Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3309
Gene name Gene Name - the full gene name approved by the HGNC.
Heat shock protein family A (Hsp70) member 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HSPA5
Synonyms (NCBI Gene) Gene synonyms aliases
BIP, GRP78, HEL-S-89n
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q33.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018562 hsa-miR-335-5p Microarray 18185580
MIRT023362 hsa-miR-122-5p Other 21750653
MIRT031900 hsa-miR-16-5p Proteomics 18668040
MIRT038848 hsa-miR-93-3p CLASH 23622248
MIRT053102 hsa-miR-199a-5p Luciferase reporter assay, qRT-PCR, Western blot 23598416
Transcription factors
Transcription factor Regulation Reference
ATF4 Repression 16205636
ATF6 Unknown 12713871
BRCA1 Repression 18776923
E2F1 Repression 18840615
GTF2I Activation 19097122;21503958
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005509 Function Calcium ion binding TAS 16130169
GO:0005515 Function Protein binding IPI 11907036, 12356756, 12577067, 12840015, 18064632, 18264092, 18502753, 18923428, 18923430, 19632185, 20335166, 20467437, 20477988, 20936779, 22613557, 22689054, 22735594, 22796945, 23220234, 23349634, 23769672, 23990668, 24189400, 24473200, 25601083, 26496610, 26551274, 27238082, 285
GO:0005524 Function ATP binding IDA 26655470
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
138120 5238 ENSG00000044574
Protein
UniProt ID P11021
Protein name Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin h
Protein function Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and
PDB 3IUC , 3LDL , 3LDN , 3LDO , 3LDP , 5E84 , 5E85 , 5E86 , 5EVZ , 5EX5 , 5EXW , 5EY4 , 5F0X , 5F1X , 5F2R , 6ASY , 6CZ1 , 6DFM , 6DFO , 6DO2 , 6DWS , 6ZMD , 7N1R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 30 636 Hsp70 protein Family
Sequence
Sequence length 654
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Protein export
Protein processing in endoplasmic reticulum
Antigen processing and presentation
Thyroid hormone synthesis
Parkinson disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Lipid and atherosclerosis
  Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Anxiety Disorder Anxiety N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Stimulate 35840040
Abortion Habitual Stimulate 25935494
Acidosis Stimulate 24964091
Acute On Chronic Liver Failure Associate 26173605
Adenocarcinoma Associate 18331622, 34789798
Adenocarcinoma Of Esophagus Associate 18331622
Adenoma Associate 26066753
Albuminuria Inhibit 34414940
Alcoholism Associate 36577732
Allan Herndon Dudley syndrome Associate 21928251