Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	3217
Gene name	Homeobox B7
Gene symbol	HOXB7
Synonyms (NCBI Gene)	HHO.C1HOX2HOX2CHox-2.3
Chromosome	17
Chromosome location	17q21.32
Summary	This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcriptio

151

Show/Hide all (151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004244	hsa-miR-196a-5p	ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot	20480203
MIRT004244	hsa-miR-196a-5p	ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot	20480203
MIRT030282	hsa-miR-26b-5p	Microarray	19088304
MIRT438111	hsa-miR-196b-5p	Luciferase reporter assay	23861821
MIRT438111	hsa-miR-196b-5p	Luciferase reporter assay	23861821
MIRT1053382	hsa-miR-129-5p	CLIP-seq
MIRT1053383	hsa-miR-1470	CLIP-seq
MIRT1053384	hsa-miR-296-3p	CLIP-seq
MIRT1053385	hsa-miR-3121-3p	CLIP-seq
MIRT1053386	hsa-miR-3180-5p	CLIP-seq
MIRT1053387	hsa-miR-3927	CLIP-seq
MIRT1053388	hsa-miR-3935	CLIP-seq
MIRT1053389	hsa-miR-4279	CLIP-seq
MIRT1053390	hsa-miR-4287	CLIP-seq
MIRT1053391	hsa-miR-4469	CLIP-seq
MIRT1053392	hsa-miR-4667-3p	CLIP-seq
MIRT1053393	hsa-miR-4685-3p	CLIP-seq
MIRT1053394	hsa-miR-4713-5p	CLIP-seq
MIRT1053395	hsa-miR-4773	CLIP-seq
MIRT1053396	hsa-miR-520a-5p	CLIP-seq
MIRT1053397	hsa-miR-525-5p	CLIP-seq
MIRT1053398	hsa-miR-548v	CLIP-seq
MIRT1053399	hsa-miR-577	CLIP-seq
MIRT1053400	hsa-miR-889	CLIP-seq
MIRT2012151	hsa-miR-1236	CLIP-seq
MIRT2012152	hsa-miR-204	CLIP-seq
MIRT2012153	hsa-miR-211	CLIP-seq
MIRT2012154	hsa-miR-593	CLIP-seq
MIRT1053400	hsa-miR-889	CLIP-seq
MIRT2012151	hsa-miR-1236	CLIP-seq
MIRT2244399	hsa-miR-1276	CLIP-seq
MIRT2244400	hsa-miR-1323	CLIP-seq
MIRT2244401	hsa-miR-140-3p	CLIP-seq
MIRT2244402	hsa-miR-15a	CLIP-seq
MIRT2244403	hsa-miR-15b	CLIP-seq
MIRT2244404	hsa-miR-16	CLIP-seq
MIRT2244405	hsa-miR-1913	CLIP-seq
MIRT2244406	hsa-miR-195	CLIP-seq
MIRT2244407	hsa-miR-196a	CLIP-seq
MIRT2244408	hsa-miR-196b	CLIP-seq
MIRT2244409	hsa-miR-198	CLIP-seq
MIRT2244410	hsa-miR-2110	CLIP-seq
MIRT2244411	hsa-miR-2276	CLIP-seq
MIRT2244412	hsa-miR-24	CLIP-seq
MIRT2244413	hsa-miR-2467-5p	CLIP-seq
MIRT2244414	hsa-miR-3124-3p	CLIP-seq
MIRT2244415	hsa-miR-3150a-3p	CLIP-seq
MIRT2244416	hsa-miR-3158-3p	CLIP-seq
MIRT1053386	hsa-miR-3180-5p	CLIP-seq
MIRT2244417	hsa-miR-324-3p	CLIP-seq
MIRT2244418	hsa-miR-337-3p	CLIP-seq
MIRT2244419	hsa-miR-338-5p	CLIP-seq
MIRT2244420	hsa-miR-3616-3p	CLIP-seq
MIRT2244421	hsa-miR-3660	CLIP-seq
MIRT2244422	hsa-miR-3664-3p	CLIP-seq
MIRT2244423	hsa-miR-3685	CLIP-seq
MIRT2244424	hsa-miR-376c	CLIP-seq
MIRT2244425	hsa-miR-384	CLIP-seq
MIRT1053387	hsa-miR-3927	CLIP-seq
MIRT2244426	hsa-miR-424	CLIP-seq
MIRT2244427	hsa-miR-4271	CLIP-seq
MIRT2244428	hsa-miR-4276	CLIP-seq
MIRT2244429	hsa-miR-4283	CLIP-seq
MIRT2244430	hsa-miR-4302	CLIP-seq
MIRT2244431	hsa-miR-4310	CLIP-seq
MIRT2244432	hsa-miR-4311	CLIP-seq
MIRT2244433	hsa-miR-4433	CLIP-seq
MIRT2244434	hsa-miR-4436b-3p	CLIP-seq
