Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3202
Gene name Gene Name - the full gene name approved by the HGNC.	Homeobox A5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HOXA5
Synonyms (NCBI Gene) Gene synonyms aliases	HOX1, HOX1.3, HOX1C
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7p15.2
Summary Summary of gene provided in NCBI Entrez Gene.	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic develo

Show/Hide all(197)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000958	hsa-miR-130a-3p	Luciferase reporter assay, qRT-PCR, Western blot, Northern blot	17957028
MIRT000958	hsa-miR-130a-3p	Review	19935707
MIRT001794	hsa-miR-19a-3p	Luciferase reporter assay	14697198
MIRT006906	hsa-miR-196a-5p	Luciferase reporter assay, qRT-PCR, Western blot	22876840
MIRT016043	hsa-miR-374b-5p	Sequencing	20371350
MIRT016627	hsa-miR-484	Sequencing	20371350
MIRT019581	hsa-miR-340-5p	Sequencing	20371350
MIRT020201	hsa-miR-130b-3p	Sequencing	20371350
MIRT000958	hsa-miR-130a-3p	Reporter assay;Other	17957028
MIRT025008	hsa-miR-183-5p	Sequencing	20371350
MIRT031182	hsa-miR-19b-3p	Sequencing	20371350
MIRT001794	hsa-miR-19a-3p	Reporter assay;Other	21271217
MIRT049277	hsa-miR-92a-3p	CLASH	23622248
MIRT320350	hsa-miR-200c-3p	qRT-PCR	23294929
MIRT320350	hsa-miR-200c-3p	qRT-PCR	23294929
MIRT025008	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT547915	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT547914	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT547913	hsa-miR-3666	PAR-CLIP	21572407
MIRT547912	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT547911	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT547910	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT020201	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT547909	hsa-miR-4295	PAR-CLIP	21572407
MIRT000958	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT547908	hsa-miR-8485	PAR-CLIP	21572407
MIRT258223	hsa-miR-5003-5p	PAR-CLIP	21572407
MIRT547907	hsa-miR-1909-5p	PAR-CLIP	21572407
MIRT547906	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT547905	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT547904	hsa-miR-4658	PAR-CLIP	21572407
MIRT547903	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT006906	hsa-miR-196a-5p	PAR-CLIP	23446348
MIRT513875	hsa-miR-196b-5p	PAR-CLIP	23446348
MIRT513873	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT513874	hsa-miR-3927-3p	PAR-CLIP	23446348
MIRT513872	hsa-miR-6831-5p	PAR-CLIP	23446348
MIRT513871	hsa-miR-6830-5p	PAR-CLIP	23446348
MIRT513870	hsa-miR-4457	PAR-CLIP	23446348
MIRT513868	hsa-miR-302b-5p	PAR-CLIP	23446348
MIRT513869	hsa-miR-302d-5p	PAR-CLIP	23446348
MIRT513867	hsa-miR-5585-3p	PAR-CLIP	23446348
MIRT734037	hsa-miR-891a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	33986868
MIRT025008	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT547915	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT547914	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT547913	hsa-miR-3666	PAR-CLIP	21572407
MIRT547912	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT547911	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT547910	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT020201	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT547909	hsa-miR-4295	PAR-CLIP	21572407
MIRT000958	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT547908	hsa-miR-8485	PAR-CLIP	21572407
MIRT258223	hsa-miR-5003-5p	PAR-CLIP	21572407
MIRT547907	hsa-miR-1909-5p	PAR-CLIP	21572407
MIRT547906	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT547905	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT547904	hsa-miR-4658	PAR-CLIP	21572407
MIRT547903	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT006906	hsa-miR-196a-5p	PAR-CLIP	23446348
MIRT513875	hsa-miR-196b-5p	PAR-CLIP	23446348
MIRT513873	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT513874	hsa-miR-3927-3p	PAR-CLIP	23446348
MIRT513872	hsa-miR-6831-5p	PAR-CLIP	23446348
MIRT513871	hsa-miR-6830-5p	PAR-CLIP	23446348
MIRT513870	hsa-miR-4457	PAR-CLIP	23446348
MIRT513868	hsa-miR-302b-5p	PAR-CLIP	23446348
MIRT513869	hsa-miR-302d-5p	PAR-CLIP	23446348
MIRT513867	hsa-miR-5585-3p	PAR-CLIP	23446348
MIRT1053201	hsa-miR-1271	CLIP-seq
MIRT1053202	hsa-miR-1278	CLIP-seq
MIRT1053203	hsa-miR-128	CLIP-seq
