Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3355
Gene name Gene Name - the full gene name approved by the HGNC.	5-hydroxytryptamine receptor 1F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HTR1F
Synonyms (NCBI Gene) Gene synonyms aliases	5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p11.2-p11.1

Show/Hide all(117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT663891	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT663890	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT663889	hsa-miR-4518	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT663891	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT663890	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT663889	hsa-miR-4518	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT647681	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT647680	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT647679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647678	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647677	hsa-miR-4287	HITS-CLIP	23824327
MIRT647676	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT647675	hsa-miR-3934-3p	HITS-CLIP	23824327
MIRT647673	hsa-miR-4268	HITS-CLIP	23824327
MIRT647674	hsa-miR-4448	HITS-CLIP	23824327
MIRT647672	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT647671	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT647670	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT647669	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT647668	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT647667	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT1057170	hsa-miR-105	CLIP-seq
MIRT1057171	hsa-miR-1252	CLIP-seq
MIRT1057172	hsa-miR-3153	CLIP-seq
MIRT1057173	hsa-miR-3168	CLIP-seq
MIRT1057174	hsa-miR-3671	CLIP-seq
MIRT1057175	hsa-miR-4282	CLIP-seq
MIRT1057176	hsa-miR-4476	CLIP-seq
MIRT1057177	hsa-miR-4533	CLIP-seq
MIRT1057178	hsa-miR-4728-3p	CLIP-seq
MIRT1057179	hsa-miR-4799-5p	CLIP-seq
MIRT1057180	hsa-miR-513a-3p	CLIP-seq
MIRT1057181	hsa-miR-548a-5p	CLIP-seq
MIRT1057182	hsa-miR-548ab	CLIP-seq
MIRT1057183	hsa-miR-548ag	CLIP-seq
MIRT1057184	hsa-miR-548ai	CLIP-seq
MIRT1057185	hsa-miR-548ak	CLIP-seq
MIRT1057186	hsa-miR-548b-5p	CLIP-seq
MIRT1057187	hsa-miR-548c-3p	CLIP-seq
MIRT1057188	hsa-miR-548c-5p	CLIP-seq
MIRT1057189	hsa-miR-548d-5p	CLIP-seq
MIRT1057190	hsa-miR-548h	CLIP-seq
MIRT1057191	hsa-miR-548i	CLIP-seq
MIRT1057192	hsa-miR-548j	CLIP-seq
MIRT1057193	hsa-miR-548k	CLIP-seq
MIRT1057194	hsa-miR-548l	CLIP-seq
MIRT1057195	hsa-miR-548w	CLIP-seq
MIRT1057196	hsa-miR-548y	CLIP-seq
MIRT1057197	hsa-miR-559	CLIP-seq
MIRT1057198	hsa-miR-607	CLIP-seq
MIRT1057199	hsa-miR-873	CLIP-seq
MIRT2013071	hsa-miR-2964a-3p	CLIP-seq
MIRT2013072	hsa-miR-302f	CLIP-seq
MIRT2389212	hsa-miR-1321	CLIP-seq
MIRT2389213	hsa-miR-202	CLIP-seq
MIRT2389214	hsa-miR-2053	CLIP-seq
MIRT1057174	hsa-miR-3671	CLIP-seq
MIRT2389215	hsa-miR-4419a	CLIP-seq
MIRT2389216	hsa-miR-4510	CLIP-seq
MIRT2389217	hsa-miR-4739	CLIP-seq
MIRT2389218	hsa-miR-4756-5p	CLIP-seq
MIRT2389219	hsa-miR-4781-3p	CLIP-seq
MIRT2389220	hsa-miR-4802-5p	CLIP-seq
MIRT2389221	hsa-miR-567	CLIP-seq
MIRT2389222	hsa-miR-569	CLIP-seq
MIRT1057198	hsa-miR-607	CLIP-seq
MIRT2429708	hsa-miR-3646	CLIP-seq
MIRT2548586	hsa-miR-4768-3p	CLIP-seq
MIRT2548587	hsa-miR-539	CLIP-seq
MIRT2429708	hsa-miR-3646	CLIP-seq
MIRT2548586	hsa-miR-4768-3p	CLIP-seq
MIRT2548587	hsa-miR-539	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001586	Function	Gi/o-coupled serotonin receptor activity	IDA	34239069
GO:0001586	Function	Gi/o-coupled serotonin receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IDA	8380639
GO:0004993	Function	G protein-coupled serotonin receptor activity	IEA
GO:0004993	Function	G protein-coupled serotonin receptor activity	IMP	21422162
GO:0004993	Function	G protein-coupled serotonin receptor activity	TAS	8380639
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	21422162
GO:0005886	Component	Plasma membrane	TAS	8380639
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	8380639
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	21422162
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA	34239069, 35610220, 35835867
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IEA
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	TAS	8380639
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0045202	Component	Synapse	IEA
GO:0051378	Function	Serotonin binding	IDA	8380639
GO:0051378	Function	Serotonin binding	IEA
GO:0099589	Function	Serotonin receptor activity	IDA	34239069
GO:0099589	Function	Serotonin receptor activity	IEA

MIM	HGNC	e!Ensembl
182134	5292	ENSG00000179097

Protein

UniProt ID

P30939

Protein name

5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F)

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:21422162, PubMed:8380639, P

PDB

7EXD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	40 → 347	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANY
LICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALD
RYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIV
STIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKS
VSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG
AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQK
LVRCRC

Sequence length

366

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction		Serotonin receptors G alpha (i) signalling events

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Insomnia	Insomnia, Insomnia (standard GWA)	N/A	N/A	GWAS

HTR1F (5-hydroxytryptamine receptor 1F)