Gene Gene information from NCBI Gene database.
Entrez ID 317762
Gene name Coiled-coil domain containing 85C
Gene symbol CCDC85C
Synonyms (NCBI Gene)
-
Chromosome 14
Chromosome location 14q32.2
miRNA miRNA information provided by mirtarbase database.
777
miRTarBase ID miRNA Experiments Reference
MIRT613222 hsa-miR-135a-5p HITS-CLIP 19536157
MIRT613221 hsa-miR-135b-5p HITS-CLIP 19536157
MIRT613220 hsa-miR-4270 HITS-CLIP 19536157
MIRT613219 hsa-miR-4441 HITS-CLIP 19536157
MIRT613218 hsa-miR-6754-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 38185225
GO:0005912 Component Adherens junction IDA 25009281
GO:0005912 Component Adherens junction IEA
GO:0005923 Component Bicellular tight junction IEA
GO:0007219 Process Notch signaling pathway IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
621283 35459 ENSG00000205476
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A6NKD9
Protein name Coiled-coil domain-containing protein 85C
Protein function May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By si
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10226 CCDC85 12 219 CCDC85 family Family
Sequence
MAKPAATAAAASEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRL
QQHLLEIRGLKDVNQRLQDDNQELRELCCFLDDDRQKGRKLAREWQRFGRHAAGAVWHEV
ARSQQKLRELEARQEALLRENLELKELVLLLDEERAALAATGAASGGGGGGGGAGSRSSI
DSQASLSGPLSGGAPGAGARDVGDGSSTSSAGSGGSPDH
HHHVPPPLLPPGPHKAPDGKA
GATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRQLESKVRLLEGDKLLAQQAGSGEFRTLR
KGFSPYHSESQLASLPPSYQDSLQNGPACPAPELPSPPSAGYSPAGQKPEAVVHAMKVLE
VHENLDRQLQDSCEEDLSEKEKAIVREMCNVVWRKLGDAASSKPSIRQHLSGNQFKGPL
Sequence length 419
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER WITH HYPERTELORISM AND DISTINCTIVE FACIES Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Alzheimer Disease Associate 25649651
★★☆☆☆
Found in Text Mining + Unknown/Other Associations