Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3337
Gene name Gene Name - the full gene name approved by the HGNC.
DnaJ heat shock protein family (Hsp40) member B1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DNAJB1
Synonyms (NCBI Gene) Gene synonyms aliases
HSPF1, Hdj1, Hsp40, RSPH16B, Sis1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the `J-domain` and function as one of the two major classes of molecular c
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001553 hsa-miR-155-5p pSILAC 18668040
MIRT001371 hsa-miR-1-3p pSILAC 18668040
MIRT001553 hsa-miR-155-5p Proteomics;Other 18668040
MIRT023313 hsa-miR-122-5p Microarray 17612493
MIRT001371 hsa-miR-1-3p Proteomics;Other 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0001671 Function ATPase activator activity IDA 20060297, 23921388, 24318877
GO:0003714 Function Transcription corepressor activity IBA 21873635
GO:0003714 Function Transcription corepressor activity IDA 9499401
GO:0005515 Function Protein binding IPI 9499401, 17024176, 21044950, 23921388, 27120771, 28514442, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604572 5270 ENSG00000132002
Protein
UniProt ID P25685
Protein name DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)
Protein function Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shoc
PDB 1HDJ , 2QLD , 3AGX , 3AGY , 3AGZ , 4WB7 , 6BYR , 6WJF , 6WJG , 6Z5N , 7NDX , 8FE2 , 8FE5 , 8FEC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ 4 65 DnaJ domain Domain
PF01556 DnaJ_C 164 323 DnaJ C terminal domain Domain
Sequence
Sequence length 340
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein processing in endoplasmic reticulum
Influenza A
  Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
MAPK6/MAPK4 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hepatocellular carcinoma Fibrolamellar Hepatocellular Carcinoma, Fibrolamellar hepatocellular carcinoma rs397514032, rs587776627, rs587776665, rs28934571, rs121912654, rs121913279, rs587776802, rs121913274, rs121913675, rs121913676, rs121913677, rs78014899, rs121434587, rs121434588, rs121913407
View all (7 more)
24578576
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 34884786
Adenocarcinoma Associate 35322195
Atherosclerosis Associate 39735968
Brain Infarction Associate 39735968
Carcinoma Hepatocellular Associate 27029710, 31862487
Carney Complex Associate 29222914
Cerebral Infarction Associate 39735968
Cholangiocarcinoma Stimulate 31661142
Colitis Ulcerative Associate 15080017
Colorectal Neoplasms Associate 33787596