HSPE1 (heat shock protein family E (Hsp10) member 1)

Gene

• Entrez ID: 3336
• Gene name: Heat shock protein family E (Hsp10) member 1
• Gene symbol: HSPE1
• Synonyms (NCBI Gene): CPN10, EPF, GROES, HSP10
• Chromosome: 2
• Chromosome location: 2q33.1
• Summary: This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an A

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1056772	hsa-miR-1	CLIP-seq
MIRT1056773	hsa-miR-103a	CLIP-seq
MIRT1056774	hsa-miR-107	CLIP-seq
MIRT1056775	hsa-miR-1243	CLIP-seq
MIRT1056776	hsa-miR-1270	CLIP-seq
MIRT1056777	hsa-miR-206	CLIP-seq
MIRT1056778	hsa-miR-3074-3p	CLIP-seq
MIRT1056779	hsa-miR-3163	CLIP-seq
MIRT1056780	hsa-miR-340	CLIP-seq
MIRT1056781	hsa-miR-3673	CLIP-seq
MIRT1056782	hsa-miR-3688-3p	CLIP-seq
MIRT1056783	hsa-miR-3942-3p	CLIP-seq
MIRT1056784	hsa-miR-4261	CLIP-seq
MIRT1056785	hsa-miR-4276	CLIP-seq
MIRT1056786	hsa-miR-4311	CLIP-seq
MIRT1056787	hsa-miR-4496	CLIP-seq
MIRT1056788	hsa-miR-4531	CLIP-seq
MIRT1056789	hsa-miR-4666-5p	CLIP-seq
MIRT1056790	hsa-miR-4699-3p	CLIP-seq
MIRT1056791	hsa-miR-4764-5p	CLIP-seq
MIRT1056792	hsa-miR-4795-3p	CLIP-seq
MIRT1056793	hsa-miR-539	CLIP-seq
MIRT1056794	hsa-miR-613	CLIP-seq
MIRT1056795	hsa-miR-616	CLIP-seq
MIRT1056796	hsa-miR-620	CLIP-seq
MIRT1056797	hsa-miR-624	CLIP-seq
MIRT1056798	hsa-miR-944	CLIP-seq
MIRT1056772	hsa-miR-1	CLIP-seq
MIRT1056773	hsa-miR-103a	CLIP-seq
MIRT1056774	hsa-miR-107	CLIP-seq
MIRT1056777	hsa-miR-206	CLIP-seq
MIRT1056781	hsa-miR-3673	CLIP-seq
MIRT1056783	hsa-miR-3942-3p	CLIP-seq
MIRT1056785	hsa-miR-4276	CLIP-seq
MIRT1056789	hsa-miR-4666-5p	CLIP-seq
MIRT1056790	hsa-miR-4699-3p	CLIP-seq
MIRT1056794	hsa-miR-613	CLIP-seq
MIRT1056798	hsa-miR-944	CLIP-seq
MIRT1056772	hsa-miR-1	CLIP-seq
MIRT1056773	hsa-miR-103a	CLIP-seq
MIRT1056774	hsa-miR-107	CLIP-seq
MIRT1056777	hsa-miR-206	CLIP-seq
MIRT1056781	hsa-miR-3673	CLIP-seq
MIRT1056783	hsa-miR-3942-3p	CLIP-seq
MIRT1056785	hsa-miR-4276	CLIP-seq
MIRT1056789	hsa-miR-4666-5p	CLIP-seq
MIRT1056790	hsa-miR-4699-3p	CLIP-seq
MIRT1056794	hsa-miR-613	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	9989505, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	10205158
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IBA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	TAS	7698325
GO:0006986	Process	Response to unfolded protein	TAS	7698325
GO:0016020	Component	Membrane	HDA	16210410
GO:0044183	Function	Protein folding chaperone	IEA
GO:0046872	Function	Metal ion binding	IBA
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	NAS	7916212, 12483302
GO:0051087	Function	Protein-folding chaperone binding	IBA
GO:0051087	Function	Protein-folding chaperone binding	IPI	10205158
GO:0051087	Function	Protein-folding chaperone binding	TAS	7698325
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0097193	Process	Intrinsic apoptotic signaling pathway	NAS	10205158

Other IDs

• MIM: 600141
• HGNC: 5269
• e!Ensembl: ENSG00000115541

Protein

• UniProt ID: P61604
• Protein name: 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1)
• Protein function: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolde
• PDB: 4PJ1, 6HT7, 6MRC, 6MRD, 8G7N, 8G7O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00166	Cpn10	8 → 100	Chaperonin 10 Kd subunit	Domain

• Sequence:

  MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEI
  QPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDGDILGKYVD

• Sequence length: 102