MIRT2244435	hsa-miR-4459	CLIP-seq
MIRT2244436	hsa-miR-4526	CLIP-seq
MIRT2244437	hsa-miR-4536	CLIP-seq
MIRT2244438	hsa-miR-4540	CLIP-seq
MIRT2244439	hsa-miR-455-3p	CLIP-seq
MIRT2244440	hsa-miR-4696	CLIP-seq
MIRT2244441	hsa-miR-4721	CLIP-seq
MIRT2244442	hsa-miR-4725-3p	CLIP-seq
MIRT2244443	hsa-miR-4742-5p	CLIP-seq
MIRT2244444	hsa-miR-4755-3p	CLIP-seq
MIRT2244445	hsa-miR-4768-3p	CLIP-seq
MIRT1053395	hsa-miR-4773	CLIP-seq
MIRT2244446	hsa-miR-4779	CLIP-seq
MIRT2244447	hsa-miR-497	CLIP-seq
MIRT2244448	hsa-miR-499a-5p	CLIP-seq
MIRT2244449	hsa-miR-515-5p	CLIP-seq
MIRT1053396	hsa-miR-520a-5p	CLIP-seq
MIRT2244450	hsa-miR-520d-5p	CLIP-seq
MIRT2244451	hsa-miR-524-5p	CLIP-seq
MIRT1053397	hsa-miR-525-5p	CLIP-seq
MIRT2244452	hsa-miR-548a-3p	CLIP-seq
MIRT2244453	hsa-miR-548e	CLIP-seq
MIRT2244454	hsa-miR-548f	CLIP-seq
MIRT2244455	hsa-miR-548o	CLIP-seq
MIRT1053398	hsa-miR-548v	CLIP-seq
MIRT2244456	hsa-miR-583	CLIP-seq
MIRT2244457	hsa-miR-658	CLIP-seq
MIRT2244458	hsa-miR-938	CLIP-seq
MIRT2442258	hsa-miR-4760-5p	CLIP-seq
MIRT2442259	hsa-miR-501-5p	CLIP-seq
MIRT2442260	hsa-miR-587	CLIP-seq
MIRT1053383	hsa-miR-1470	CLIP-seq
MIRT2244407	hsa-miR-196a	CLIP-seq
MIRT2244408	hsa-miR-196b	CLIP-seq
MIRT1053385	hsa-miR-3121-3p	CLIP-seq
MIRT2244414	hsa-miR-3124-3p	CLIP-seq
MIRT2244418	hsa-miR-337-3p	CLIP-seq
MIRT2244423	hsa-miR-3685	CLIP-seq
MIRT2244425	hsa-miR-384	CLIP-seq
MIRT1053387	hsa-miR-3927	CLIP-seq
MIRT2244428	hsa-miR-4276	CLIP-seq
MIRT1053389	hsa-miR-4279	CLIP-seq
MIRT2547385	hsa-miR-4282	CLIP-seq
MIRT1053390	hsa-miR-4287	CLIP-seq
MIRT2244430	hsa-miR-4302	CLIP-seq
MIRT2547386	hsa-miR-4307	CLIP-seq
MIRT1053391	hsa-miR-4469	CLIP-seq
MIRT1053392	hsa-miR-4667-3p	CLIP-seq
MIRT1053393	hsa-miR-4685-3p	CLIP-seq
MIRT1053394	hsa-miR-4713-5p	CLIP-seq
MIRT2547387	hsa-miR-4729	CLIP-seq
MIRT2244448	hsa-miR-499a-5p	CLIP-seq
MIRT2547388	hsa-miR-513a-3p	CLIP-seq
MIRT2547389	hsa-miR-548aa	CLIP-seq
MIRT2547390	hsa-miR-548ac	CLIP-seq
MIRT2547391	hsa-miR-548d-3p	CLIP-seq
MIRT2547392	hsa-miR-548z	CLIP-seq
MIRT2547393	hsa-miR-579	CLIP-seq
MIRT2547394	hsa-miR-653	CLIP-seq
MIRT1053383	hsa-miR-1470	CLIP-seq
MIRT2244407	hsa-miR-196a	CLIP-seq
MIRT2244408	hsa-miR-196b	CLIP-seq
MIRT2244414	hsa-miR-3124-3p	CLIP-seq
MIRT2244418	hsa-miR-337-3p	CLIP-seq
MIRT2244423	hsa-miR-3685	CLIP-seq
MIRT2244425	hsa-miR-384	CLIP-seq
MIRT1053387	hsa-miR-3927	CLIP-seq
MIRT2244428	hsa-miR-4276	CLIP-seq
MIRT1053389	hsa-miR-4279	CLIP-seq
MIRT2547385	hsa-miR-4282	CLIP-seq
MIRT1053390	hsa-miR-4287	CLIP-seq
MIRT2244430	hsa-miR-4302	CLIP-seq
MIRT1053391	hsa-miR-4469	CLIP-seq
MIRT1053392	hsa-miR-4667-3p	CLIP-seq
MIRT1053393	hsa-miR-4685-3p	CLIP-seq
MIRT1053394	hsa-miR-4713-5p	CLIP-seq
MIRT2244448	hsa-miR-499a-5p	CLIP-seq
MIRT2547388	hsa-miR-513a-3p	CLIP-seq
MIRT2547389	hsa-miR-548aa	CLIP-seq
MIRT2547390	hsa-miR-548ac	CLIP-seq
MIRT2547391	hsa-miR-548d-3p	CLIP-seq
MIRT2547392	hsa-miR-548z	CLIP-seq
MIRT2547394	hsa-miR-653	CLIP-seq

