Gene Gene information from NCBI Gene database.
Entrez ID 3337
Gene name DnaJ heat shock protein family (Hsp40) member B1
Gene symbol DNAJB1
Synonyms (NCBI Gene)
HSPF1Hdj1Hsp40RSPH16BSis1
Chromosome 19
Chromosome location 19p13.12
Summary This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the `J-domain` and function as one of the two major classes of molecular c
miRNA miRNA information provided by mirtarbase database.
620
miRTarBase ID miRNA Experiments Reference
MIRT001553 hsa-miR-155-5p pSILAC 18668040
MIRT001371 hsa-miR-1-3p pSILAC 18668040
MIRT001553 hsa-miR-155-5p Proteomics;Other 18668040
MIRT023313 hsa-miR-122-5p Microarray 17612493
MIRT001371 hsa-miR-1-3p Proteomics;Other 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 9499401
GO:0001671 Function ATPase activator activity IDA 20060297, 23921388, 24318877
GO:0001671 Function ATPase activator activity TAS
GO:0003714 Function Transcription corepressor activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604572 5270 ENSG00000132002
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P25685
Protein name DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)
Protein function Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shoc
PDB 1HDJ , 2QLD , 3AGX , 3AGY , 3AGZ , 4WB7 , 6BYR , 6WJF , 6WJG , 6Z5N , 7NDX , 8FE2 , 8FE5 , 8FEC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ 4 65 DnaJ domain Domain
PF01556 DnaJ_C 164 323 DnaJ C terminal domain Domain
Sequence
Sequence length 340
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum
Influenza A
  Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
MAPK6/MAPK4 signaling