Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	330
Gene name Gene Name - the full gene name approved by the HGNC.	Baculoviral IAP repeat containing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BIRC3
Synonyms (NCBI Gene) Gene synonyms aliases	AIP1, API2, CIAP2, HAIP1, HIAP1, IAP-1, MALT2, MIHC, RNF49, c-IAP2
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits ap

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000071	hsa-miR-34a-5p	Microarray, Northern blot	17540599
MIRT019771	hsa-miR-375	Microarray	20215506
MIRT027437	hsa-miR-98-5p	Microarray	19088304
MIRT821549	hsa-miR-1182	CLIP-seq
MIRT821550	hsa-miR-1207-5p	CLIP-seq
MIRT821551	hsa-miR-3714	CLIP-seq
MIRT821552	hsa-miR-4264	CLIP-seq
MIRT821553	hsa-miR-4477a	CLIP-seq
MIRT821554	hsa-miR-4484	CLIP-seq
MIRT821555	hsa-miR-4728-3p	CLIP-seq
MIRT821556	hsa-miR-4763-3p	CLIP-seq
MIRT821557	hsa-miR-4775	CLIP-seq
MIRT821558	hsa-miR-4797-3p	CLIP-seq
MIRT821559	hsa-miR-513a-3p	CLIP-seq
MIRT821560	hsa-miR-548an	CLIP-seq
MIRT821561	hsa-miR-548n	CLIP-seq
MIRT821562	hsa-miR-548t	CLIP-seq
MIRT821563	hsa-miR-561	CLIP-seq
MIRT821564	hsa-miR-590-3p	CLIP-seq
MIRT821565	hsa-miR-651	CLIP-seq
MIRT821566	hsa-miR-940	CLIP-seq
MIRT821567	hsa-miR-1297	CLIP-seq
MIRT821568	hsa-miR-26a	CLIP-seq
MIRT821569	hsa-miR-26b	CLIP-seq
MIRT821570	hsa-miR-3152-5p	CLIP-seq
MIRT821571	hsa-miR-3199	CLIP-seq
MIRT821572	hsa-miR-4269	CLIP-seq
MIRT821573	hsa-miR-4437	CLIP-seq
MIRT821574	hsa-miR-4438	CLIP-seq
MIRT821575	hsa-miR-4465	CLIP-seq
MIRT821576	hsa-miR-4753-3p	CLIP-seq
MIRT821577	hsa-miR-5095	CLIP-seq
MIRT821578	hsa-miR-661	CLIP-seq
MIRT821571	hsa-miR-3199	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
DEK	Unknown	16829531
HDAC1	Activation	17000776
NFKB1	Activation	10733571;11297551;11880364;12010810;19343319
NFKB1	Repression	15231833;15723831;18566231
NFKB1	Unknown	10823821;15050749;17000776;17673602
REL	Activation	11880364
RELA	Activation	10733571;11297551;11880364;12010810;19343319
RELA	Repression	15231833;15723831;18566231
RELA	Unknown	10823821;15050749;17000776;17673602

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	EXP	10797013
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	16395405, 21931591
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	TAS
GO:0005515	Function	Protein binding	IPI	11907583, 16123224, 16282325, 16395405, 19690564, 20562859, 21849505, 21931591, 21988832, 22902369, 23524849, 25241761, 25260751, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15665297, 16123224
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15665297, 16123224
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	8548810
GO:0007249	Process	Canonical NF-kappaB signal transduction	IEA
GO:0007249	Process	Canonical NF-kappaB signal transduction	TAS
GO:0007283	Process	Spermatogenesis	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016740	Function	Transferase activity	EXP	19008929
GO:0016740	Function	Transferase activity	IEA
GO:0031398	Process	Positive regulation of protein ubiquitination	IBA
GO:0031398	Process	Positive regulation of protein ubiquitination	IDA	21931591
GO:0031398	Process	Positive regulation of protein ubiquitination	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IEA
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0034121	Process	Regulation of toll-like receptor signaling pathway	IEA
GO:0034121	Process	Regulation of toll-like receptor signaling pathway	TAS	20888210
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	IEA
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	TAS	20651737
GO:0039535	Process	Regulation of RIG-I signaling pathway	IEA
GO:0039535	Process	Regulation of RIG-I signaling pathway	TAS	20888210
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	IMP	21737330
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	8552191
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	TAS	20651737
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045088	Process	Regulation of innate immune response	TAS	21447281
GO:0046872	Function	Metal ion binding	IEA
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	TAS	21447281
GO:0051726	Process	Regulation of cell cycle	IBA
GO:0060544	Process	Regulation of necroptotic process	IEA
GO:0060544	Process	Regulation of necroptotic process	IMP	21737330
GO:0060544	Process	Regulation of necroptotic process	TAS
GO:0060546	Process	Negative regulation of necroptotic process	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070424	Process	Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	IEA
GO:0070424	Process	Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	TAS	20888210

MIM	HGNC	e!Ensembl
601721	591	ENSG00000023445

Protein

UniProt ID

Q13489

Protein name

Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin tran

Protein function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin

PDB

2UVL , 3EB5 , 3EB6 , 3M0A , 3M0D , 7NK0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00653	BIR	32 → 97	Inhibitor of Apoptosis domain	Domain
PF00653	BIR	172 → 236	Inhibitor of Apoptosis domain	Domain
PF00653	BIR	258 → 323	Inhibitor of Apoptosis domain	Domain
PF00619	CARD	444 → 528	Caspase recruitment domain	Domain
PF13920	zf-C3HC4_3	553 → 598		Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

Sequence

MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGV
NDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS
THSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP
LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQ
DTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR
CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS
IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDL
LNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHD
VIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVS
DLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVR
TFLS

Sequence length

604

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance NF-kappa B signaling pathway Ubiquitin mediated proteolysis Apoptosis Apoptosis - multiple species Necroptosis Hippo signaling pathway Focal adhesion NOD-like receptor signaling pathway TNF signaling pathway Salmonella infection Toxoplasmosis Herpes simplex virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Small cell lung cancer		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1

BIRC3 (baculoviral IAP repeat containing 3)