Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3269
Gene name Gene Name - the full gene name approved by the HGNC.	Histamine receptor H1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HRH1
Synonyms (NCBI Gene) Gene synonyms aliases	H1-R, H1R, HH1R, hisH1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p25.3
Summary Summary of gene provided in NCBI Entrez Gene.	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein an

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004851	hsa-miR-192-5p	Luciferase reporter assay, qRT-PCR	19074876
MIRT022836	hsa-miR-124-3p	Microarray	18668037
MIRT004851	hsa-miR-192-5p	Reporter assay;Microarray;Other	19074876
MIRT644298	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT644297	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT644296	hsa-miR-3920	HITS-CLIP	23824327
MIRT644295	hsa-miR-29a-5p	HITS-CLIP	23824327
MIRT644294	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT644293	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT644291	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT644292	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT644290	hsa-miR-665	HITS-CLIP	23824327
MIRT644289	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT644288	hsa-miR-7977	HITS-CLIP	23824327
MIRT644287	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT445002	hsa-miR-1295b-3p	PAR-CLIP	22100165
MIRT445001	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445000	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT444999	hsa-miR-610	PAR-CLIP	22100165
MIRT444997	hsa-miR-4731-5p	PAR-CLIP	22100165
MIRT444998	hsa-miR-5589-5p	PAR-CLIP	22100165
MIRT444996	hsa-miR-5089-5p	PAR-CLIP	22100165
MIRT445002	hsa-miR-1295b-3p	PAR-CLIP	22100165
MIRT445001	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445000	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT444999	hsa-miR-610	PAR-CLIP	22100165
MIRT444997	hsa-miR-4731-5p	PAR-CLIP	22100165
MIRT444998	hsa-miR-5589-5p	PAR-CLIP	22100165
MIRT444996	hsa-miR-5089-5p	PAR-CLIP	22100165
MIRT644298	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT644297	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT644296	hsa-miR-3920	HITS-CLIP	23824327
MIRT644295	hsa-miR-29a-5p	HITS-CLIP	23824327
MIRT644294	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT644293	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT644291	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT644292	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT644290	hsa-miR-665	HITS-CLIP	23824327
MIRT644289	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT644288	hsa-miR-7977	HITS-CLIP	23824327
MIRT644287	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT445002	hsa-miR-1295b-3p	PAR-CLIP	22100165
