Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3213
Gene name Gene Name - the full gene name approved by the HGNC.	Homeobox B3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HOXB3
Synonyms (NCBI Gene) Gene synonyms aliases	HOX2, HOX2G, Hox-2.7
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcriptio

Show/Hide all(227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006838	hsa-miR-7-5p	Luciferase reporter assay	22705304
MIRT006839	hsa-miR-218-5p	Luciferase reporter assay	22705304
MIRT025627	hsa-miR-10a-5p	Sequencing	20371350
MIRT557091	hsa-miR-124-3p	PAR-CLIP	21572407
MIRT557090	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT557089	hsa-miR-5582-5p	PAR-CLIP	21572407
MIRT557088	hsa-miR-3929	PAR-CLIP	21572407
MIRT557087	hsa-miR-4419b	PAR-CLIP	21572407
MIRT557086	hsa-miR-4478	PAR-CLIP	21572407
MIRT557049	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT557048	hsa-miR-4459	PAR-CLIP	21572407
MIRT557047	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT557085	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT557084	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT557083	hsa-miR-4708-3p	PAR-CLIP	21572407
MIRT557082	hsa-miR-4663	PAR-CLIP	21572407
MIRT557081	hsa-miR-4653-5p	PAR-CLIP	21572407
MIRT557080	hsa-miR-665	PAR-CLIP	21572407
MIRT557079	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT557078	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT557077	hsa-miR-4295	PAR-CLIP	21572407
MIRT557076	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT557075	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT557074	hsa-miR-3666	PAR-CLIP	21572407
MIRT557073	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT557072	hsa-miR-520b	PAR-CLIP	21572407
MIRT557071	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT557070	hsa-miR-302e	PAR-CLIP	21572407
MIRT557069	hsa-miR-520e	PAR-CLIP	21572407
MIRT557068	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT557067	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT557066	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT557065	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT557064	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT557063	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT557062	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT557061	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT557060	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT557059	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT557058	hsa-miR-3662	PAR-CLIP	21572407
MIRT557057	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT557056	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT557055	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT557054	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT287771	hsa-miR-4495	PAR-CLIP	21572407
MIRT557053	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT557052	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT557051	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT557050	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT557049	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT557048	hsa-miR-4459	PAR-CLIP	21572407
MIRT557047	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT557046	hsa-miR-885-5p	PAR-CLIP	21572407
MIRT557045	hsa-miR-6748-3p	PAR-CLIP	21572407
MIRT557044	hsa-miR-4421	PAR-CLIP	21572407
MIRT557043	hsa-miR-5699-3p	PAR-CLIP	21572407
MIRT557042	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT557041	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT557040	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT557039	hsa-miR-4263	PAR-CLIP	21572407
MIRT557038	hsa-miR-2681-5p	PAR-CLIP	21572407
MIRT025627	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT506958	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT506957	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT506956	hsa-miR-504-5p	PAR-CLIP	21572407
MIRT506955	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT506954	hsa-miR-3671	PAR-CLIP	21572407
MIRT506953	hsa-miR-607	PAR-CLIP	21572407
MIRT547898	hsa-miR-375	PAR-CLIP	21572407
MIRT547897	hsa-miR-6739-3p	PAR-CLIP	21572407
MIRT506952	hsa-miR-5096	PAR-CLIP	21572407
MIRT025627	hsa-miR-10a-5p	PAR-CLIP	23446348
MIRT506958	hsa-miR-10b-5p	PAR-CLIP	23446348
MIRT506957	hsa-miR-224-5p	PAR-CLIP	23446348
MIRT506956	hsa-miR-504-5p	PAR-CLIP	23446348
MIRT506955	hsa-miR-335-5p	PAR-CLIP	23446348
MIRT506954	hsa-miR-3671	PAR-CLIP	23446348
MIRT506953	hsa-miR-607	PAR-CLIP	23446348
MIRT506952	hsa-miR-5096	PAR-CLIP	23446348
MIRT506958	hsa-miR-10b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27447302
MIRT557091	hsa-miR-124-3p	PAR-CLIP	21572407
MIRT557090	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT557089	hsa-miR-5582-5p	PAR-CLIP	21572407
MIRT557088	hsa-miR-3929	PAR-CLIP	21572407
MIRT557087	hsa-miR-4419b	PAR-CLIP	21572407
MIRT557086	hsa-miR-4478	PAR-CLIP	21572407
MIRT557049	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT557048	hsa-miR-4459	PAR-CLIP	21572407
MIRT557047	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT557085	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT557084	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT557083	hsa-miR-4708-3p	PAR-CLIP	21572407
MIRT557082	hsa-miR-4663	PAR-CLIP	21572407
MIRT557081	hsa-miR-4653-5p	PAR-CLIP	21572407
MIRT557080	hsa-miR-665	PAR-CLIP	21572407
MIRT557079	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT557078	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT557077	hsa-miR-4295	PAR-CLIP	21572407
MIRT557076	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT557075	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT557074	hsa-miR-3666	PAR-CLIP	21572407
MIRT557073	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT557072	hsa-miR-520b	PAR-CLIP	21572407
MIRT557071	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT557070	hsa-miR-302e	PAR-CLIP	21572407
MIRT557069	hsa-miR-520e	PAR-CLIP	21572407
