA	7582481, 12970106
GO:0004993	Function	G protein-coupled serotonin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	14988405, 25770211, 28258217, 28514442, 30157263, 32296183, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12970106, 18703043
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	18703043
GO:0005886	Component	Plasma membrane	TAS
GO:0006874	Process	Intracellular calcium ion homeostasis	IDA	19057895
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007208	Process	Phospholipase C-activating serotonin receptor signaling pathway	IBA
GO:0007208	Process	Phospholipase C-activating serotonin receptor signaling pathway	IDA	20966218, 37991948
GO:0007208	Process	Phospholipase C-activating serotonin receptor signaling pathway	IDA	12970106, 29398112
GO:0007208	Process	Phospholipase C-activating serotonin receptor signaling pathway	IEA
GO:0007208	Process	Phospholipase C-activating serotonin receptor signaling pathway	ISS
GO:0007210	Process	Serotonin receptor signaling pathway	IBA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	TAS	9241279
GO:0007626	Process	Locomotory behavior	IEA
GO:0007631	Process	Feeding behavior	IEA
GO:0007631	Process	Feeding behavior	ISS
GO:0007631	Process	Feeding behavior	TAS	7700379
GO:0010513	Process	Positive regulation of phosphatidylinositol biosynthetic process	IDA	19057895
GO:0016020	Component	Membrane	IEA
GO:0019934	Process	CGMP-mediated signaling	IDA	12970106
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0031644	Process	Regulation of nervous system process	IEA
GO:0031644	Process	Regulation of nervous system process	ISS
GO:0032098	Process	Regulation of appetite	IEA
GO:0032098	Process	Regulation of appetite	ISS
GO:0042802	Function	Identical protein binding	IPI	15518545, 16195233, 25770211, 28258217
GO:0043397	Process	Regulation of corticotropin-releasing hormone secretion	IEA
GO:0043397	Process	Regulation of corticotropin-releasing hormone secretion	ISS
GO:0045202	Component	Synapse	IEA
GO:0045600	Process	Positive regulation of fat cell differentiation	IEA
GO:0050850	Process	Positive regulation of calcium-mediated signaling	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IMP	18703043
GO:0051378	Function	Serotonin binding	IDA	7582481, 12970106, 15831837, 18703043, 19057895
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	19057895
GO:0071886	Function	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	IDA	19057895
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IDA	18703043
GO:0098666	Component	G protein-coupled serotonin receptor complex	IDA	12970106, 18703043
GO:0099589	Function	Serotonin receptor activity	IDA	29398112
GO:0099589	Function	Serotonin receptor activity	IEA

MIM	HGNC	e!Ensembl
312861	5295	ENSG00000147246

Protein

UniProt ID

P28335

Protein name

5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:12970106, PubMed:18703043, PubMed:19057895, PubMed:29398112, PubMed:7895773). Also functions as a receptor for various drugs and psychoactive substances, including ergot alka

PDB

6BQG , 6BQH , 8DPF , 8DPG , 8DPH , 8DPI , 8ZMF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	70 → 368	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain. {ECO:0000269|PubMed:8812491}.

Sequence

MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV

Sequence length

458

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction Serotonergic synapse Inflammatory mediator regulation of TRP channels		Serotonin receptors G alpha (q) signalling events

HTR2C (5-hydroxytryptamine receptor 2C)