MIRT445001	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445000	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT444999	hsa-miR-610	PAR-CLIP	22100165
MIRT444997	hsa-miR-4731-5p	PAR-CLIP	22100165
MIRT444998	hsa-miR-5589-5p	PAR-CLIP	22100165
MIRT444996	hsa-miR-5089-5p	PAR-CLIP	22100165
MIRT445002	hsa-miR-1295b-3p	PAR-CLIP	22100165
MIRT445001	hsa-miR-619-5p	PAR-CLIP	22100165
MIRT445000	hsa-miR-6506-5p	PAR-CLIP	22100165
MIRT444999	hsa-miR-610	PAR-CLIP	22100165
MIRT444997	hsa-miR-4731-5p	PAR-CLIP	22100165
MIRT444998	hsa-miR-5589-5p	PAR-CLIP	22100165
MIRT444996	hsa-miR-5089-5p	PAR-CLIP	22100165
MIRT756046	hsa-miR-3202	Microarray, qRT-PCR	35899934
MIRT756047	hsa-miR-583	Microarray, qRT-PCR	35899934
MIRT1054651	hsa-miR-105	CLIP-seq
MIRT1054652	hsa-miR-183	CLIP-seq
MIRT1054653	hsa-miR-2278	CLIP-seq
MIRT1054654	hsa-miR-3161	CLIP-seq
MIRT1054655	hsa-miR-3176	CLIP-seq
MIRT1054656	hsa-miR-3189-5p	CLIP-seq
MIRT1054657	hsa-miR-3199	CLIP-seq
MIRT1054658	hsa-miR-323-3p	CLIP-seq
MIRT1054659	hsa-miR-323b-3p	CLIP-seq
MIRT1054660	hsa-miR-3545-3p	CLIP-seq
MIRT1054661	hsa-miR-3663-5p	CLIP-seq
MIRT1054662	hsa-miR-3922-3p	CLIP-seq
MIRT1054663	hsa-miR-4438	CLIP-seq
MIRT1054664	hsa-miR-4463	CLIP-seq
MIRT1054665	hsa-miR-4468	CLIP-seq
MIRT1054666	hsa-miR-4494	CLIP-seq
MIRT1054667	hsa-miR-4635	CLIP-seq
MIRT1054668	hsa-miR-4648	CLIP-seq
MIRT1054669	hsa-miR-4680-5p	CLIP-seq
MIRT1054670	hsa-miR-4757-5p	CLIP-seq
MIRT1054671	hsa-miR-4758-3p	CLIP-seq
MIRT1054672	hsa-miR-5095	CLIP-seq
MIRT1054673	hsa-miR-1279	CLIP-seq
MIRT1054674	hsa-miR-136	CLIP-seq
MIRT1054675	hsa-miR-3187-3p	CLIP-seq
MIRT1054661	hsa-miR-3663-5p	CLIP-seq
MIRT1054676	hsa-miR-4435	CLIP-seq
MIRT1054664	hsa-miR-4463	CLIP-seq
MIRT1054666	hsa-miR-4494	CLIP-seq
MIRT1054667	hsa-miR-4635	CLIP-seq
MIRT1054677	hsa-miR-4701-5p	CLIP-seq
MIRT1054678	hsa-miR-515-5p	CLIP-seq
MIRT1054679	hsa-miR-548s	CLIP-seq
MIRT1054680	hsa-miR-588	CLIP-seq
MIRT2012431	hsa-miR-593	CLIP-seq
MIRT2244717	hsa-miR-122	CLIP-seq
MIRT2244718	hsa-miR-1267	CLIP-seq
MIRT2244719	hsa-miR-142-5p	CLIP-seq
MIRT2244720	hsa-miR-24	CLIP-seq
MIRT2244721	hsa-miR-3135b	CLIP-seq
MIRT2244722	hsa-miR-3143	CLIP-seq
MIRT2244723	hsa-miR-3194-3p	CLIP-seq
MIRT2244724	hsa-miR-3652	CLIP-seq
MIRT2244725	hsa-miR-4284	CLIP-seq
MIRT2244726	hsa-miR-431	CLIP-seq
MIRT2244727	hsa-miR-4423-5p	CLIP-seq
MIRT2244728	hsa-miR-4430	CLIP-seq
MIRT2244729	hsa-miR-4797-5p	CLIP-seq
MIRT2244730	hsa-miR-543	CLIP-seq
MIRT2244731	hsa-miR-544b	CLIP-seq
MIRT2244732	hsa-miR-548al	CLIP-seq
MIRT2244733	hsa-miR-924	CLIP-seq
MIRT2244717	hsa-miR-122	CLIP-seq
MIRT2244718	hsa-miR-1267	CLIP-seq
MIRT2451375	hsa-miR-2113	CLIP-seq
MIRT2244721	hsa-miR-3135b	CLIP-seq
MIRT2244723	hsa-miR-3194-3p	CLIP-seq
MIRT2244724	hsa-miR-3652	CLIP-seq
MIRT2451376	hsa-miR-411	CLIP-seq
MIRT2244726	hsa-miR-431	CLIP-seq