MIRT557068	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT557067	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT557066	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT557065	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT557064	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT557063	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT557062	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT557061	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT557060	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT557059	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT557058	hsa-miR-3662	PAR-CLIP	21572407
MIRT557057	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT557056	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT557055	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT557054	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT287771	hsa-miR-4495	PAR-CLIP	21572407
MIRT557053	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT557052	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT557051	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT557050	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT557049	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT557048	hsa-miR-4459	PAR-CLIP	21572407
MIRT557047	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT557046	hsa-miR-885-5p	PAR-CLIP	21572407
MIRT557045	hsa-miR-6748-3p	PAR-CLIP	21572407
MIRT557044	hsa-miR-4421	PAR-CLIP	21572407
MIRT557043	hsa-miR-5699-3p	PAR-CLIP	21572407
MIRT557042	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT557041	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT557040	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT557039	hsa-miR-4263	PAR-CLIP	21572407
MIRT557038	hsa-miR-2681-5p	PAR-CLIP	21572407
MIRT025627	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT506958	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT506957	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT506956	hsa-miR-504-5p	PAR-CLIP	21572407
MIRT506955	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT506954	hsa-miR-3671	PAR-CLIP	21572407
MIRT506953	hsa-miR-607	PAR-CLIP	21572407
MIRT547898	hsa-miR-375	PAR-CLIP	21572407
MIRT547897	hsa-miR-6739-3p	PAR-CLIP	21572407
MIRT506952	hsa-miR-5096	PAR-CLIP	21572407
MIRT025627	hsa-miR-10a-5p	PAR-CLIP	23446348
MIRT506958	hsa-miR-10b-5p	PAR-CLIP	23446348
MIRT506957	hsa-miR-224-5p	PAR-CLIP	23446348
MIRT506956	hsa-miR-504-5p	PAR-CLIP	23446348
MIRT506955	hsa-miR-335-5p	PAR-CLIP	23446348
MIRT506954	hsa-miR-3671	PAR-CLIP	23446348
MIRT506953	hsa-miR-607	PAR-CLIP	23446348
MIRT506952	hsa-miR-5096	PAR-CLIP	23446348
MIRT1053309	hsa-miR-1283	CLIP-seq
MIRT1053310	hsa-miR-1284	CLIP-seq
MIRT1053311	hsa-miR-3148	CLIP-seq
MIRT1053312	hsa-miR-3168	CLIP-seq
MIRT1053313	hsa-miR-3185	CLIP-seq
MIRT1053314	hsa-miR-4436a	CLIP-seq
MIRT1053315	hsa-miR-4724-5p	CLIP-seq
MIRT1053316	hsa-miR-4759	CLIP-seq
MIRT1053317	hsa-miR-548a-5p	CLIP-seq
MIRT1053318	hsa-miR-548ab	CLIP-seq
MIRT1053319	hsa-miR-548ak	CLIP-seq
MIRT1053320	hsa-miR-548b-5p	CLIP-seq
MIRT1053321	hsa-miR-548c-5p	CLIP-seq
MIRT1053322	hsa-miR-548d-5p	CLIP-seq
MIRT1053323	hsa-miR-548h	CLIP-seq
MIRT1053324	hsa-miR-548i	CLIP-seq
MIRT1053325	hsa-miR-548j	CLIP-seq
MIRT1053326	hsa-miR-548n	CLIP-seq
MIRT1053327	hsa-miR-548w	CLIP-seq
MIRT1053328	hsa-miR-548y	CLIP-seq
MIRT1053329	hsa-miR-559	CLIP-seq
MIRT1053330	hsa-miR-606	CLIP-seq
MIRT2012146	hsa-miR-1236	CLIP-seq
MIRT2012147	hsa-miR-3135b	CLIP-seq
MIRT2012148	hsa-miR-4691-5p	CLIP-seq
MIRT2451338	hsa-miR-1275	CLIP-seq
MIRT2451339	hsa-miR-4260	CLIP-seq
MIRT2451340	hsa-miR-4665-5p	CLIP-seq
MIRT2451341	hsa-miR-548c-3p	CLIP-seq
MIRT2451342	hsa-miR-625	CLIP-seq
MIRT1053309	hsa-miR-1283	CLIP-seq
MIRT2547331	hsa-miR-2682	CLIP-seq
MIRT1053311	hsa-miR-3148	CLIP-seq
MIRT1053312	hsa-miR-3168	CLIP-seq
MIRT1053313	hsa-miR-3185	CLIP-seq
MIRT2547332	hsa-miR-331-5p	CLIP-seq
MIRT2547333	hsa-miR-449c	CLIP-seq
MIRT2547334	hsa-miR-4660	CLIP-seq
MIRT1053315	hsa-miR-4724-5p	CLIP-seq
MIRT2547335	hsa-miR-4764-3p	CLIP-seq
MIRT1053317	hsa-miR-548a-5p	CLIP-seq
MIRT1053318	hsa-miR-548ab	CLIP-seq
MIRT1053319	hsa-miR-548ak	CLIP-seq
MIRT1053320	hsa-miR-548b-5p	CLIP-seq
MIRT1053321	hsa-miR-548c-5p	CLIP-seq
MIRT1053322	hsa-miR-548d-5p	CLIP-seq
MIRT1053323	hsa-miR-548h	CLIP-seq
MIRT1053324	hsa-miR-548i	CLIP-seq
MIRT1053325	hsa-miR-548j	CLIP-seq
MIRT1053326	hsa-miR-548n	CLIP-seq
MIRT1053327	hsa-miR-548w	CLIP-seq
MIRT1053328	hsa-miR-548y	CLIP-seq
MIRT1053329	hsa-miR-559	CLIP-seq
MIRT1053330	hsa-miR-606	CLIP-seq
MIRT2547336	hsa-miR-618	CLIP-seq
MIRT2547337	hsa-miR-940	CLIP-seq
MIRT1053311	hsa-miR-3148	CLIP-seq
MIRT2547332	hsa-miR-331-5p	CLIP-seq
MIRT1053317	hsa-miR-548a-5p	CLIP-seq
MIRT1053318	hsa-miR-548ab	CLIP-seq
MIRT1053319	hsa-miR-548ak	CLIP-seq
MIRT1053320	hsa-miR-548b-5p	CLIP-seq
MIRT1053321	hsa-miR-548c-5p	CLIP-seq
MIRT1053322	hsa-miR-548d-5p	CLIP-seq
MIRT1053323	hsa-miR-548h	CLIP-seq
MIRT1053324	hsa-miR-548i	CLIP-seq
MIRT1053325	hsa-miR-548j	CLIP-seq
MIRT1053326	hsa-miR-548n	CLIP-seq
MIRT1053327	hsa-miR-548w	CLIP-seq
MIRT1053328	hsa-miR-548y	CLIP-seq
MIRT1053329	hsa-miR-559	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	7913891
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	9556594
GO:0001525	Process	Angiogenesis	IEP	17972163
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0009952	Process	Anterior/posterior pattern specification	IBA	21873635
GO:0021546	Process	Rhombomere development	IEA
GO:0021615	Process	Glossopharyngeal nerve morphogenesis	IEA
GO:0030878	Process	Thyroid gland development	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9556594
GO:0048704	Process	Embryonic skeletal system morphogenesis	IBA	21873635
GO:0050767	Process	Regulation of neurogenesis	IEA
GO:0051216	Process	Cartilage development	IEA
GO:0060216	Process	Definitive hemopoiesis	IEA
GO:0060324	Process	Face development	IEA

