Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3352
Gene name Gene Name - the full gene name approved by the HGNC.	5-hydroxytryptamine receptor 1D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HTR1D
Synonyms (NCBI Gene) Gene synonyms aliases	5-HT1D, HT1DA, HTR1DA, HTRL, RDC4
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.12

Show/Hide all(153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019223	hsa-miR-335-5p	Microarray	18185580
MIRT042672	hsa-miR-196b-5p	CLASH	23622248
MIRT1057136	hsa-miR-128	CLIP-seq
MIRT1057137	hsa-miR-24	CLIP-seq
MIRT1057138	hsa-miR-2861	CLIP-seq
MIRT1057139	hsa-miR-31	CLIP-seq
MIRT1057140	hsa-miR-3122	CLIP-seq
MIRT1057141	hsa-miR-3133	CLIP-seq
MIRT1057142	hsa-miR-3148	CLIP-seq
MIRT1057143	hsa-miR-3187-3p	CLIP-seq
MIRT1057144	hsa-miR-3613-3p	CLIP-seq
MIRT1057145	hsa-miR-3616-3p	CLIP-seq
MIRT1057146	hsa-miR-3653	CLIP-seq
MIRT1057147	hsa-miR-3658	CLIP-seq
MIRT1057148	hsa-miR-371-5p	CLIP-seq
MIRT1057149	hsa-miR-371b-5p	CLIP-seq
MIRT1057150	hsa-miR-3913-5p	CLIP-seq
MIRT1057151	hsa-miR-4269	CLIP-seq
MIRT1057152	hsa-miR-4284	CLIP-seq
MIRT1057153	hsa-miR-4299	CLIP-seq
MIRT1057154	hsa-miR-4432	CLIP-seq
MIRT1057155	hsa-miR-4435	CLIP-seq
MIRT1057156	hsa-miR-450b-3p	CLIP-seq
MIRT1057157	hsa-miR-4645-5p	CLIP-seq
MIRT1057158	hsa-miR-4663	CLIP-seq
MIRT1057159	hsa-miR-4673	CLIP-seq
MIRT1057160	hsa-miR-4696	CLIP-seq
MIRT1057161	hsa-miR-4701-5p	CLIP-seq
MIRT1057162	hsa-miR-4728-3p	CLIP-seq
MIRT1057163	hsa-miR-4755-3p	CLIP-seq
MIRT1057164	hsa-miR-4781-3p	CLIP-seq
MIRT1057165	hsa-miR-548s	CLIP-seq
MIRT1057166	hsa-miR-570	CLIP-seq
MIRT1057167	hsa-miR-588	CLIP-seq
MIRT1057168	hsa-miR-642b	CLIP-seq
MIRT1057169	hsa-miR-769-3p	CLIP-seq
MIRT2013053	hsa-miR-1827	CLIP-seq
MIRT2013054	hsa-miR-2114	CLIP-seq
MIRT2013055	hsa-miR-3197	CLIP-seq
MIRT2013056	hsa-miR-335	CLIP-seq
MIRT2013057	hsa-miR-3612	CLIP-seq
MIRT2013058	hsa-miR-3664-5p	CLIP-seq
MIRT2013059	hsa-miR-3674	CLIP-seq
MIRT2013060	hsa-miR-3929	CLIP-seq
MIRT2013061	hsa-miR-4419b	CLIP-seq
MIRT2013062	hsa-miR-4443	CLIP-seq
MIRT2013063	hsa-miR-4478	CLIP-seq
MIRT2013064	hsa-miR-4649-3p	CLIP-seq
MIRT1057158	hsa-miR-4663	CLIP-seq
MIRT2013065	hsa-miR-4714-5p	CLIP-seq
MIRT2013066	hsa-miR-4767	CLIP-seq
MIRT2013067	hsa-miR-4786-5p	CLIP-seq
MIRT2013068	hsa-miR-485-5p	CLIP-seq
MIRT2013069	hsa-miR-516b	CLIP-seq
MIRT2013070	hsa-miR-650	CLIP-seq
MIRT1057136	hsa-miR-128	CLIP-seq
MIRT2245356	hsa-miR-1913	CLIP-seq
MIRT1057137	hsa-miR-24	CLIP-seq
MIRT1057140	hsa-miR-3122	CLIP-seq
MIRT1057143	hsa-miR-3187-3p	CLIP-seq
MIRT2245357	hsa-miR-324-3p	CLIP-seq
MIRT1057150	hsa-miR-3913-5p	CLIP-seq
MIRT1057151	hsa-miR-4269	CLIP-seq
MIRT1057152	hsa-miR-4284	CLIP-seq
MIRT2245358	hsa-miR-4313	CLIP-seq
MIRT1057155	hsa-miR-4435	CLIP-seq
MIRT1057156	hsa-miR-450b-3p	CLIP-seq
MIRT1057157	hsa-miR-4645-5p	CLIP-seq
MIRT1057159	hsa-miR-4673	CLIP-seq
MIRT1057161	hsa-miR-4701-5p	CLIP-seq
MIRT2245359	hsa-miR-4722-3p	CLIP-seq
MIRT1057163	hsa-miR-4755-3p	CLIP-seq
MIRT1057164	hsa-miR-4781-3p	CLIP-seq
MIRT1057165	hsa-miR-548s	CLIP-seq
MIRT1057167	hsa-miR-588	CLIP-seq
MIRT1057169	hsa-miR-769-3p	CLIP-seq
MIRT2013053	hsa-miR-1827	CLIP-seq
MIRT2013054	hsa-miR-2114	CLIP-seq
MIRT2013057	hsa-miR-3612	CLIP-seq
MIRT2013058	hsa-miR-3664-5p	CLIP-seq
MIRT2013059	hsa-miR-3674	CLIP-seq
MIRT2013060	hsa-miR-3929	CLIP-seq
