Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3304
Gene name Gene Name - the full gene name approved by the HGNC.
Heat shock protein family A (Hsp70) member 1B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HSPA1B
Synonyms (NCBI Gene) Gene synonyms aliases
HSP70-1, HSP70-1B, HSP70-2, HSP70.1, HSP70.2, HSP72, HSPA1, HSX70
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly tr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016862 hsa-miR-335-5p Microarray 18185580
MIRT025314 hsa-miR-34a-5p Proteomics 21566225
MIRT001457 hsa-miR-16-5p Proteomics 18668040
MIRT052128 hsa-let-7b-5p CLASH 23622248
MIRT001457 hsa-miR-16-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
HSF1 Unknown 20692357
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001618 Function Virus receptor activity IEA
GO:0001664 Function G protein-coupled receptor binding IDA 12150907
GO:0001664 Function G protein-coupled receptor binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603012 5233 ENSG00000204388
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Spliceosome
MAPK signaling pathway
Protein processing in endoplasmic reticulum
Endocytosis
Longevity regulating pathway - multiple species
Antigen processing and presentation
Estrogen signaling pathway
Prion disease
Legionellosis
Toxoplasmosis
Measles
Lipid and atherosclerosis
  Viral RNP Complexes in the Host Cell Nucleus
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
chronic obstructive pulmonary disease Chronic obstructive pulmonary disease N/A N/A ClinVar
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Age Related Hearing Impairment 1 Associate 33926545
Altitude Sickness Associate 32478477
Alzheimer Disease Inhibit 15544168
Arthritis Rheumatoid Associate 32358783
Asthma Associate 36553658
Atherosclerosis Associate 22328194
Breast Neoplasms Associate 37684436
Carcinogenesis Associate 39456901
Carcinoma Associate 35265720
Carcinoma Hepatocellular Associate 18344806, 29391759, 35243668