Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3191
Gene name Gene Name - the full gene name approved by the HGNC.	Heterogeneous nuclear ribonucleoprotein L
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HNRNPL
Synonyms (NCBI Gene) Gene synonyms aliases	HNRPL, P/OKcl.14, hnRNP-L
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are sta

Show/Hide all(133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016285	hsa-miR-193b-3p	Proteomics	21512034
MIRT025002	hsa-miR-183-5p	Sequencing	20371350
MIRT051924	hsa-let-7b-5p	CLASH	23622248
MIRT051122	hsa-miR-16-5p	CLASH	23622248
MIRT051122	hsa-miR-16-5p	CLASH	23622248
MIRT046364	hsa-miR-23b-3p	CLASH	23622248
MIRT045182	hsa-miR-186-5p	CLASH	23622248
MIRT044366	hsa-miR-106b-5p	CLASH	23622248
MIRT043796	hsa-miR-328-3p	CLASH	23622248
MIRT043110	hsa-miR-324-5p	CLASH	23622248
MIRT039633	hsa-miR-615-3p	CLASH	23622248
MIRT036902	hsa-miR-877-3p	CLASH	23622248
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT567289	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT567288	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT567287	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT567286	hsa-miR-4738-5p	PAR-CLIP	20371350
MIRT567285	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT567284	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567283	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT567282	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT567281	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT567280	hsa-miR-587	PAR-CLIP	20371350
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT732831	hsa-miR-30a-3p	Immunofluorescence, Luciferase reporter assay, RNA-seq, Western blotting	33397440
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT567289	hsa-miR-7109-3p	PAR-CLIP	20371350
MIRT567288	hsa-miR-6819-3p	PAR-CLIP	20371350
MIRT567287	hsa-miR-6877-3p	PAR-CLIP	20371350
MIRT567286	hsa-miR-4738-5p	PAR-CLIP	20371350
MIRT567285	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT567284	hsa-miR-6854-3p	PAR-CLIP	20371350
MIRT567283	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT567282	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT567281	hsa-miR-3180-5p	PAR-CLIP	20371350
MIRT567280	hsa-miR-587	PAR-CLIP	20371350
MIRT562177	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT562178	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT562175	hsa-miR-4719	PAR-CLIP	20371350
MIRT562176	hsa-miR-6721-5p	PAR-CLIP	20371350
MIRT1051839	hsa-miR-1227	CLIP-seq
MIRT1051840	hsa-miR-1283	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT1051845	hsa-miR-338-5p	CLIP-seq
MIRT1051846	hsa-miR-3609	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051851	hsa-miR-4480	CLIP-seq
MIRT1051852	hsa-miR-455-5p	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT1051855	hsa-miR-4717-3p	CLIP-seq
MIRT1051856	hsa-miR-4775	CLIP-seq
MIRT1051857	hsa-miR-493	CLIP-seq
MIRT1051858	hsa-miR-548ah	CLIP-seq
MIRT1051859	hsa-miR-548c-3p	CLIP-seq
MIRT1051860	hsa-miR-548n	CLIP-seq
MIRT1051861	hsa-miR-548t	CLIP-seq
MIRT1051862	hsa-miR-590-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT1051839	hsa-miR-1227	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051864	hsa-miR-203	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT1051865	hsa-miR-3148	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT1051846	hsa-miR-3609	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051851	hsa-miR-4480	CLIP-seq
MIRT1051852	hsa-miR-455-5p	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT1051857	hsa-miR-493	CLIP-seq
MIRT1051858	hsa-miR-548ah	CLIP-seq
MIRT1051861	hsa-miR-548t	CLIP-seq
MIRT1051862	hsa-miR-590-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT1051839	hsa-miR-1227	CLIP-seq
MIRT2244048	hsa-miR-1236	CLIP-seq
MIRT2244049	hsa-miR-1245b-3p	CLIP-seq
MIRT1051841	hsa-miR-132	CLIP-seq
MIRT1051842	hsa-miR-1470	CLIP-seq
MIRT1051864	hsa-miR-203	CLIP-seq
MIRT1051843	hsa-miR-212	CLIP-seq
MIRT2244050	hsa-miR-3074-5p	CLIP-seq
MIRT1051844	hsa-miR-3158-5p	CLIP-seq
MIRT2244051	hsa-miR-3199	CLIP-seq
MIRT2244052	hsa-miR-3622a-5p	CLIP-seq
MIRT1051847	hsa-miR-3689a-3p	CLIP-seq
MIRT1051848	hsa-miR-3689c	CLIP-seq
MIRT2244053	hsa-miR-370	CLIP-seq
MIRT2244054	hsa-miR-384	CLIP-seq
MIRT1051849	hsa-miR-4287	CLIP-seq
MIRT2244055	hsa-miR-4330	CLIP-seq
MIRT2244056	hsa-miR-4423-3p	CLIP-seq
MIRT1051850	hsa-miR-4469	CLIP-seq
MIRT1051851	hsa-miR-4480	CLIP-seq
MIRT1051852	hsa-miR-455-5p	CLIP-seq
MIRT1051853	hsa-miR-4667-3p	CLIP-seq
MIRT1051854	hsa-miR-4685-3p	CLIP-seq
MIRT2244057	hsa-miR-539	CLIP-seq
MIRT1051862	hsa-miR-590-3p	CLIP-seq
MIRT1051863	hsa-miR-635	CLIP-seq
MIRT2244058	hsa-miR-767-3p	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IEA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IMP	25623890
GO:0000785	Component	Chromatin	IDA	33174841
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	11809897
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	2687284
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	11809897, 18669861, 23976881, 26979993, 33174841, 35271311, 36537238
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15798186, 33174841
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	2687284
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS	2687284
GO:0005737	Component	Cytoplasm	IDA	33174841
GO:0005737	Component	Cytoplasm	IEA
GO:0006396	Process	RNA processing	TAS	2687284
GO:0006397	Process	MRNA processing	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0035770	Component	Ribonucleoprotein granule	IDA	17289661
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0043484	Process	Regulation of RNA splicing	IEA
GO:0045120	Component	Pronucleus	IEA
GO:0045202	Component	Synapse	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	33174841
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097157	Function	Pre-mRNA intronic binding	IDA	25623890
GO:1990904	Component	Ribonucleoprotein complex	IDA	2687284, 17289661, 33174841
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603083	5045	ENSG00000104824

