Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3298
Gene name Gene Name - the full gene name approved by the HGNC.	Heat shock transcription factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HSF2
Synonyms (NCBI Gene) Gene synonyms aliases	HSF 2, HSTF 2
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q22.31
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions

Show/Hide all(107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005361	hsa-miR-18a-5p	Immunofluorescence, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	20724452
MIRT005361	hsa-miR-18a-5p	Immunofluorescence, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	20724452
MIRT029326	hsa-miR-26b-5p	Microarray	19088304
MIRT030504	hsa-miR-24-3p	Microarray	19748357
MIRT052530	hsa-let-7a-5p	CLASH	23622248
MIRT052530	hsa-let-7a-5p	CLASH	23622248
MIRT052083	hsa-let-7b-5p	CLASH	23622248
MIRT1055730	hsa-miR-2277-3p	CLIP-seq
MIRT1055731	hsa-miR-4282	CLIP-seq
MIRT1055732	hsa-miR-495	CLIP-seq
MIRT1055733	hsa-miR-569	CLIP-seq
MIRT1055734	hsa-miR-570	CLIP-seq
MIRT2245117	hsa-miR-1179	CLIP-seq
MIRT1055730	hsa-miR-2277-3p	CLIP-seq
MIRT2245118	hsa-miR-3919	CLIP-seq
MIRT2245119	hsa-miR-4266	CLIP-seq
MIRT2245120	hsa-miR-4468	CLIP-seq
MIRT2245121	hsa-miR-4653-3p	CLIP-seq
MIRT2245122	hsa-miR-651	CLIP-seq
MIRT2437653	hsa-miR-147	CLIP-seq
MIRT2437654	hsa-miR-2276	CLIP-seq
MIRT2437655	hsa-miR-3194-3p	CLIP-seq
MIRT2437656	hsa-miR-3591-3p	CLIP-seq
MIRT2437657	hsa-miR-3622a-3p	CLIP-seq
MIRT2437658	hsa-miR-3622b-3p	CLIP-seq
MIRT2437659	hsa-miR-3911	CLIP-seq
MIRT2437660	hsa-miR-4696	CLIP-seq
MIRT2437661	hsa-miR-4766-5p	CLIP-seq
MIRT2437662	hsa-miR-4772-3p	CLIP-seq
MIRT2437663	hsa-miR-574-5p	CLIP-seq
MIRT2437664	hsa-miR-644	CLIP-seq
MIRT2548034	hsa-miR-1270	CLIP-seq
MIRT2548035	hsa-miR-1273g	CLIP-seq
MIRT2548036	hsa-miR-144	CLIP-seq
MIRT2437653	hsa-miR-147	CLIP-seq
MIRT2548037	hsa-miR-18a	CLIP-seq
MIRT2548038	hsa-miR-18b	CLIP-seq
MIRT2437654	hsa-miR-2276	CLIP-seq
MIRT2548039	hsa-miR-3121-3p	CLIP-seq
MIRT2548040	hsa-miR-3140-3p	CLIP-seq
MIRT2548041	hsa-miR-3174	CLIP-seq
MIRT2437655	hsa-miR-3194-3p	CLIP-seq
MIRT2548042	hsa-miR-3200-5p	CLIP-seq
MIRT2548043	hsa-miR-330-3p	CLIP-seq
MIRT2437656	hsa-miR-3591-3p	CLIP-seq
MIRT2548044	hsa-miR-3606	CLIP-seq
MIRT2548045	hsa-miR-3613-3p	CLIP-seq
MIRT2437657	hsa-miR-3622a-3p	CLIP-seq
MIRT2437658	hsa-miR-3622b-3p	CLIP-seq
MIRT2548046	hsa-miR-3692	CLIP-seq
MIRT2437659	hsa-miR-3911	CLIP-seq
MIRT2548047	hsa-miR-3920	CLIP-seq
MIRT1055731	hsa-miR-4282	CLIP-seq
MIRT2548048	hsa-miR-4434	CLIP-seq
MIRT2548049	hsa-miR-4516	CLIP-seq
MIRT2548050	hsa-miR-4531	CLIP-seq
MIRT2437660	hsa-miR-4696	CLIP-seq
MIRT2548051	hsa-miR-4735-3p	CLIP-seq
MIRT2437661	hsa-miR-4766-5p	CLIP-seq
MIRT2437662	hsa-miR-4772-3p	CLIP-seq
MIRT1055732	hsa-miR-495	CLIP-seq
MIRT2548052	hsa-miR-520d-5p	CLIP-seq
MIRT2548053	hsa-miR-524-5p	CLIP-seq
MIRT2548054	hsa-miR-539	CLIP-seq
MIRT2548055	hsa-miR-548k	CLIP-seq
MIRT2548056	hsa-miR-548n	CLIP-seq
MIRT2548057	hsa-miR-548p	CLIP-seq
MIRT1055733	hsa-miR-569	CLIP-seq
MIRT1055734	hsa-miR-570	CLIP-seq
MIRT2437663	hsa-miR-574-5p	CLIP-seq
MIRT2548058	hsa-miR-620	CLIP-seq
MIRT2437664	hsa-miR-644	CLIP-seq
MIRT2548059	hsa-miR-921	CLIP-seq
MIRT2548035	hsa-miR-1273g	CLIP-seq
MIRT2548036	hsa-miR-144	CLIP-seq
MIRT2437653	hsa-miR-147	CLIP-seq
MIRT2548037	hsa-miR-18a	CLIP-seq
MIRT2548038	hsa-miR-18b	CLIP-seq
MIRT2437654	hsa-miR-2276	CLIP-seq
MIRT2548039	hsa-miR-3121-3p	CLIP-seq
MIRT2548040	hsa-miR-3140-3p	CLIP-seq
MIRT2548041	hsa-miR-3174	CLIP-seq
MIRT2437655	hsa-miR-3194-3p	CLIP-seq
MIRT2548042	hsa-miR-3200-5p	CLIP-seq
MIRT2548043	hsa-miR-330-3p	CLIP-seq
MIRT2437656	hsa-miR-3591-3p	CLIP-seq
MIRT2548044	hsa-miR-3606	CLIP-seq
MIRT2437657	hsa-miR-3622a-3p	CLIP-seq
MIRT2437658	hsa-miR-3622b-3p	CLIP-seq
MIRT2548046	hsa-miR-3692	CLIP-seq
MIRT2437659	hsa-miR-3911	CLIP-seq
MIRT2548047	hsa-miR-3920	CLIP-seq
MIRT1055731	hsa-miR-4282	CLIP-seq
MIRT2437660	hsa-miR-4696	CLIP-seq
MIRT2548051	hsa-miR-4735-3p	CLIP-seq
MIRT2437661	hsa-miR-4766-5p	CLIP-seq
MIRT2437662	hsa-miR-4772-3p	CLIP-seq
MIRT1055732	hsa-miR-495	CLIP-seq
MIRT2548052	hsa-miR-520d-5p	CLIP-seq
MIRT2548053	hsa-miR-524-5p	CLIP-seq
MIRT2548054	hsa-miR-539	CLIP-seq
MIRT2548057	hsa-miR-548p	CLIP-seq
MIRT1055733	hsa-miR-569	CLIP-seq
MIRT1055734	hsa-miR-570	CLIP-seq
MIRT2437663	hsa-miR-574-5p	CLIP-seq
MIRT2437664	hsa-miR-644	CLIP-seq
MIRT2548059	hsa-miR-921	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	10561509
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	8972228
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001162	Function	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA	10561509
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	10561509
GO:0003700	Function	DNA-binding transcription factor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25036637, 25416956, 25910212, 26727490, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007283	Process	Spermatogenesis	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	10561509
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
140581	5225	ENSG00000025156

