Gene Gene information from NCBI Gene database.
Entrez ID 3206
Gene name Homeobox A10
Gene symbol HOXA10
Synonyms (NCBI Gene)
HOX1HOX1.8HOX1HPL
Chromosome 7
Chromosome location 7p15.2
Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic develo
miRNA miRNA information provided by mirtarbase database.
734
miRTarBase ID miRNA Experiments Reference
MIRT000190 hsa-miR-204-5p Review 20029422
MIRT004850 hsa-miR-192-5p Luciferase reporter assayqRT-PCR 19074876
MIRT000190 hsa-miR-204-5p MicroarrayWestern blot 18308931
MIRT005441 hsa-miR-130a-3p Luciferase reporter assayMicroarrayqRT-PCR 20981674
MIRT006793 hsa-miR-135a-5p Luciferase reporter assay 22439757
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Transcription factor Regulation Reference
CREBBP Activation 16849538
GZF1 Repression 16049025
HOXA11 Repression 17688409
VDR Activation 15905361
WT1 Unknown 23888944
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 21471217
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
142957 5100 ENSG00000253293
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P31260
Protein name Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL)
Protein function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00046 Homeodomain 337 393 Homeodomain Domain
Sequence
MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGGGGGGAGGGGGGGYYAH
GGVYLPPAADLPYGLQSCGLFPTLGGKRNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLD
APRSCRMEPPDGPPPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPK
VSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGP
FPAQPPGRGFDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAE
ELSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMY
LTRERRLEISRSVHLTDRQVKIWFQNRRMKLKK
MNRENRIRELTANFNFS
Sequence length 410
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Transcriptional misregulation in cancer  
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
11
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
HOXA10-related disorder Benign; Likely benign rs112203709, rs576560374, rs202173149, rs373374162, rs150556405, rs34283323, rs753331027, rs759973639, rs34957925, rs201128593, rs34720764 RCV003911996
RCV003933812
RCV003934062
RCV003927355
RCV003959289
RCV003914620
RCV003934742
RCV003946951
RCV003979039
RCV003971558
RCV003920665
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Inhibit 27793380
Adenocarcinoma Associate 21670700
Adenoma Islet Cell Stimulate 30575306
Adenomyosis Associate 21067721
Adenomyosis Inhibit 30687738
Breast Neoplasms Associate 15044858, 22037257, 22439757, 27993161, 28748001
Breast Neoplasms Inhibit 9528762
Calcinosis Cutis Associate 35806108
Carcinogenesis Associate 23815210, 26097543, 37432996
Carcinoma Hepatocellular Associate 25120782, 33634306