Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3305
Gene name Gene Name - the full gene name approved by the HGNC.	Heat shock protein family A (Hsp70) member 1 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HSPA1L
Synonyms (NCBI Gene) Gene synonyms aliases	HSP70-1L, HSP70-HOM, HSP70T, hum70t
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is

Show/Hide all(22)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016961	hsa-miR-335-5p	Microarray	18185580
MIRT016961	hsa-miR-335-5p	Microarray	18185580
MIRT028894	hsa-miR-26b-5p	Microarray	19088304
MIRT028894	hsa-miR-26b-5p	Microarray	19088304
MIRT041506	hsa-miR-193b-3p	CLASH	23622248
MIRT2012888	hsa-miR-1237	CLIP-seq
MIRT2012889	hsa-miR-1248	CLIP-seq
MIRT2012890	hsa-miR-128	CLIP-seq
MIRT2012891	hsa-miR-27a	CLIP-seq
MIRT2012892	hsa-miR-27b	CLIP-seq
MIRT2012893	hsa-miR-3919	CLIP-seq
MIRT2012894	hsa-miR-3925-3p	CLIP-seq
MIRT2012895	hsa-miR-3925-5p	CLIP-seq
MIRT2012896	hsa-miR-4643	CLIP-seq
MIRT2012897	hsa-miR-4756-3p	CLIP-seq
MIRT2012898	hsa-miR-513a-5p	CLIP-seq
MIRT2012899	hsa-miR-515-5p	CLIP-seq
MIRT2012900	hsa-miR-766	CLIP-seq
MIRT2012893	hsa-miR-3919	CLIP-seq
MIRT2012895	hsa-miR-3925-5p	CLIP-seq
MIRT2012896	hsa-miR-4643	CLIP-seq
MIRT2012897	hsa-miR-4756-3p	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002199	Component	Zona pellucida receptor complex	IEA
GO:0005515	Function	Protein binding	IPI	17184779, 25036637, 25241761, 25609649, 32296183
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	21231916
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006986	Process	Response to unfolded protein	TAS	9685725
GO:0007339	Process	Binding of sperm to zona pellucida	IEA
GO:0008180	Component	COP9 signalosome	IBA	21873635
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0016192	Process	Vesicle-mediated transport	IBA	21873635
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0031072	Function	Heat shock protein binding	IBA	21873635
GO:0031072	Function	Heat shock protein binding	IPI	17182002
GO:0031625	Function	Ubiquitin protein ligase binding	IBA	21873635
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	24270810
GO:0034620	Process	Cellular response to unfolded protein	IBA	21873635
GO:0042026	Process	Protein refolding	IBA	21873635
GO:0042026	Process	Protein refolding	IDA	21231916
GO:0044183	Function	Protein folding chaperone	IBA	21873635
GO:0044297	Component	Cell body	IEA
GO:0051082	Function	Unfolded protein binding	IBA	21873635
GO:0051082	Function	Unfolded protein binding	IDA	21231916
GO:0051085	Process	Chaperone cofactor-dependent protein refolding	IBA	21873635
GO:0051787	Function	Misfolded protein binding	IBA	21873635
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1900034	Process	Regulation of cellular response to heat	TAS
GO:1903955	Process	Positive regulation of protein targeting to mitochondrion	IMP	24270810

MIM	HGNC	e!Ensembl
140559	5234	ENSG00000204390

Protein

UniProt ID

P34931

Protein name

Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L)

Protein function

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation

PDB

3GDQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00012	HSP70	8 → 614	Hsp70 protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in spermatids. {ECO:0000269|PubMed:9685725}.

Sequence

MATAKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQ
VAMNPQNTVFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEE
ISSMVLTKLKETAEAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTA
AAIAYGLDKGGQGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLV
SHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSIT
RARFEELCADLFRGTLEPVEKALRDAKMDKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRD
LNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLDVAPLSLGLETAGGVMTALIKRNS
TIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFDLTGIPPAPRGVPQIEVTF
DIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEKYKAEDEVQREKIAA
KNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEKDEFDHKRKE
LEQMCNPIITKLYQGGCTGPACGTGYVPGRPATGPTIEEVD

Sequence length

641

Interactions

View interactions

	KEGG		Reactome
	Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum Endocytosis Longevity regulating pathway - multiple species Antigen processing and presentation Estrogen signaling pathway Prion disease Legionellosis Toxoplasmosis Measles Lipid and atherosclerosis		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	17632545
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	20598377
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	19503088, 17804836, 21156761
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	19439993, 18299791, 15963589, 23893339

Show/Hide Unknown Diseases (4)

Disease term	Disease name	References	Source
Unknown
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		ClinVar
Crohn disease	Regional enteritis	28126021	ClinVar
Mental depression	Major depression, single episode, Unipolar Depression, Major Depressive Disorder	17428599	ClinVar
Alzheimer disease	Alzheimer disease		GWAS

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text Mining
Age Related Hearing Impairment 1	Associate	33926545
Bipolar Disorder	Associate	28291257
Carcinoma Non Small Cell Lung	Associate	32971893
Colorectal Neoplasms	Associate	30755640, 33600380
COVID 19	Associate	34823125
Cytomegalovirus Infections	Associate	33446692
Dental Caries	Associate	27567034
Diabetes Mellitus Type 2	Associate	28246355
Diabetic Nephropathies	Associate	28246355
Drug Hypersensitivity	Associate	15024131
Essential Hypertension	Associate	19085089
Glioma	Associate	39454876
Hearing Loss Noise Induced	Associate	17009596, 18813331, 28182740
Idiopathic Pulmonary Fibrosis	Associate	26496868
Inflammatory Bowel Diseases	Associate	28126021
Kidney Diseases	Associate	28246355
Lupus Erythematosus Systemic	Associate	20498198
Macular Degeneration	Associate	30946360
Muscle Hypotonia	Associate	26453269
Nasopharyngeal Carcinoma	Associate	26198046
Neoplasms	Associate	25798051, 32971893
Parkinson Disease	Associate	39454876
Periapical Diseases	Associate	27567034
Periapical Periodontitis	Associate	27567034
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	20012387
Prostatitis	Associate	36071874
Pulmonary edema of mountaineers	Associate	16333988
Spinal Cord Injuries	Associate	37063890
Spondylarthropathies	Associate	11779758
Urinary Bladder Neoplasms	Associate	34905506

HSPA1L (heat shock protein family A (Hsp70) member 1 like)