Protein

UniProt ID

Q03933

Protein name

Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2)

Protein function

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

PDB

5D8K , 5D8L , 5HDK , 7DCI , 7DCU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00447	HSF_DNA-bind	10 → 110	HSF-type DNA-binding	Domain
PF06546	Vert_HS_TF	230 → 513	Vertebrate heat shock transcription factor	Family

Sequence

MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS
FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK
IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ
FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE
RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ
SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL
LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDYINNTKSENKGLETTK
NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP
IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS

Sequence length

536

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	30061737

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation		30061737	ClinVar
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining
Azoospermia	Associate	32756090
Brain Infarction	Associate	39736019
Carcinoma Hepatocellular	Associate	35606363, 37077914
Cerebral Infarction	Associate	39736019
Colitis Ulcerative	Associate	24533153
Esophageal Squamous Cell Carcinoma	Associate	28277193
Hypoxia	Stimulate	35606363
Leukemia Erythroblastic Acute	Associate	8114740
Mental Retardation X Linked Syndromic Christianson Type	Associate	34653234
Neoplasms	Associate	26727490
Pancreatic Neoplasms	Associate	34134622
Rubinstein Taybi Syndrome	Associate	36385105
Stomach Neoplasms	Associate	28058586
Thrombosis	Associate	40380263
Thyroid Neoplasms	Associate	26985959

HSF2 (heat shock transcription factor 2)