Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3274
Gene name	Histamine receptor H2
Gene symbol	HRH2
Synonyms (NCBI Gene)	H2RHH2R
Chromosome	5
Chromosome location	5q35.2
Summary	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled

Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016874	hsa-miR-335-5p	Microarray	18185580
MIRT409766	hsa-miR-3940-3p	PAR-CLIP	20371350
MIRT560290	hsa-miR-4476	PAR-CLIP	20371350
MIRT560289	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560287	hsa-miR-9500	PAR-CLIP	20371350
MIRT560288	hsa-miR-5697	PAR-CLIP	20371350
MIRT409768	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT560286	hsa-miR-3126-5p	PAR-CLIP	20371350
MIRT560285	hsa-miR-6875-5p	PAR-CLIP	20371350
MIRT560284	hsa-miR-4419a	PAR-CLIP	20371350
MIRT560283	hsa-miR-4510	PAR-CLIP	20371350
MIRT560282	hsa-miR-6127	PAR-CLIP	20371350
MIRT560281	hsa-miR-6129	PAR-CLIP	20371350
MIRT560280	hsa-miR-6130	PAR-CLIP	20371350
MIRT560279	hsa-miR-6133	PAR-CLIP	20371350
MIRT560278	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT409765	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT409767	hsa-miR-4710	PAR-CLIP	20371350
MIRT409769	hsa-miR-8065	PAR-CLIP	20371350
MIRT560277	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT409766	hsa-miR-3940-3p	PAR-CLIP	20371350
MIRT560290	hsa-miR-4476	PAR-CLIP	20371350
MIRT560289	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560287	hsa-miR-9500	PAR-CLIP	20371350
MIRT560288	hsa-miR-5697	PAR-CLIP	20371350
MIRT409768	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT560286	hsa-miR-3126-5p	PAR-CLIP	20371350
MIRT560285	hsa-miR-6875-5p	PAR-CLIP	20371350
MIRT560284	hsa-miR-4419a	PAR-CLIP	20371350
MIRT560283	hsa-miR-4510	PAR-CLIP	20371350
MIRT560282	hsa-miR-6127	PAR-CLIP	20371350
MIRT560281	hsa-miR-6129	PAR-CLIP	20371350
MIRT560280	hsa-miR-6130	PAR-CLIP	20371350
MIRT560279	hsa-miR-6133	PAR-CLIP	20371350
MIRT560278	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT409765	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT409767	hsa-miR-4710	PAR-CLIP	20371350
MIRT409769	hsa-miR-8065	PAR-CLIP	20371350
MIRT560277	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT1054681	hsa-miR-1206	CLIP-seq
MIRT1054682	hsa-miR-1273f	CLIP-seq
MIRT1054683	hsa-miR-2682	CLIP-seq
MIRT1054684	hsa-miR-3152-5p	CLIP-seq
MIRT1054685	hsa-miR-4328	CLIP-seq
MIRT1054686	hsa-miR-449c	CLIP-seq
MIRT1054687	hsa-miR-4774-3p	CLIP-seq
MIRT1054688	hsa-miR-940	CLIP-seq
MIRT2012432	hsa-miR-4269	CLIP-seq
MIRT2012433	hsa-miR-4502	CLIP-seq
MIRT2012434	hsa-miR-4514	CLIP-seq
MIRT2012435	hsa-miR-4692	CLIP-seq
MIRT2012436	hsa-miR-4742-5p	CLIP-seq
MIRT2012437	hsa-miR-526b	CLIP-seq
MIRT2012438	hsa-miR-578	CLIP-seq
MIRT2012439	hsa-miR-627	CLIP-seq
MIRT2012440	hsa-miR-924	CLIP-seq
MIRT2389167	hsa-miR-193a-5p	CLIP-seq
MIRT2389168	hsa-miR-2276	CLIP-seq
MIRT2389169	hsa-miR-3616-3p	CLIP-seq
MIRT2389170	hsa-miR-4527	CLIP-seq
MIRT2012436	hsa-miR-4742-5p	CLIP-seq
MIRT2389171	hsa-miR-4772-3p	CLIP-seq
MIRT2389172	hsa-miR-516b	CLIP-seq
MIRT2389173	hsa-miR-541	CLIP-seq
MIRT2389174	hsa-miR-654-5p	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001696	Process	Gastric acid secretion	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	IBA
GO:0004969	Function	Histamine receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	TAS	9725260
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1714721
GO:0006955	Process	Immune response	TAS	9725260
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9725260
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0030594	Function	Neurotransmitter receptor activity	IBA
GO:0045202	Component	Synapse	IEA
GO:0045907	Process	Positive regulation of vasoconstriction	IEA

MIM	HGNC	e!Ensembl
142703	5183	ENSG00000113749

P25021

Protein name

Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)

Protein function

The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is me

PDB

7UL3 , 8POK , 8YN3 , 8YN4 , 8YUT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	35 → 288	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR

Sequence length

359

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction Gastric acid secretion		Histamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Myoepithelial tumor	Uncertain significance	rs2480644210	RCV002463930

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	25922853, 40425926
Carcinoma Renal Cell	Associate	36059531, 37689589, 37781030
Cardiomyopathy Dilated	Associate	29191567
Colorectal Neoplasms	Associate	36902343
Cystitis Interstitial	Associate	31718622
Dermatitis Atopic	Associate	36142206
Eosinophilic Esophagitis	Stimulate	25723478
Food Hypersensitivity	Stimulate	16299042
Gastritis Atrophic	Associate	22720301
Gastrointestinal Diseases	Associate	16299042
Heart Failure	Associate	29191567
Helicobacter Infections	Associate	22720301
Inflammation	Inhibit	14744809
Inflammation	Associate	23280118, 25723478
Irritable Bowel Syndrome	Stimulate	16299042
Leukemia	Associate	22689678
Melanoma	Associate	15848191
Neoplasms	Associate	25922853
Parkinson Disease	Associate	18366640
Polycystic Ovary Syndrome	Associate	31278444
Stomach Diseases	Associate	22720301
Stomach Neoplasms	Associate	10371214
Tachycardia Sinoatrial Nodal Reentry	Associate	22720301
Tourette Syndrome	Associate	36674940

HRH2 (histamine receptor H2)