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Transcription factor	Regulation	Reference
NFYA	Unknown	12697323
NFYB	Unknown	12697323
NFYC	Unknown	12697323
SP1	Unknown	12697323
SP3	Unknown	12697323
USF1	Unknown	12697323
YY1	Unknown	12697323

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	8756643
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	8756643
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	1678287
GO:0005515	Function	Protein binding	IPI	17308091, 25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	1678287
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	1678287
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IBA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0030099	Process	Myeloid cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	8756643
GO:0048568	Process	Embryonic organ development	IEP	2885844
GO:0048704	Process	Embryonic skeletal system morphogenesis	IEA
GO:0090190	Process	Positive regulation of branching involved in ureteric bud morphogenesis	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
142962	5118	ENSG00000260027

P09629

Protein name

Homeobox protein Hox-B7 (Homeobox protein HHO.C1) (Homeobox protein Hox-2C)

Protein function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	138 → 194	Homeodomain	Domain

Sequence

MSSLYYANTLFSKYPASSSVFATGAFPEQTSCAFASNPQRPGYGAGSGASFAASMQGLYP
GGGGMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPGDSAKAAGAKEQRDSDLAA
ESNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQ
IKIWFQNRRMKWKKENKTAGPGTTGQDRAEAEEEEEE

Sequence length

217

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (40)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	30670912	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of Lung	Associate	38594917	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anophthalmia with pulmonary hypoplasia	Stimulate	24641834	★★★★★ ★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Stimulate	22603795	★★★★★ ★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Associate	30670912	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	10435624, 26014856, 26135503, 34680970	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	26307396, 33977077	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	28454092	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Stimulate	22914903	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Associate	24088503, 24641834, 25183455	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Stimulate	22879911	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Associate	24586698	★★★★★ ★☆☆☆☆ Found in Text Mining only
Constriction Pathologic	Associate	22879911, 27399126	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Stimulate	24641368	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	30964174	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Erythroblastic Acute	Associate	2573064	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Stimulate	38254070	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukoplakia	Stimulate	38408418	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	22914903, 24088503, 30964174	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	20480203, 23400877, 8756643	★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningomyelocele	Associate	27757173	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Associate	21953534	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Associate	38254070	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	28454092, 30964174	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	11274429, 12819026, 22914903, 24641834, 26014856, 26135503, 26307396, 27399126, 28454092, 36285482	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	24088503	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms Squamous Cell	Associate	24641368	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Associate	37534217	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oropharyngeal Neoplasms	Associate	36285482	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Stimulate	11274429	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Stimulate	22879911	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	22914903	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Associate	34101221	★★★★★ ★☆☆☆☆ Found in Text Mining only
Personality Disorders	Associate	34680970	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	24076275, 24519855, 33315534, 35945754, 36285482	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stimulate	26307396	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tachycardia Atrioventricular Nodal Reentry	Associate	40239580	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tertiary Lymphoid Structures	Associate	24641368	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	34680970	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	23861821	★★★★★ ★☆☆☆☆ Found in Text Mining only

HOXB7 (homeobox B7)