Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	33
Gene name Gene Name - the full gene name approved by the HGNC.	Acyl-CoA dehydrogenase long chain
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ACADL
Synonyms (NCBI Gene) Gene synonyms aliases	ACAD4, LCAD
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q34
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022288	hsa-miR-124-3p	Microarray	18668037
MIRT715136	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT715135	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT715134	hsa-miR-3183	HITS-CLIP	19536157
MIRT715133	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT715132	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT715131	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT715130	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT715129	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT715128	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT715127	hsa-miR-4279	HITS-CLIP	19536157
MIRT715126	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT715125	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT715124	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT462192	hsa-miR-34b-3p	PAR-CLIP	23592263
MIRT462191	hsa-miR-1228-3p	PAR-CLIP	23592263
MIRT462190	hsa-miR-383-3p	PAR-CLIP	23592263
MIRT462189	hsa-miR-6089	PAR-CLIP	23592263
MIRT462188	hsa-miR-6134	PAR-CLIP	23592263
MIRT462186	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT462187	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT462185	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT462184	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT462183	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT462182	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT462181	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT462180	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT462179	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT462178	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT462177	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT462176	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT462175	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT462174	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT462173	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT462172	hsa-miR-3689c	PAR-CLIP	23592263
MIRT462170	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT462171	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT462169	hsa-miR-450a-1-3p	PAR-CLIP	23592263
MIRT462168	hsa-miR-3122	PAR-CLIP	23592263
MIRT462167	hsa-miR-3913-5p	PAR-CLIP	23592263
MIRT462166	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT462164	hsa-miR-6513-5p	PAR-CLIP	23592263
MIRT715136	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT715135	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT715134	hsa-miR-3183	HITS-CLIP	19536157
MIRT715133	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT715132	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT715131	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT715130	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT715129	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT715128	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT715127	hsa-miR-4279	HITS-CLIP	19536157
MIRT715126	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT715125	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT715124	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT462192	hsa-miR-34b-3p	PAR-CLIP	23592263
MIRT462191	hsa-miR-1228-3p	PAR-CLIP	23592263
MIRT462190	hsa-miR-383-3p	PAR-CLIP	23592263
MIRT462189	hsa-miR-6089	PAR-CLIP	23592263
MIRT462188	hsa-miR-6134	PAR-CLIP	23592263
MIRT462186	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT462187	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT462185	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT462184	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT462183	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT462182	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT462181	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT462180	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT462179	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT462178	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT462177	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT462176	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT462175	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT462174	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT462173	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT462172	hsa-miR-3689c	PAR-CLIP	23592263
MIRT462170	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT462171	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT462169	hsa-miR-450a-1-3p	PAR-CLIP	23592263
MIRT462168	hsa-miR-3122	PAR-CLIP	23592263
MIRT462167	hsa-miR-3913-5p	PAR-CLIP	23592263
MIRT462166	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT462164	hsa-miR-6513-5p	PAR-CLIP	23592263
MIRT761440	hsa-miR-323-3p	CLIP-seq
MIRT761441	hsa-miR-3682-5p	CLIP-seq
MIRT761442	hsa-miR-4684-3p	CLIP-seq
MIRT761443	hsa-miR-4699-3p	CLIP-seq
MIRT761444	hsa-miR-4724-3p	CLIP-seq
MIRT761445	hsa-miR-518a-5p	CLIP-seq
MIRT761446	hsa-miR-527	CLIP-seq
MIRT1920213	hsa-miR-4289	CLIP-seq
MIRT1920213	hsa-miR-4289	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
PPARA	Unknown	20110263

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001659	Process	Temperature homeostasis	ISS
GO:0003995	Function	Acyl-CoA dehydrogenase activity	IEA
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	IBA
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	IDA	1945557
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	IEA
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	ISS
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0016042	Process	Lipid catabolic process	ISS
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0019254	Process	Carnitine metabolic process, CoA-linked	IBA
GO:0019254	Process	Carnitine metabolic process, CoA-linked	ISS
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	IEA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISS
GO:0042413	Process	Carnitine catabolic process	ISS
GO:0042758	Process	Long-chain fatty acid catabolic process	IBA
GO:0042758	Process	Long-chain fatty acid catabolic process	IEA
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0045717	Process	Negative regulation of fatty acid biosynthetic process	ISS
GO:0046322	Process	Negative regulation of fatty acid oxidation	ISS
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0090181	Process	Regulation of cholesterol metabolic process	ISS
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	9802886

MIM	HGNC	e!Ensembl
609576	88	ENSG00000115361

Protein

UniProt ID

P28330

Protein name

Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)

Protein function

Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of

PDB

8W0T , 8W0U , 8W0Z

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02771	Acyl-CoA_dh_N	54 → 165	Acyl-CoA dehydrogenase, N-terminal domain	Domain
PF02770	Acyl-CoA_dh_M	169 → 266	Acyl-CoA dehydrogenase, middle domain	Domain
PF00441	Acyl-CoA_dh_1	278 → 427	Acyl-CoA dehydrogenase, C-terminal domain	Domain

Sequence

MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIF
RKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIV
WEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSD
LQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMK
GFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRL
DSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE
LIAREIVFDK

Sequence length

430

Interactions

View interactions

	KEGG		Reactome
	Fatty acid degradation Metabolic pathways Fatty acid metabolism PPAR signaling pathway		Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Acyl CoA Dehydrogenase Deficiency	very long chain acyl-coa dehydrogenase deficiency, long chain acyl-CoA dehydrogenase deficiency	N/A	N/A	ClinVar, GenCC

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Hepatocellular	Inhibit	37151879
Colorectal Neoplasms	Associate	32953885
Diabetes Mellitus Type 2	Inhibit	24403596
Lung Neoplasms	Associate	34970420
Meningioma	Associate	37014425
Mitochondrial Diseases	Associate	34970420
Neoplasms	Inhibit	25242319, 32961983, 37151879, 38393683
Neoplasms	Associate	40050905
Osteoarthritis	Associate	38292759
Sjogren's Syndrome	Associate	29504848
Squamous Cell Carcinoma of Head and Neck	Associate	32961983
Stomach Neoplasms	Associate	26330360

ACADL (acyl-CoA dehydrogenase long chain)