MIRT2244727	hsa-miR-4423-5p	CLIP-seq
MIRT2244728	hsa-miR-4430	CLIP-seq
MIRT2451377	hsa-miR-4775	CLIP-seq
MIRT2244729	hsa-miR-4797-5p	CLIP-seq
MIRT2451378	hsa-miR-590-3p	CLIP-seq
MIRT2451379	hsa-miR-599	CLIP-seq
MIRT2244733	hsa-miR-924	CLIP-seq
MIRT2547664	hsa-miR-1207-3p	CLIP-seq
MIRT2244717	hsa-miR-122	CLIP-seq
MIRT2547665	hsa-miR-1229	CLIP-seq
MIRT2244718	hsa-miR-1267	CLIP-seq
MIRT2547666	hsa-miR-19a	CLIP-seq
MIRT2547667	hsa-miR-19b	CLIP-seq
MIRT2547668	hsa-miR-205	CLIP-seq
MIRT2451375	hsa-miR-2113	CLIP-seq
MIRT2244720	hsa-miR-24	CLIP-seq
MIRT2547669	hsa-miR-297	CLIP-seq
MIRT2547670	hsa-miR-3127-3p	CLIP-seq
MIRT2244721	hsa-miR-3135b	CLIP-seq
MIRT2547671	hsa-miR-3170	CLIP-seq
MIRT2547672	hsa-miR-3189-3p	CLIP-seq
MIRT2244723	hsa-miR-3194-3p	CLIP-seq
MIRT2547673	hsa-miR-330-3p	CLIP-seq
MIRT2547674	hsa-miR-342-3p	CLIP-seq
MIRT2547675	hsa-miR-3614-5p	CLIP-seq
MIRT2244724	hsa-miR-3652	CLIP-seq
MIRT2451376	hsa-miR-411	CLIP-seq
MIRT2547676	hsa-miR-4260	CLIP-seq
MIRT2244725	hsa-miR-4284	CLIP-seq
MIRT2244726	hsa-miR-431	CLIP-seq
MIRT2547677	hsa-miR-4325	CLIP-seq
MIRT2244727	hsa-miR-4423-5p	CLIP-seq
MIRT2244728	hsa-miR-4430	CLIP-seq
MIRT2547678	hsa-miR-4455	CLIP-seq
MIRT2547679	hsa-miR-4471	CLIP-seq
MIRT2547680	hsa-miR-4501	CLIP-seq
MIRT2547681	hsa-miR-4532	CLIP-seq
MIRT2547682	hsa-miR-4661-5p	CLIP-seq
MIRT2547683	hsa-miR-4662a-5p	CLIP-seq
MIRT2547684	hsa-miR-4681	CLIP-seq
MIRT2547685	hsa-miR-4715-3p	CLIP-seq
MIRT2547686	hsa-miR-4716-5p	CLIP-seq
MIRT2451377	hsa-miR-4775	CLIP-seq
MIRT2244729	hsa-miR-4797-5p	CLIP-seq
MIRT2547687	hsa-miR-498	CLIP-seq
MIRT2244732	hsa-miR-548al	CLIP-seq
MIRT2547688	hsa-miR-548c-3p	CLIP-seq
MIRT2547689	hsa-miR-548u	CLIP-seq
MIRT2547690	hsa-miR-567	CLIP-seq
MIRT2547691	hsa-miR-577	CLIP-seq
MIRT2451378	hsa-miR-590-3p	CLIP-seq
MIRT2451379	hsa-miR-599	CLIP-seq
MIRT2547692	hsa-miR-609	CLIP-seq
MIRT2547693	hsa-miR-633	CLIP-seq
MIRT2547694	hsa-miR-635	CLIP-seq
MIRT2547695	hsa-miR-659	CLIP-seq
MIRT2244733	hsa-miR-924	CLIP-seq
MIRT2244717	hsa-miR-122	CLIP-seq
MIRT2244718	hsa-miR-1267	CLIP-seq
MIRT2682456	hsa-miR-2053	CLIP-seq
MIRT2244720	hsa-miR-24	CLIP-seq
MIRT2547669	hsa-miR-297	CLIP-seq
MIRT2244721	hsa-miR-3135b	CLIP-seq
MIRT2244723	hsa-miR-3194-3p	CLIP-seq
MIRT2682457	hsa-miR-3616-3p	CLIP-seq
MIRT2244724	hsa-miR-3652	CLIP-seq
MIRT2244725	hsa-miR-4284	CLIP-seq
MIRT2244726	hsa-miR-431	CLIP-seq
MIRT2244727	hsa-miR-4423-5p	CLIP-seq
MIRT2244728	hsa-miR-4430	CLIP-seq
MIRT2547685	hsa-miR-4715-3p	CLIP-seq
MIRT2244729	hsa-miR-4797-5p	CLIP-seq
MIRT2244732	hsa-miR-548al	CLIP-seq
MIRT2547690	hsa-miR-567	CLIP-seq
MIRT2547694	hsa-miR-635	CLIP-seq
MIRT2244733	hsa-miR-924	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
MYB	Unknown	24535227
NR3C1	Unknown	24535227
STAT5A	Unknown	24535227

