Gene Gene information from NCBI Gene database.
Entrez ID 3312
Gene name Heat shock protein family A (Hsp70) member 8
Gene symbol HSPA8
Synonyms (NCBI Gene)
HEL-33HEL-S-72pHSC54HSC70HSC71HSP71HSP73HSPA10LAP-1LAP1NIP71
Chromosome 11
Chromosome location 11q24.1
Summary This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a
miRNA miRNA information provided by mirtarbase database.
1331
miRTarBase ID miRNA Experiments Reference
MIRT052021 hsa-let-7b-5p CLASH 23622248
MIRT052021 hsa-let-7b-5p CLASH 23622248
MIRT051117 hsa-miR-16-5p CLASH 23622248
MIRT051117 hsa-miR-16-5p CLASH 23622248
MIRT050343 hsa-miR-25-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
KLF4 Activation 18379898
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
117
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000398 Process MRNA splicing, via spliceosome NAS 23742842
GO:0000974 Component Prp19 complex IDA 20176811
GO:0000974 Component Prp19 complex IPI 20176811
GO:0001664 Function G protein-coupled receptor binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600816 5241 ENSG00000109971
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11142
Protein name Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Protein function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfold
PDB 3AGY , 3AGZ , 3ESK , 3FZF , 3FZH , 3FZK , 3FZL , 3FZM , 3LDQ , 3M3Z , 4H5N , 4H5R , 4H5T , 4H5V , 4H5W , 4HWI , 4KBQ , 5AQF , 5AQG , 5AQH , 5AQI , 5AQJ , 5AQK , 5AQL , 5AQM , 5AQN , 5AQO , 5AQP , 5AQQ , 5AQR , 5AQS , 5AQT , 5AQU , 5AQV , 6B1I , 6B1M , 6B1N , 6ZYJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 6 612 Hsp70 protein Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11276205}.
Sequence
Sequence length 646
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Spliceosome
MAPK signaling pathway
Protein processing in endoplasmic reticulum
Endocytosis
Longevity regulating pathway - multiple species
Antigen processing and presentation
Estrogen signaling pathway
Prion disease
Legionellosis
Toxoplasmosis
Measles
Lipid and atherosclerosis
  Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Uncertain significance rs569651128 RCV005932421
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 34884786
Acute Kidney Injury Associate 30678657
Adenocarcinoma Associate 34128342
Adenocarcinoma of Lung Associate 34684727
Alzheimer Disease Inhibit 36246562
Amyotrophic Lateral Sclerosis Associate 32687490
Arthritis Rheumatoid Stimulate 10225814, 14730603
Arthritis Rheumatoid Associate 28603283
Atherosclerosis Associate 35886046
Atrial Fibrillation Associate 30678657