HOXD1 (homeobox D1)

Gene

• Entrez ID: 3231
• Gene name: Homeobox D1
• Gene symbol: HOXD1
• Synonyms (NCBI Gene): HOX4, HOX4G, Hox-4.7
• Chromosome: 2
• Chromosome location: 2q31.1
• Summary: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT536762	hsa-miR-125b-5p	PAR-CLIP	22012620
MIRT536761	hsa-miR-125a-5p	PAR-CLIP	22012620
MIRT536760	hsa-miR-4319	PAR-CLIP	22012620
MIRT536759	hsa-miR-3617-5p	PAR-CLIP	22012620
MIRT536758	hsa-miR-641	PAR-CLIP	22012620
MIRT536757	hsa-miR-4719	PAR-CLIP	22012620
MIRT536756	hsa-miR-345-3p	PAR-CLIP	22012620
MIRT536755	hsa-miR-4732-3p	PAR-CLIP	22012620
MIRT536754	hsa-miR-670-5p	PAR-CLIP	22012620
MIRT536753	hsa-miR-3161	PAR-CLIP	22012620
MIRT439158	hsa-let-7c-5p	3'LIFE	25074381
MIRT439124	hsa-miR-10b-5p	3'LIFE	25074381
MIRT439158	hsa-let-7c-5p	3'LIFE	25074381
MIRT439124	hsa-miR-10b-5p	3'LIFE	25074381
MIRT536762	hsa-miR-125b-5p	PAR-CLIP	22012620
MIRT536761	hsa-miR-125a-5p	PAR-CLIP	22012620
MIRT536760	hsa-miR-4319	PAR-CLIP	22012620
MIRT536759	hsa-miR-3617-5p	PAR-CLIP	22012620
MIRT536758	hsa-miR-641	PAR-CLIP	22012620
MIRT536757	hsa-miR-4719	PAR-CLIP	22012620
MIRT536756	hsa-miR-345-3p	PAR-CLIP	22012620
MIRT536755	hsa-miR-4732-3p	PAR-CLIP	22012620
MIRT536754	hsa-miR-670-5p	PAR-CLIP	22012620
MIRT536753	hsa-miR-3161	PAR-CLIP	22012620
MIRT1053744	hsa-miR-1587	CLIP-seq
MIRT1053745	hsa-miR-15a	CLIP-seq
MIRT1053746	hsa-miR-15b	CLIP-seq
MIRT1053747	hsa-miR-16	CLIP-seq
MIRT1053748	hsa-miR-195	CLIP-seq
MIRT1053749	hsa-miR-3182	CLIP-seq
MIRT1053750	hsa-miR-3663-3p	CLIP-seq
MIRT1053751	hsa-miR-378g	CLIP-seq
MIRT1053752	hsa-miR-424	CLIP-seq
MIRT1053753	hsa-miR-4303	CLIP-seq
MIRT1053754	hsa-miR-4487	CLIP-seq
MIRT1053755	hsa-miR-4492	CLIP-seq
MIRT1053756	hsa-miR-4498	CLIP-seq
MIRT1053757	hsa-miR-4524	CLIP-seq
MIRT1053758	hsa-miR-4656	CLIP-seq
MIRT1053759	hsa-miR-4675	CLIP-seq
MIRT1053760	hsa-miR-4741	CLIP-seq
MIRT1053761	hsa-miR-497	CLIP-seq
MIRT1053762	hsa-miR-503	CLIP-seq
MIRT1053763	hsa-miR-512-3p	CLIP-seq
MIRT1053764	hsa-miR-646	CLIP-seq
MIRT1053765	hsa-miR-759	CLIP-seq
MIRT1053766	hsa-miR-762	CLIP-seq
MIRT1053767	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0048706	Process	Embryonic skeletal system development	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 142987
• HGNC: 5132
• e!Ensembl: ENSG00000128645

Protein

• UniProt ID: Q9GZZ0
• Protein name: Homeobox protein Hox-D1 (Homeobox protein Hox-GG)
• Protein function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00046	Homeodomain	231 → 286	Homeodomain	Domain

• Sequence:

  MSSYLEYVSCSSSGGVGGDVLSLAPKFCRSDARPVALQPAFPLGNGDGAFVSCLPLAAAR
  PSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGV
  LGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKASADGHPGAFQT
  ASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQ
  LTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVA
  PLQLPLSGTTPTKFIKNPGSPSQSQEPS

• Sequence length: 328

Pathways

KEGG:

Signaling pathways regulating pluripotency of stem cells