MIRT2013061	hsa-miR-4419b	CLIP-seq
MIRT2013062	hsa-miR-4443	CLIP-seq
MIRT2013063	hsa-miR-4478	CLIP-seq
MIRT2013064	hsa-miR-4649-3p	CLIP-seq
MIRT2013065	hsa-miR-4714-5p	CLIP-seq
MIRT2013068	hsa-miR-485-5p	CLIP-seq
MIRT2013069	hsa-miR-516b	CLIP-seq
MIRT2013070	hsa-miR-650	CLIP-seq
MIRT2451465	hsa-miR-1227	CLIP-seq
MIRT2451466	hsa-miR-18a	CLIP-seq
MIRT2451467	hsa-miR-18b	CLIP-seq
MIRT2451468	hsa-miR-3064-3p	CLIP-seq
MIRT1057144	hsa-miR-3613-3p	CLIP-seq
MIRT1057148	hsa-miR-371-5p	CLIP-seq
MIRT1057149	hsa-miR-371b-5p	CLIP-seq
MIRT1057154	hsa-miR-4432	CLIP-seq
MIRT2451469	hsa-miR-4735-3p	CLIP-seq
MIRT2451470	hsa-miR-4761-5p	CLIP-seq
MIRT2451465	hsa-miR-1227	CLIP-seq
MIRT2451466	hsa-miR-18a	CLIP-seq
MIRT2451467	hsa-miR-18b	CLIP-seq
MIRT2451468	hsa-miR-3064-3p	CLIP-seq
MIRT1057139	hsa-miR-31	CLIP-seq
MIRT1057140	hsa-miR-3122	CLIP-seq
MIRT2013055	hsa-miR-3197	CLIP-seq
MIRT1057144	hsa-miR-3613-3p	CLIP-seq
MIRT1057145	hsa-miR-3616-3p	CLIP-seq
MIRT1057148	hsa-miR-371-5p	CLIP-seq
MIRT1057149	hsa-miR-371b-5p	CLIP-seq
MIRT1057150	hsa-miR-3913-5p	CLIP-seq
MIRT2548581	hsa-miR-4252	CLIP-seq
MIRT1057154	hsa-miR-4432	CLIP-seq
MIRT2548582	hsa-miR-4477a	CLIP-seq
MIRT1057156	hsa-miR-450b-3p	CLIP-seq
MIRT2013064	hsa-miR-4649-3p	CLIP-seq
MIRT1057158	hsa-miR-4663	CLIP-seq
MIRT1057160	hsa-miR-4696	CLIP-seq
MIRT1057162	hsa-miR-4728-3p	CLIP-seq
MIRT2451469	hsa-miR-4735-3p	CLIP-seq
MIRT2451470	hsa-miR-4761-5p	CLIP-seq
MIRT2013066	hsa-miR-4767	CLIP-seq
MIRT2548583	hsa-miR-508-5p	CLIP-seq
MIRT2548584	hsa-miR-548c-3p	CLIP-seq
MIRT2548585	hsa-miR-766	CLIP-seq
MIRT1057169	hsa-miR-769-3p	CLIP-seq
MIRT2451465	hsa-miR-1227	CLIP-seq
MIRT2451466	hsa-miR-18a	CLIP-seq
MIRT2451467	hsa-miR-18b	CLIP-seq
MIRT2451468	hsa-miR-3064-3p	CLIP-seq
MIRT1057139	hsa-miR-31	CLIP-seq
MIRT1057140	hsa-miR-3122	CLIP-seq
MIRT2013055	hsa-miR-3197	CLIP-seq
MIRT1057144	hsa-miR-3613-3p	CLIP-seq
MIRT1057145	hsa-miR-3616-3p	CLIP-seq
MIRT1057148	hsa-miR-371-5p	CLIP-seq
MIRT1057149	hsa-miR-371b-5p	CLIP-seq
MIRT1057150	hsa-miR-3913-5p	CLIP-seq
MIRT2548581	hsa-miR-4252	CLIP-seq
MIRT1057154	hsa-miR-4432	CLIP-seq
MIRT2548582	hsa-miR-4477a	CLIP-seq
MIRT1057156	hsa-miR-450b-3p	CLIP-seq
MIRT2013064	hsa-miR-4649-3p	CLIP-seq
MIRT1057158	hsa-miR-4663	CLIP-seq
MIRT1057160	hsa-miR-4696	CLIP-seq
MIRT1057162	hsa-miR-4728-3p	CLIP-seq
MIRT2451469	hsa-miR-4735-3p	CLIP-seq
MIRT2451470	hsa-miR-4761-5p	CLIP-seq
MIRT2548583	hsa-miR-508-5p	CLIP-seq
MIRT2548584	hsa-miR-548c-3p	CLIP-seq
MIRT2548585	hsa-miR-766	CLIP-seq
MIRT1057169	hsa-miR-769-3p	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA	21873635
GO:0004993	Function	G protein-coupled serotonin receptor activity	IMP	1652050
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	1652050
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	21873635
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	1652050
GO:0007198	Process	Adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0014827	Process	Intestine smooth muscle contraction	IMP	9186750
GO:0030425	Component	Dendrite	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0040012	Process	Regulation of locomotion	IEA
GO:0042310	Process	Vasoconstriction	IEA
GO:0045202	Component	Synapse	IEA
GO:0050795	Process	Regulation of behavior	IEA
GO:0051378	Function	Serotonin binding	IBA	21873635

