Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3195
Gene name Gene Name - the full gene name approved by the HGNC.	T cell leukemia homeobox 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TLX1
Synonyms (NCBI Gene) Gene synonyms aliases	HOX11, TCL3
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q24.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specif

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019615	hsa-miR-340-5p	Sequencing	20371350
MIRT029889	hsa-miR-26b-5p	Microarray	19088304
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT665822	hsa-miR-4427	HITS-CLIP	23824327
MIRT665821	hsa-miR-5187-3p	HITS-CLIP	23824327
MIRT665820	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652566	hsa-miR-4780	HITS-CLIP	23824327
MIRT652564	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT652553	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT652552	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT652551	hsa-miR-8089	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652547	hsa-miR-3144-5p	HITS-CLIP	23824327
MIRT652546	hsa-miR-3191-3p	HITS-CLIP	23824327
MIRT652545	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652543	hsa-miR-623	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652540	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT665822	hsa-miR-4427	HITS-CLIP	23824327
MIRT665821	hsa-miR-5187-3p	HITS-CLIP	23824327
MIRT665820	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT652566	hsa-miR-4780	HITS-CLIP	23824327
MIRT652564	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT652563	hsa-miR-5193	HITS-CLIP	23824327
MIRT652562	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT652561	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT652560	hsa-miR-4287	HITS-CLIP	23824327
MIRT652559	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT652558	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT652557	hsa-miR-301a-5p	HITS-CLIP	23824327
MIRT652556	hsa-miR-301b-5p	HITS-CLIP	23824327
MIRT652555	hsa-miR-3921	HITS-CLIP	23824327
MIRT652554	hsa-miR-4653-5p	HITS-CLIP	23824327
MIRT652553	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT652552	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT652551	hsa-miR-8089	HITS-CLIP	23824327
MIRT652550	hsa-miR-3928-5p	HITS-CLIP	23824327
MIRT652549	hsa-miR-6806-3p	HITS-CLIP	23824327
MIRT652548	hsa-miR-4268	HITS-CLIP	23824327
MIRT652547	hsa-miR-3144-5p	HITS-CLIP	23824327
MIRT652546	hsa-miR-3191-3p	HITS-CLIP	23824327
MIRT652545	hsa-miR-4652-5p	HITS-CLIP	23824327
MIRT652544	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT652543	hsa-miR-623	HITS-CLIP	23824327
MIRT652542	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT652541	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT652540	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT652539	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652538	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652537	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT2127952	hsa-miR-3154	CLIP-seq
MIRT2127953	hsa-miR-3179	CLIP-seq
MIRT2127954	hsa-miR-3919	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
MYC	Unknown	20618946

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0005515	Function	Protein binding	IPI	19559479, 22516263
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048513	Process	Animal organ development	IBA	21873635

MIM	HGNC	e!Ensembl
186770	5056	ENSG00000107807

Protein

UniProt ID

P31314

Protein name

T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)

Protein function

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	202 → 258	Homeodomain	Domain

Sequence

MEHLGPHHLHPGHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGG
GSAAATGAGGAGAYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGGGGGSS
GGAGALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAMPGVNNLTGLTFPWMESN
RRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKM
TDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILLQLQQEAFQKSLAQPLPADPLCVHN
SSLFALQNLQPWSDDSTKITSVTSVASACE

Sequence length

330

Interactions

View interactions

	KEGG
	Transcriptional misregulation in cancer

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Lymphoblastic leukemia	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-cell acute lymphoblastic leukemia	rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699 View all (13 more)	22516263, 20972433, 22516255

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining
Ataxia Telangiectasia	Associate	12086890, 17609427
Breast Neoplasms	Associate	19250546
Colorectal Neoplasms	Associate	28351398
Familial paroxysmal dystonia	Associate	1717256
Glioblastoma	Associate	34238116
Leukemia	Associate	12086890, 1717256, 22366949
Leukemia Biphenotypic Acute	Associate	32488880
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	24886876
Leukemia T Cell	Associate	1717256
Lymphoma	Associate	39984035
Lymphoma T Cell	Associate	1717256, 35562412
Neoplasms	Associate	2326274, 23637834, 28351398
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	15054041, 22516263, 28671688, 32488880
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	15713800, 15774621, 1717256, 17609427, 18492690, 19494353, 19835636, 20618946, 22366949, 2326274, 24367274, 2542965, 28151996, 29746601, 32142900 View all (4 more)
Stomach Neoplasms	Associate	30106137

TLX1 (T cell leukemia homeobox 1)