MIRT1053204	hsa-miR-129-5p	CLIP-seq
MIRT1053205	hsa-miR-1297	CLIP-seq
MIRT1053206	hsa-miR-1305	CLIP-seq
MIRT1053207	hsa-miR-130a	CLIP-seq
MIRT1053208	hsa-miR-130b	CLIP-seq
MIRT1053209	hsa-miR-196a	CLIP-seq
MIRT1053210	hsa-miR-196b	CLIP-seq
MIRT1053211	hsa-miR-200b	CLIP-seq
MIRT1053212	hsa-miR-200c	CLIP-seq
MIRT1053213	hsa-miR-26a	CLIP-seq
MIRT1053214	hsa-miR-26b	CLIP-seq
MIRT1053215	hsa-miR-27a	CLIP-seq
MIRT1053216	hsa-miR-27b	CLIP-seq
MIRT1053217	hsa-miR-301a	CLIP-seq
MIRT1053218	hsa-miR-301b	CLIP-seq
MIRT1053219	hsa-miR-3117-5p	CLIP-seq
MIRT1053220	hsa-miR-3179	CLIP-seq
MIRT1053221	hsa-miR-320a	CLIP-seq
MIRT1053222	hsa-miR-320b	CLIP-seq
MIRT1053223	hsa-miR-320c	CLIP-seq
MIRT1053224	hsa-miR-320d	CLIP-seq
MIRT1053225	hsa-miR-3682-5p	CLIP-seq
MIRT1053226	hsa-miR-382	CLIP-seq
MIRT1053227	hsa-miR-3927	CLIP-seq
MIRT1053228	hsa-miR-3941	CLIP-seq
MIRT1053229	hsa-miR-3977	CLIP-seq
MIRT1053230	hsa-miR-429	CLIP-seq
MIRT1053231	hsa-miR-4311	CLIP-seq
MIRT1053232	hsa-miR-4429	CLIP-seq
MIRT1053233	hsa-miR-4436a	CLIP-seq
MIRT1053234	hsa-miR-4438	CLIP-seq
MIRT1053235	hsa-miR-4465	CLIP-seq
MIRT1053236	hsa-miR-454	CLIP-seq
MIRT1053237	hsa-miR-4652-5p	CLIP-seq
MIRT1053238	hsa-miR-466	CLIP-seq
MIRT1053239	hsa-miR-4672	CLIP-seq
MIRT1053240	hsa-miR-4711-3p	CLIP-seq
MIRT1053241	hsa-miR-4713-3p	CLIP-seq
MIRT1053242	hsa-miR-4716-3p	CLIP-seq
MIRT1053243	hsa-miR-4720-3p	CLIP-seq
MIRT1053244	hsa-miR-4731-3p	CLIP-seq
MIRT1053245	hsa-miR-4789-5p	CLIP-seq
MIRT1053246	hsa-miR-4801	CLIP-seq
MIRT1053247	hsa-miR-4804-3p	CLIP-seq
MIRT1053248	hsa-miR-498	CLIP-seq
MIRT1053249	hsa-miR-5095	CLIP-seq
MIRT1053250	hsa-miR-548ac	CLIP-seq
MIRT1053251	hsa-miR-548ae	CLIP-seq
MIRT1053252	hsa-miR-548aj	CLIP-seq
MIRT1053253	hsa-miR-548am	CLIP-seq
MIRT1053254	hsa-miR-548d-3p	CLIP-seq
MIRT1053255	hsa-miR-548x	CLIP-seq
MIRT1053256	hsa-miR-548z	CLIP-seq
MIRT1053257	hsa-miR-592	CLIP-seq
MIRT1053258	hsa-miR-599	CLIP-seq
MIRT1053259	hsa-miR-802	CLIP-seq
MIRT1053260	hsa-miR-96	CLIP-seq
MIRT1053205	hsa-miR-1297	CLIP-seq
MIRT1053213	hsa-miR-26a	CLIP-seq
MIRT1053214	hsa-miR-26b	CLIP-seq
MIRT1053225	hsa-miR-3682-5p	CLIP-seq
MIRT1053229	hsa-miR-3977	CLIP-seq
MIRT1053235	hsa-miR-4465	CLIP-seq
MIRT1053259	hsa-miR-802	CLIP-seq
MIRT2012092	hsa-miR-124	CLIP-seq
MIRT1053202	hsa-miR-1278	CLIP-seq
MIRT1053203	hsa-miR-128	CLIP-seq
MIRT2012093	hsa-miR-1283	CLIP-seq
MIRT2012094	hsa-miR-1289	CLIP-seq
MIRT1053204	hsa-miR-129-5p	CLIP-seq
MIRT2012095	hsa-miR-142-5p	CLIP-seq
MIRT1053209	hsa-miR-196a	CLIP-seq
MIRT1053210	hsa-miR-196b	CLIP-seq
MIRT2012096	hsa-miR-19a	CLIP-seq
MIRT2012097	hsa-miR-19b	CLIP-seq
MIRT1053211	hsa-miR-200b	CLIP-seq
MIRT1053212	hsa-miR-200c	CLIP-seq
MIRT2012098	hsa-miR-224	CLIP-seq
MIRT1053215	hsa-miR-27a	CLIP-seq
MIRT1053216	hsa-miR-27b	CLIP-seq
MIRT1053219	hsa-miR-3117-5p	CLIP-seq
MIRT2012099	hsa-miR-3180-5p	CLIP-seq
MIRT2012100	hsa-miR-3198	CLIP-seq
MIRT2012101	hsa-miR-329	CLIP-seq
MIRT2012102	hsa-miR-337-3p	CLIP-seq
MIRT2012103	hsa-miR-340	CLIP-seq
MIRT2012104	hsa-miR-3622a-5p	CLIP-seq
MIRT2012105	hsa-miR-362-3p	CLIP-seq
MIRT1053227	hsa-miR-3927	CLIP-seq
MIRT1053230	hsa-miR-429	CLIP-seq
MIRT2012106	hsa-miR-4294	CLIP-seq
MIRT2012107	hsa-miR-4309	CLIP-seq
MIRT2012108	hsa-miR-432	CLIP-seq
MIRT2012109	hsa-miR-4328	CLIP-seq
MIRT2012110	hsa-miR-4484	CLIP-seq
MIRT1053241	hsa-miR-4713-3p	CLIP-seq
MIRT2012111	hsa-miR-4797-3p	CLIP-seq
MIRT2012112	hsa-miR-4797-5p	CLIP-seq
MIRT2012113	hsa-miR-506	CLIP-seq
MIRT2012114	hsa-miR-517a	CLIP-seq
MIRT2012115	hsa-miR-517b	CLIP-seq
MIRT2012116	hsa-miR-517c	CLIP-seq
MIRT2012117	hsa-miR-518a-5p	CLIP-seq
MIRT2012118	hsa-miR-520a-5p	CLIP-seq
MIRT2012119	hsa-miR-525-5p	CLIP-seq
MIRT2012120	hsa-miR-527	CLIP-seq
MIRT2012121	hsa-miR-548an	CLIP-seq
MIRT2012122	hsa-miR-574-3p	CLIP-seq
MIRT1053258	hsa-miR-599	CLIP-seq
MIRT2012123	hsa-miR-767-3p	CLIP-seq
MIRT2244364	hsa-miR-1252	CLIP-seq
MIRT1053215	hsa-miR-27a	CLIP-seq
MIRT1053216	hsa-miR-27b	CLIP-seq
MIRT2244365	hsa-miR-3942-3p	CLIP-seq
MIRT1053243	hsa-miR-4720-3p	CLIP-seq
MIRT1053244	hsa-miR-4731-3p	CLIP-seq
MIRT1053246	hsa-miR-4801	CLIP-seq
MIRT1053247	hsa-miR-4804-3p	CLIP-seq
MIRT2244366	hsa-miR-499a-5p	CLIP-seq
MIRT2244367	hsa-miR-890	CLIP-seq
MIRT1053204	hsa-miR-129-5p	CLIP-seq
MIRT2465447	hsa-miR-145	CLIP-seq
MIRT2465448	hsa-miR-375	CLIP-seq
MIRT2465449	hsa-miR-561	CLIP-seq