MIM	HGNC	e!Ensembl
182133	5289	ENSG00000179546

Protein

UniProt ID

P28221

Protein name

5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other

PDB

7E32

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	55 → 356	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain neocortex and caudate nucleus (at protein level). {ECO:0000269|PubMed:1828434}.

Sequence

MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS

Sequence length

377

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction		Serotonin receptors G alpha (i) signalling events

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)	19038234

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Depressive disorder		21937687, 8018797	ClinVar

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Adrenocortical Carcinoma	Associate	34220331
Agnosia	Associate	38482990
Autistic Disorder	Associate	17203304
Bipolar Disorder	Associate	38482990
Breast Neoplasms	Associate	39766808
Cognition Disorders	Stimulate	38482990
Hashimoto Disease	Associate	34493981
Hidradenitis Suppurativa	Associate	39940809
Intellectual Disability	Associate	38482990
Neoplasm Metastasis	Associate	39766808
Neoplasms	Associate	25170871, 25268648
Neoplasms	Inhibit	35813473
Neurocognitive Disorders	Associate	38482990
Pancreatic Neoplasms	Associate	25170871, 25268648, 35813473
Squamous Cell Carcinoma of Head and Neck	Associate	33869632
Stomach Neoplasms	Associate	35785570

HTR1D (5-hydroxytryptamine receptor 1D)