Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3320
Gene name Gene Name - the full gene name approved by the HGNC.
Heat shock protein 90 alpha family class A member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HSP90AA1
Synonyms (NCBI Gene) Gene synonyms aliases
EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020063 hsa-miR-375 Microarray 20215506
MIRT031959 hsa-miR-16-5p Proteomics 18668040
MIRT052238 hsa-let-7b-5p CLASH 23622248
MIRT050979 hsa-miR-17-5p CLASH 23622248
MIRT050304 hsa-miR-25-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
POU4F1 Activation 15818685
POU4F2 Activation 15818685
STAT1 Repression 12940076
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0001934 Process Positive regulation of protein phosphorylation IDA 19363271
GO:0002218 Process Activation of innate immune response IDA 20628368
GO:0002230 Process Positive regulation of defense response to virus by host IDA 20628368
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
140571 5253 ENSG00000080824
Protein
UniProt ID P07900
Protein name Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Protein function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its AT
PDB 1BYQ , 1OSF , 1UY6 , 1UY7 , 1UY8 , 1UY9 , 1UYC , 1UYD , 1UYE , 1UYF , 1UYG , 1UYH , 1UYI , 1UYK , 1UYL , 1YC1 , 1YC3 , 1YC4 , 1YER , 1YES , 1YET , 2BSM , 2BT0 , 2BUG , 2BYH , 2BYI , 2BZ5 , 2C2L , 2CCS , 2CCT , 2CCU , 2FWY , 2FWZ , 2H55 , 2JJC , 2K5B , 2QF6 , 2QFO , 2QG0 , 2QG2 , 2UWD , 2VCI , 2VCJ , 2WI1 , 2WI2 , 2WI3 , 2WI4 , 2WI5 , 2WI6 , 2WI7 , 2XAB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02518 HATPase_c 40 194 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Domain
PF00183 HSP90 196 723 Hsp90 protein Family
Sequence
Sequence length 732
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein processing in endoplasmic reticulum
PI3K-Akt signaling pathway
Necroptosis
Antigen processing and presentation
NOD-like receptor signaling pathway
IL-17 signaling pathway
Th17 cell differentiation
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Salmonella infection
Pathways in cancer
Chemical carcinogenesis - receptor activation
Prostate cancer
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
vRNP Assembly
Regulation of actin dynamics for phagocytic cup formation
eNOS activation
Regulation of PLK1 Activity at G2/M Transition
Scavenging by Class F Receptors
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
Uptake and function of diphtheria toxin
Anchoring of the basal body to the plasma membrane
Constitutive Signaling by EGFRvIII
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Downregulation of ERBB2 signaling
ESR-mediated signaling
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
20562527
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
20562527
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
20562527
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 21907973 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Acquired ichthyosis Associate 36303457
Acute Kidney Injury Associate 35588657, 37058032
Acute Lung Injury Associate 34199261
Adenocarcinoma Associate 27491302, 35709760, 36982267
Adenocarcinoma of Lung Associate 26517240, 27356570, 31370342, 33370472, 33802597, 37000102, 37762133, 38164943
Adenosarcoma Associate 33370472
Adrenocortical Carcinoma Associate 31561992
Aicardi Syndrome Associate 24850175
Alcoholism Associate 22898980
Alopecia Areata Associate 29323127