Protein

UniProt ID

P14866

Protein name

Heterogeneous nuclear ribonucleoprotein L (hnRNP L)

Protein function

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:

PDB

3R27 , 3TO8 , 7EVR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	104 → 162	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF11835	RRM_8	184 → 270	RRM-like domain	Domain
PF13893	RRM_5	356 → 480		Domain

Sequence

MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKR
LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVE
ALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKIS
RPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDS
VQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNP
NKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYG
PQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPG
AAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSES
RNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSE
RSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS

Sequence length

589

Interactions

View interactions

	Reactome
			mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Neurodevelopmental Disorders	complex neurodevelopmental disorder	N/A	N/A	GenCC
Prostate cancer	Prostate cancer	HNRNPL Is Required for Prostate Cancer Cell Growth.	28611215	CBGDA

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adrenocortical Carcinoma	Associate	32915499
Amyotrophic Lateral Sclerosis	Associate	36930682
Autoimmune Diseases	Associate	21507955
Brain Diseases	Associate	29484035
Carcinogenesis	Associate	20972326, 28088793, 28520992, 31828152
Carcinoma Non Small Cell Lung	Associate	20972326, 28296343
Carcinoma Pancreatic Ductal	Associate	34779408
Cerebral Palsy	Associate	29484035
Colorectal Neoplasms	Associate	31320608
Endometrial Neoplasms	Associate	32915499
Esophageal Squamous Cell Carcinoma	Associate	35982900
Frontotemporal Dementia	Associate	36930682
Hypoxia	Associate	28520992
Leukemia Myeloid Acute	Associate	29908545
Lymphoma B Cell	Associate	30530525
Malformations of Cortical Development Group I	Associate	28381165
Neoplasm Metastasis	Associate	33542227
Neoplasms	Associate	28088793, 30530525, 31138119, 31828152
Pancreatic Neoplasms	Associate	31355266
Personality Disorders	Stimulate	31355266
Prostatic Neoplasms	Associate	28611215, 33542227
Prostatitis	Associate	28611215
Purpura Thrombocytopenic Idiopathic	Associate	32563217
Sarcoma Ewing	Associate	34662337
Squamous Cell Carcinoma of Head and Neck	Associate	31828152
Stomach Neoplasms	Associate	26805816
Thymoma	Associate	32915499
Urinary Bladder Neoplasms	Associate	28088793

HNRNPL (heterogeneous nuclear ribonucleoprotein L)