Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3312
Gene name Gene Name - the full gene name approved by the HGNC.
Heat shock protein family A (Hsp70) member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HSPA8
Synonyms (NCBI Gene) Gene synonyms aliases
HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q24.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT052021 hsa-let-7b-5p CLASH 23622248
MIRT052021 hsa-let-7b-5p CLASH 23622248
MIRT051117 hsa-miR-16-5p CLASH 23622248
MIRT051117 hsa-miR-16-5p CLASH 23622248
MIRT050343 hsa-miR-25-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
KLF4 Activation 18379898
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000398 Process MRNA splicing, via spliceosome TAS
GO:0000974 Component Prp19 complex IDA 20176811
GO:0001664 Function G protein-coupled receptor binding IPI 12150907
GO:0001786 Function Phosphatidylserine binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600816 5241 ENSG00000109971
Protein
UniProt ID P11142
Protein name Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Protein function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfold
PDB 3AGY , 3AGZ , 3ESK , 3FZF , 3FZH , 3FZK , 3FZL , 3FZM , 3LDQ , 3M3Z , 4H5N , 4H5R , 4H5T , 4H5V , 4H5W , 4HWI , 4KBQ , 5AQF , 5AQG , 5AQH , 5AQI , 5AQJ , 5AQK , 5AQL , 5AQM , 5AQN , 5AQO , 5AQP , 5AQQ , 5AQR , 5AQS , 5AQT , 5AQU , 5AQV , 6B1I , 6B1M , 6B1N , 6ZYJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 6 612 Hsp70 protein Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11276205}.
Sequence
Sequence length 646
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Spliceosome
MAPK signaling pathway
Protein processing in endoplasmic reticulum
Endocytosis
Longevity regulating pathway - multiple species
Antigen processing and presentation
Estrogen signaling pathway
Prion disease
Legionellosis
Toxoplasmosis
Measles
Lipid and atherosclerosis
  Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 15378696
Carcinoma Squamous cell carcinoma, Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 15274141, 15378696
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
15378696
Spinocerebellar ataxia SPINOCEREBELLAR ATAXIA 17 rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926
View all (203 more)
24413982
Unknown
Disease term Disease name Evidence References Source
Coronary syndrome Acute Coronary Syndrome 21751358 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 34884786
Acute Kidney Injury Associate 30678657
Adenocarcinoma Associate 34128342
Adenocarcinoma of Lung Associate 34684727
Alzheimer Disease Inhibit 36246562
Amyotrophic Lateral Sclerosis Associate 32687490
Arthritis Rheumatoid Stimulate 10225814, 14730603
Arthritis Rheumatoid Associate 28603283
Atherosclerosis Associate 35886046
Atrial Fibrillation Associate 30678657