Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3306
Gene name Gene Name - the full gene name approved by the HGNC.	Heat shock protein family A (Hsp70) member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HSPA2
Synonyms (NCBI Gene) Gene synonyms aliases	HSP70-2, HSP70-3
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q23.3

Show/Hide all(94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024730	hsa-miR-215-5p	Microarray	19074876
MIRT026895	hsa-miR-192-5p	Microarray	19074876
MIRT036912	hsa-miR-877-3p	CLASH	23622248
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT632863	hsa-miR-3929	HITS-CLIP	23824327
MIRT632862	hsa-miR-4419b	HITS-CLIP	23824327
MIRT632861	hsa-miR-4478	HITS-CLIP	23824327
MIRT632860	hsa-miR-5690	HITS-CLIP	23824327
MIRT632859	hsa-miR-8088	HITS-CLIP	23824327
MIRT632858	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632857	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT632856	hsa-miR-7977	HITS-CLIP	23824327
MIRT632855	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	20371350
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	22012620
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT632863	hsa-miR-3929	HITS-CLIP	23824327
MIRT632862	hsa-miR-4419b	HITS-CLIP	23824327
MIRT632861	hsa-miR-4478	HITS-CLIP	23824327
MIRT632860	hsa-miR-5690	HITS-CLIP	23824327
MIRT632859	hsa-miR-8088	HITS-CLIP	23824327
MIRT632858	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632857	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT632856	hsa-miR-7977	HITS-CLIP	23824327
MIRT632855	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610010	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT610009	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT610008	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT610007	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT610006	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	20371350
MIRT527555	hsa-miR-5003-5p	PAR-CLIP	22012620
MIRT1056135	hsa-miR-3143	CLIP-seq
MIRT1056136	hsa-miR-3144-3p	CLIP-seq
MIRT1056137	hsa-miR-33a	CLIP-seq
MIRT1056138	hsa-miR-33b	CLIP-seq
MIRT1056139	hsa-miR-450b-5p	CLIP-seq
MIRT1056140	hsa-miR-4729	CLIP-seq
MIRT1056141	hsa-miR-491-3p	CLIP-seq
MIRT1056142	hsa-miR-518a-5p	CLIP-seq
MIRT1056143	hsa-miR-527	CLIP-seq
MIRT1056144	hsa-miR-548an	CLIP-seq
MIRT1056145	hsa-miR-548l	CLIP-seq
MIRT1056146	hsa-miR-548n	CLIP-seq
MIRT1056147	hsa-miR-583	CLIP-seq
MIRT1056148	hsa-miR-586	CLIP-seq
MIRT1056149	hsa-miR-875-5p	CLIP-seq
MIRT2682473	hsa-miR-3613-3p	CLIP-seq
MIRT2682474	hsa-miR-4457	CLIP-seq
MIRT2682475	hsa-miR-495	CLIP-seq
MIRT2682476	hsa-miR-607	CLIP-seq

Show/Hide all(53)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000795	Component	Synaptonemal complex	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 16713569, 25036637, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	21231916
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006457	Process	Protein folding	IBA
GO:0006986	Process	Response to unfolded protein	IEA
GO:0006986	Process	Response to unfolded protein	TAS	7829106
GO:0007140	Process	Male meiotic nuclear division	IEA
GO:0007140	Process	Male meiotic nuclear division	TAS	8622925
GO:0007141	Process	Male meiosis I	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007286	Process	Spermatid development	IEA
GO:0007286	Process	Spermatid development	TAS	8622925
GO:0009408	Process	Response to heat	ISS
GO:0009409	Process	Response to cold	ISS
GO:0009986	Component	Cell surface	IEA
GO:0010971	Process	Positive regulation of G2/M transition of mitotic cell cycle	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0019899	Function	Enzyme binding	IEA
GO:0019899	Function	Enzyme binding	IPI	23921388
GO:0030154	Process	Cell differentiation	IEA
GO:0031072	Function	Heat shock protein binding	IBA
GO:0036128	Component	CatSper complex	IEA
GO:0036128	Component	CatSper complex	ISS
GO:0042026	Process	Protein refolding	IBA
GO:0042026	Process	Protein refolding	IDA	21231916
GO:0042026	Process	Protein refolding	IEA
GO:0044183	Function	Protein folding chaperone	IBA
GO:0048156	Function	Tau protein binding	IEA
GO:0051082	Function	Unfolded protein binding	IDA	21231916
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051082	Function	Unfolded protein binding	TAS	3037489
GO:0051087	Function	Protein-folding chaperone binding	IEA
GO:0051861	Function	Glycolipid binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070194	Process	Synaptonemal complex disassembly	IEA
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0072687	Component	Meiotic spindle	IEA
GO:0072687	Component	Meiotic spindle	ISS
GO:0090084	Process	Negative regulation of inclusion body assembly	IDA	21231916
GO:0140662	Function	ATP-dependent protein folding chaperone	IEA

