KRT73 (keratin 73)

Gene

• Entrez ID: 319101
• Gene name: Keratin 73
• Gene symbol: KRT73
• Synonyms (NCBI Gene): CK-73, IRT6IRS3, K6IRS3, K73, KRT6IRS3
• Chromosome: 12
• Chromosome location: 12q13.13
• Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicle

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1101453	hsa-miR-1224-5p	CLIP-seq
MIRT1101454	hsa-miR-137	CLIP-seq
MIRT1101455	hsa-miR-143	CLIP-seq
MIRT1101456	hsa-miR-1827	CLIP-seq
MIRT1101457	hsa-miR-4428	CLIP-seq
MIRT1101458	hsa-miR-4499	CLIP-seq
MIRT1101459	hsa-miR-4649-3p	CLIP-seq
MIRT1101460	hsa-miR-4712-3p	CLIP-seq
MIRT1101461	hsa-miR-4751	CLIP-seq
MIRT1101462	hsa-miR-4770	CLIP-seq
MIRT1101463	hsa-miR-495	CLIP-seq
MIRT1101464	hsa-miR-548u	CLIP-seq
MIRT2027581	hsa-miR-3170	CLIP-seq
MIRT2027582	hsa-miR-4514	CLIP-seq
MIRT2027583	hsa-miR-4692	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0031424	Process	Keratinization	IBA
GO:0045095	Component	Keratin filament	IBA
GO:0045095	Component	Keratin filament	IEA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0070062	Component	Extracellular exosome	HDA	19199708, 23533145

Other IDs

• MIM: 608247
• HGNC: 28928
• e!Ensembl: ENSG00000186049

Protein

• UniProt ID: Q86Y46
• Protein name: Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)
• Protein function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16208	Keratin_2_head	62 → 128	Keratin type II head	Family
  PF00038	Filament	131 → 444	Intermediate filament protein	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is
• Sequence:

  MSRQFTYKSGAAAKGGFSGCSAVLSGGSSSSYRAGGKGLSGGFSSRSLYSLGGARSISFN
  VASGSGWAGGYGFGRGRASGFAGSMFGSVALGSVCPSLCPPGGIHQVTINKSLLAPLNVE
  LDPEIQKVRAQEREQIKVLNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLE
  PILEGYISNLRKQLETLSGDRVRLDSELRSVREVVEDYKKRYEEEINKRTTAENEFVVLK
  KDVDAAYTSKVELQAKVDALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLD
  SIIAEVRAQYEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRL
  RSEIESVKKQCANLETAIADAEQRGDCALKDARAKLDELEGALQQAKEELARMLREYQEL
  LSVKLSLDIEIATYRKLLEGEECRMSGEYTNSVSISVINSSMAGMAGTGAGFGFSNAGTY
  GYWPSSVSGGYSMLPGGCVTGSGNCSPRGEARTRLGSASEFRDSQGKTLALSSPTKKTMR
  

• Sequence length: 540

Pathways

Reactome:

Keratinization
Formation of the cornified envelope