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	IBA
GO:0004969	Function	Histamine receptor activity	IDA	8280179, 33828102
GO:0004969	Function	Histamine receptor activity	IEA
GO:0004969	Function	Histamine receptor activity	ISS
GO:0004969	Function	Histamine receptor activity	TAS	10818238
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	8280179
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS	7925364
GO:0006954	Process	Inflammatory response	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	8280179, 33828102
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007208	Process	Phospholipase C-activating serotonin receptor signaling pathway	IDA	37991948
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007613	Process	Memory	IEA
GO:0008542	Process	Visual learning	IEA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IBA
GO:0043114	Process	Regulation of vascular permeability	IEA
GO:0045202	Component	Synapse	IEA
GO:0045907	Process	Positive regulation of vasoconstriction	IEA
GO:0048167	Process	Regulation of synaptic plasticity	IEA
GO:0071420	Process	Cellular response to histamine	IDA	8280179, 33828102
GO:0071420	Process	Cellular response to histamine	ISS

MIM	HGNC	e!Ensembl
600167	5182	ENSG00000196639

Protein

UniProt ID

P35367

Protein name

Histamine H1 receptor (H1-R) (H1R) (HH1R)

Protein function

G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increase

PDB

3RZE , 7DFL , 8YN2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	44 → 468	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS

Sequence length

487

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction Inflammatory mediator regulation of TRP channels		Histamine receptors G alpha (q) signalling events

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Insomnia	Insomnia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Asthma	Associate	15661077, 25295384, 26635083
Asthma	Stimulate	25909280
Atherosclerosis	Associate	7717464
Breast Neoplasms	Associate	26673618
Carcinoma Endometrioid	Associate	25045085
Carcinoma Hepatocellular	Associate	29425759, 31740780
Cardiovascular Diseases	Associate	7717464
Conjunctival Diseases	Associate	28391980
Cystitis Interstitial	Stimulate	31718622
Dermatitis Atopic	Associate	26635083, 39684538
Diabetes Mellitus	Associate	21336576
Drug Hypersensitivity	Associate	18714531, 26391399, 34822775
Drug Hypersensitivity	Stimulate	25909280, 30742585
Drug Hypersensitivity Syndrome	Associate	21730054, 26391399
Eosinophilic Esophagitis	Stimulate	25723478
Fatty Liver Alcoholic	Inhibit	29425759
Food Hypersensitivity	Stimulate	16299042
Gastrointestinal Diseases	Associate	16299042
Hepatitis Alcoholic	Stimulate	29425759
Inflammation	Associate	26635083
Irritable Bowel Syndrome	Stimulate	16299042
Leukemia Myeloid Acute	Associate	39918973
Lymphangioleiomyomatosis	Associate	34378323
Neoplasms	Associate	26673618, 31740780, 33452347, 34822775, 35587368
Nose Diseases	Associate	17460445, 21225011, 26598006
Obesity	Associate	21336576
Psychotic Disorders	Associate	21336576
Reperfusion Injury	Associate	36253874
Rhinitis	Associate	23132961
Rhinitis Allergic	Associate	21730054, 23132961, 26391399, 26635083
Rhinitis Allergic Perennial	Associate	23132961
Rhinitis Allergic Seasonal	Associate	21225011, 26598006
Sarcoma Kaposi	Associate	31969437
Squamous Cell Carcinoma of Head and Neck	Associate	35587368
T cell immunodeficiency primary	Stimulate	34822775
upper airway cough syndrome	Associate	23132961
Weight Gain	Associate	21336576

HRH1 (histamine receptor H1)