MIM	HGNC	e!Ensembl
140560	5235	ENSG00000126803

Protein

UniProt ID

P54652

Protein name

Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2)

Protein function

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation

PDB

3I33 , 4FSV , 5FPD , 5FPE , 5FPM , 5FPN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00012	HSP70	7 → 615	Hsp70 protein	Family

Sequence

MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQV
AMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEI
SSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAA
AIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRM
VSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSI
TRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGK
ELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRN
TTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVT
FDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVA
AKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQK
ELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD

Sequence length

639

Interactions

View interactions

	KEGG		Reactome
	Antigen processing and presentation Lipid and atherosclerosis		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Eczema	Eczema	N/A	N/A	GWAS

Show/Hide Text Mining Associations (49)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acute Disease	Associate	16333988
Agranulocytosis	Associate	7579351
Alzheimer Disease	Associate	30137212, 34480088
Alzheimer Disease	Stimulate	36246562
Arrest of spermatogenesis	Inhibit	10856471
Arrest of spermatogenesis	Associate	20075417, 31006710
Asthenozoospermia	Associate	27209630
Atrophy	Associate	19661373
Azoospermia	Associate	25439847
Breast Neoplasms	Associate	26576432, 31101846
Carcinoma Hepatocellular	Associate	25117073
Carcinoma Non Small Cell Lung	Associate	31591429
Carcinoma Pancreatic Ductal	Associate	25890028
Carcinoma Renal Cell	Associate	25213699
Coronary Artery Disease	Associate	22834788
Diabetes Mellitus Type 2	Associate	28246355
Diabetic Nephropathies	Associate	28246355
Esophageal Squamous Cell Carcinoma	Stimulate	23777267
Fabry Disease	Associate	31378672
Fatigue Syndrome Chronic	Associate	24054763
Gastritis Atrophic	Associate	19661373
Graves Disease	Associate	26782485
Hearing Loss Noise Induced	Associate	17009596
Infertility Male	Associate	11730740, 23209833
Inflammation	Associate	19661373
Intestinal Fistula	Associate	25253958
Kidney Diseases	Associate	28246355
Lymphatic Metastasis	Stimulate	23777267, 25890028
Male Infertility with Large Headed Multiflagellar Polyploid Spermatozoa	Associate	20075417
Metaplasia	Associate	19661373
Mood Disorders	Associate	16636682
Neoplasm Metastasis	Associate	25213699, 25890028
Neoplasms	Associate	15741319, 22797398, 23777267, 25117073, 25213699, 25798051, 25890028, 31591429, 36959387
Neuroendocrine Tumors	Associate	33391466
Obesity	Associate	26728972
Oligospermia	Inhibit	17007855
Pancreatic Neoplasms	Associate	22797398, 25890028
Pancreatitis	Associate	22797398
Pancreatitis Chronic	Associate	22797398
Pulmonary edema of mountaineers	Stimulate	16333988
Sarcopenia	Associate	33743591
Seminoma	Associate	31006710
Sertoli Cell Only Syndrome	Associate	10856471
Spermatogenic Failure Nonobstructive Y Linked	Associate	20075417, 25308252
Spondylarthropathies	Stimulate	11779758
Stomach Diseases	Associate	19661373
Triple Negative Breast Neoplasms	Associate	37306188
Varicocele	Inhibit	17007855
Varicocele	Associate	26732106

HSPA2 (heat shock protein family A (Hsp70) member 2)