Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3195
Gene name	T cell leukemia homeobox 1
Gene symbol	TLX1
Synonyms (NCBI Gene)	HOX11TCL3
Chromosome	10
Chromosome location	10q24.31
Summary	This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specif

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019615	hsa-miR-340-5p	Sequencing	20371350
MIRT029889	hsa-miR-26b-5p	Microarray	19088304
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT665822	hsa-miR-4427	HITS-CLIP	23824327
MIRT665821	hsa-miR-5187-3p	HITS-CLIP	23824327
MIRT665820	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652566	hsa-miR-4780	HITS-CLIP	23824327
MIRT652564	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT652553	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT652552	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT652551	hsa-miR-8089	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652547	hsa-miR-3144-5p	HITS-CLIP	23824327
MIRT652546	hsa-miR-3191-3p	HITS-CLIP	23824327
MIRT652545	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652543	hsa-miR-623	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652540	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT665822	hsa-miR-4427	HITS-CLIP	23824327
MIRT665821	hsa-miR-5187-3p	HITS-CLIP	23824327
MIRT665820	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652566	hsa-miR-4780	HITS-CLIP	23824327
MIRT652564	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT652553	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT652552	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT652551	hsa-miR-8089	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652547	hsa-miR-3144-5p	HITS-CLIP	23824327
MIRT652546	hsa-miR-3191-3p	HITS-CLIP	23824327
MIRT652545	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652543	hsa-miR-623	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652540	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT2127952	hsa-miR-3154	CLIP-seq
MIRT2127953	hsa-miR-3179	CLIP-seq
MIRT2127954	hsa-miR-3919	CLIP-seq

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Transcription factor	Regulation	Reference
MYC	Unknown	20618946

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	19559479, 22516263, 35140242
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048513	Process	Animal organ development	IBA

MIM	HGNC	e!Ensembl
186770	5056	ENSG00000107807

P31314

Protein name

T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)

Protein function

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	202 → 258	Homeodomain	Domain

Sequence

MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG
GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS
GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN
RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM
TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN
SSLFALQNLQPWSDDSTKITSVTSVASACE

Sequence length

330

Interactions

View interactions

	KEGG
	Transcriptional misregulation in cancer

TLX1 (T cell leukemia homeobox 1)