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10879542
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	10879542
GO:0003016	Process	Respiratory system process	IEA
GO:0003677	Function	DNA binding	IDA	8657138
GO:0003700	Function	DNA-binding transcription factor activity	IDA	10879542, 16756717
GO:0005515	Function	Protein binding	IPI	15545268, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	15545268
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0009952	Process	Anterior/posterior pattern specification	IBA	21873635
GO:0010628	Process	Positive regulation of gene expression	IDA	10875927
GO:0016477	Process	Cell migration	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IMP	17957028, 23136161
GO:0030878	Process	Thyroid gland development	IEA
GO:0033599	Process	Regulation of mammary gland epithelial cell proliferation	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	10879542
GO:0045639	Process	Positive regulation of myeloid cell differentiation	IDA	10397719
GO:0045647	Process	Negative regulation of erythrocyte differentiation	IDA	10397719
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	10879542, 16756717
GO:0048286	Process	Lung alveolus development	IEA
GO:0048704	Process	Embryonic skeletal system morphogenesis	IEA
GO:0060435	Process	Bronchiole development	IEA
GO:0060441	Process	Epithelial tube branching involved in lung morphogenesis	IEA
GO:0060480	Process	Lung goblet cell differentiation	IEA
GO:0060484	Process	Lung-associated mesenchyme development	IEA
GO:0060535	Process	Trachea cartilage morphogenesis	IEA
GO:0060574	Process	Intestinal epithelial cell maturation	IEA
GO:0060638	Process	Mesenchymal-epithelial cell signaling	IEA
GO:0060644	Process	Mammary gland epithelial cell differentiation	IEA
GO:0060749	Process	Mammary gland alveolus development	IEA
GO:0060764	Process	Cell-cell signaling involved in mammary gland development	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
142952	5106	ENSG00000106004