MIM	HGNC	e!Ensembl
142966	5114	ENSG00000120093

Protein

UniProt ID

P14651

Protein name

Homeobox protein Hox-B3 (Homeobox protein Hox-2.7) (Homeobox protein Hox-2G)

Protein function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	189 → 245	Homeodomain	Domain
PF13293	DUF4074	365 → 429	Domain of unknown function (DUF4074)	Family

Sequence

MQKATYYDNAAAALFGGYSSYPGSNGFGFDVPPQPPFQAATHLEGDYQRSACSLQSLGNA
APHAKSKELNGSCMRPGLAPEPLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKCGPG
TNSTLTKQIFPWMKESRQTSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDK
SPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRR
MKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTAGFMNALHSMTPSYESPSPPAFGKAHQN
AYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYAD
PLPPPAGPSLYGLNHLSHHPSGNLDYNGAPPMAPSQHHGPCEPHPTYTDLSSHHAPPPQG
RIQEAPKLTHL

Sequence length

431

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Obesity	Obesity	rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562 View all (27 more)	22484627

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Source
Unknown
Hypertension	Hypertension	GWAS
Motion Sickness	Motion Sickness	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS
Insomnia	Insomnia	GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	27782156
Carcinoma Hepatocellular	Associate	35127344
Carcinoma Ovarian Epithelial	Associate	30559148
Death	Associate	36973255
Graves Ophthalmopathy	Associate	29214313
Leukemia Monocytic Acute	Associate	10765922
Leukemia Myeloid Acute	Associate	25996682
Leukemia Myeloid Acute	Stimulate	38254070
Myelodysplastic Syndromes	Associate	38254070
Neoplasm Metastasis	Inhibit	32673827
Neoplasms	Associate	36973255
Prostatic Neoplasms Castration Resistant	Associate	36973255

HOXB3 (homeobox B3)