HTR1A (5-hydroxytryptamine receptor 1A)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3350
Gene name Gene Name - the full gene name approved by the HGNC.
5-hydroxytryptamine receptor 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HTR1A
Synonyms (NCBI Gene) Gene synonyms aliases
5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of th
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
SNP ID Visualize variation Clinical significance Consequence
rs6295 C>A,G Likely-benign, benign, drug-response Upstream transcript variant
rs367956927 T>- Pathogenic 5 prime UTR variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT018705 hsa-miR-335-5p Microarray 18185580
MIRT438131 hsa-miR-135a-5p Luciferase reporter assay 24952960
MIRT438131 hsa-miR-135a-5p Luciferase reporter assay 24952960
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
Transcription factor Regulation Reference
DEAF1 Repression 14507979
HES1 Unknown 18499474
HES6 Unknown 18499474
MAZ Unknown 8626793
PARP1 Repression 21990073
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(29)
GO ID Ontology Definition Evidence Reference
GO:0001662 Process Behavioral fear response ISS
GO:0004993 Function G protein-coupled serotonin receptor activity IBA 21873635
GO:0004993 Function G protein-coupled serotonin receptor activity IDA 8393041
GO:0004993 Function G protein-coupled serotonin receptor activity IMP 22957663
GO:0005515 Function Protein binding IPI 20171159, 22035699, 24157794, 25485703, 26365466, 28920103
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
109760 5286 ENSG00000178394
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08908
Protein name 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A)
Protein function G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). Also functions as a receptor for various drugs and psychoactive
PDB 7E2X , 7E2Y , 7E2Z , 8FY8 , 8FYE , 8FYL , 8FYT , 8FYX , 8JSP , 8JT6 , 8PJK , 8PKM , 8W8B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 53 → 400 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:8393041}.
Sequence
Sequence length 422
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
Taste transduction 		  Serotonin receptors
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 21447133
Migraine Migraine Disorders rs794727411
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 24331356
Seizure Complex partial seizures, Generalized seizures, Visual seizure, Tonic - clonic seizures, Single Seizure rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061
View all (179 more)		 12646302, 16313900, 2533336
Show/Hide Unknown Diseases (7)
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder, Major depression, single episode, Unipolar Depression, Depression, Postpartum, Severe depression, Major Depressive Disorder 24337875, 24462335, 24180393, 25106036, 23809646, 16154547, 16395308, 19458612, 21577007, 18387740, 23440462, 24911443, 24607934, 20633050, 22832728 ClinVar
Mental Depression Mental Depression GWAS
Bronchopulmonary Dysplasia Bronchopulmonary Dysplasia GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Show/Hide Text Mining Associations (48)
Associations from Text Mining
Disease Name Relationship Type References
Acute Pain Associate 39615579
Adenocarcinoma Associate 26112163
Agoraphobia Associate 14984628
Alzheimer Disease Associate 25041947
Anemia Sickle Cell Associate 39615579
Anxiety Associate 10585418, 14984628, 19124686, 23408467, 29249830, 33874644
Anxiety Disorders Associate 18796187, 25514753, 37984468
Attention Deficit Disorder with Hyperactivity Associate 26079129
Autistic Disorder Associate 17203304
Autoimmune Diseases Associate 22563461