Protein

UniProt ID

P20719

Protein name

Homeobox protein Hox-A5 (Homeobox protein Hox-1C)

Protein function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	196 → 252	Homeodomain	Domain

Sequence

MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSG
SGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDSHHGGKN
SLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWM
RKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIK
IWFQNRRMKWKKDNKLKSMSMAAAGGAFRP

Sequence length

270

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Carcinoma of the head and neck	Squamous cell carcinoma of the head and neck	rs121909237, rs121909250, rs121909251, rs121909252, rs28934571, rs28934574, rs28934576, rs28934578, rs121912664, rs397516436, rs121912666, rs397514495, rs587782705, rs193920774, rs730882001 View all (7 more)	22227861

Show/Hide Text Mining Associations (65)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	26035298, 35370463
Adrenocortical Carcinoma	Inhibit	34027794
Alzheimer Disease	Associate	37038196, 40244264
Androgen Insensitivity Syndrome	Associate	21311178
Aneurysm Ascending Aorta	Associate	28935963
Arthritis Psoriatic	Associate	31701765
Arthritis Rheumatoid	Associate	36398888
Asthma	Associate	40349045
Astrocytoma	Associate	24650279
ATR X syndrome	Associate	37812190
Breast Neoplasms	Inhibit	10875927, 17167183
Breast Neoplasms	Associate	12819009, 14701762, 15545268, 15757903, 16756717, 27809618, 37595068
Carcinogenesis	Associate	15757903, 29532406, 31882852, 33136093, 33941222
Carcinoma Endometrioid	Associate	37834206
Carcinoma Intraductal Noninfiltrating	Associate	26249178
Carcinoma Non Small Cell Lung	Associate	22876840, 38346527, 40007122
Carcinoma Non Small Cell Lung	Inhibit	25549794
Carcinoma Renal Cell	Associate	36536414
CHARGE Syndrome	Associate	28475860
Cholangiocarcinoma	Associate	21876633
Colorectal Neoplasms	Associate	29532406, 33136093
Diabetes Mellitus Type 2	Associate	32041280, 35203377
Dissection Thoracic Aorta	Inhibit	34103071
Endometrial Neoplasms	Associate	31880256, 37834206
Endometriosis	Associate	33667269
Glioma	Associate	28055976, 37812190
Glioma	Stimulate	35349479
Gliosis	Associate	31779094
Hereditary Breast and Ovarian Cancer Syndrome	Associate	15545268, 16756717
Hodgkin Disease	Associate	21454882
Hyperlipoproteinemia Type II	Associate	32938406
Hyperplasia	Associate	36398888
Hypertrophy	Associate	35203377
Insulin Resistance	Associate	35836279
Intestinal Diseases	Inhibit	32736574
Kabuki syndrome	Associate	28475860
Leukemia	Associate	17785556
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	17785556, 32721103
Leukemia Myeloid	Associate	27052693
Leukemia Myeloid Acute	Associate	25987065, 27460741, 32614525
Leukemia Myeloid Acute	Stimulate	31426381
Leukemia T Cell	Associate	36017556
Liposarcoma	Inhibit	26219418
Lupus Erythematosus Systemic	Associate	40185033
Lymphatic Metastasis	Inhibit	25549794
Lymphatic Metastasis	Associate	33136093, 36454866
Lymphoma B Cell	Associate	21454882
Lymphoma Mantle Cell	Associate	21454882
Melanoma	Associate	29174371
Multiple Sclerosis	Associate	31779094
Neoplasm Metastasis	Associate	24103700, 32675397
Neoplasms	Associate	12819009, 16756717, 22227861, 23864708, 24674026, 25287138, 33136093, 37834206
Neoplasms	Inhibit	24004452, 25549794, 30940212, 31880256
Norrie disease	Associate	32041280
Obesity	Associate	24058506, 35203377
Osteosarcoma	Associate	32675397
Ovarian Neoplasms	Associate	33667269
Precursor Cell Lymphoblastic Leukemia Lymphoma	Stimulate	26846409
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	27460741, 32103106
Prostatic Neoplasms	Associate	31882852
Psoriasis	Associate	31701765
Purpura Thrombocytopenic Idiopathic	Associate	26846409
Renal Insufficiency Chronic	Associate	32930636
Squamous Cell Carcinoma of Head and Neck	Associate	22227861
Stomach Neoplasms	Associate	24674026, 32736574

HOXA5 (homeobox A5)