HRG (histidine rich glycoprotein)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3273
Gene name Histidine rich glycoprotein
Gene symbol HRG
Synonyms (NCBI Gene)
HPRGHRGPTHPH11
Chromosome 3
Chromosome location 3q27.3
Summary This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein a
miRNA miRNA information provided by mirtarbase database.
11
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (11)
miRTarBase ID miRNA Experiments Reference
MIRT1054641 hsa-miR-140-5p CLIP-seq
MIRT1054642 hsa-miR-3133 CLIP-seq
MIRT1054643 hsa-miR-3545-5p CLIP-seq
MIRT1054644 hsa-miR-4460 CLIP-seq
MIRT1054645 hsa-miR-4511 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
60
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (60)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0002839 Process Positive regulation of immune response to tumor cell IBA
GO:0002839 Process Positive regulation of immune response to tumor cell IDA 21215706
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA
GO:0004869 Function Cysteine-type endopeptidase inhibitor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
142640 5181 ENSG00000113905
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P04196
Protein name Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG)
Protein function Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on th
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00031 Cystatin 18 → 107 Cystatin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in macrophages and in malignant cells. Expressed by the liver and secreted in plasma (at protein level). {ECO:0000269|PubMed:14744774, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:21215706}.
Sequence 
MKALIAALLLITLQYSCAVSPTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHLDR
VENTTVYYLVLDVQESDCSVLSRKYWNDCEPPDSRRPSEIVIGQCKVIATRHSHESQDLR
VIDFNCTTSSVSSALANTKDSPVLIDFFEDTERYRKQANKALEKYKEENDDFASFRVDRI
ERVARVRGGEGTGYFVDFSVRNCPRHHFPRHPNVFGFCRADLFYDVEALDLESPKNLVIN
CEVFDPQEHENINGVPPHLGHPFHWGGHERSSTTKPPFKPHGSRDHHHPHKPHEHGPPPP
PDERDHSHGPPLPQGPPPLLPMSCSSCQHATFGTNGAQRHSHNNNSSDLHPHKHHSHEQH
PHGHHPHAHHPHEHDTHRQHPHGHHPHGHHPHGHHPHGHHPHGHHPHCHDFQDYGPCDPP
PHNQGHCCHGHGPPPGHLRRRGPGKGPRPFHCRQIGSVYRLPPLRKGEVLPLPEANFPSF
PLPHHKHPLKPDNQPFPQSVSESCPGKFKSGFPQVSMFFTHTFPK
Sequence length 525
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Platelet degranulation
Dissolution of Fibrin Clot
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial early-onset deep venous thrombosis Likely pathogenic; Pathogenic rs761776963 RCV000509067
Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency Pathogenic; Likely pathogenic rs121918122, rs761776963 RCV000016049
RCV000627095
Show/Hide Unknown Diseases (5)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Abnormal bleeding Likely benign rs148716747 RCV001270493
HRG-related disorder Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity rs9898, rs144288090, rs142020162, rs10770, rs146265787, rs150522400, rs200979058, rs146771057, rs2228243, rs533637172, rs116004251, rs115876426, rs115242562, rs114895145, rs2229331 RCV003976039
RCV003909302
RCV003929723
RCV003979634
RCV003937081
RCV003937196
RCV003964728
RCV003967112
RCV003976721
RCV003972160
RCV003940497
RCV003940498
RCV003940499
RCV003936268
RCV003973013
Malignant tumor of urinary bladder Uncertain significance rs775005977 RCV005927260
Thrombocytopenia Likely benign rs148716747 RCV001270493
Show/Hide Text Mining Associations (35)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 25064236
Abortion Spontaneous Associate 23672470, 25064236, 27210772
Acute On Chronic Liver Failure Associate 30867825
Adenocarcinoma of Lung Associate 37576511
Anemia Aplastic Associate 35571618
Bacterial Infections Associate 37244517
Blood Coagulation Disorders Associate 34232570
Brain Concussion Associate 36834989
Breast Neoplasms Associate 11134179, 18355957, 19386091, 21467033
Calcinosis Cutis Associate 27662660