Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3161
Gene name Gene Name - the full gene name approved by the HGNC.	Hyaluronan mediated motility receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HMMR
Synonyms (NCBI Gene) Gene synonyms aliases	CD168, IHABP, RHAMM
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q34
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spli

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024628	hsa-miR-215-5p	Microarray	19074876
MIRT026177	hsa-miR-192-5p	Microarray	19074876
MIRT027466	hsa-miR-98-5p	Microarray	19088304
MIRT044370	hsa-miR-106b-5p	CLASH	23622248
MIRT038799	hsa-miR-93-3p	CLASH	23622248
MIRT733825	hsa-miR-411-5p	Luciferase reporter assay, qRT-PCR, Western blotting	32782498
MIRT1050086	hsa-miR-4484	CLIP-seq
MIRT1050087	hsa-miR-4753-5p	CLIP-seq
MIRT1050088	hsa-miR-548an	CLIP-seq
MIRT1050089	hsa-miR-4792	CLIP-seq
MIRT1050090	hsa-miR-548m	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050094	hsa-miR-3120-3p	CLIP-seq
MIRT1050095	hsa-miR-3121-3p	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050098	hsa-miR-3607-3p	CLIP-seq
MIRT1050099	hsa-miR-3671	CLIP-seq
MIRT1050100	hsa-miR-369-3p	CLIP-seq
MIRT1050101	hsa-miR-374a	CLIP-seq
MIRT1050102	hsa-miR-374b	CLIP-seq
MIRT1050103	hsa-miR-3920	CLIP-seq
MIRT1050104	hsa-miR-3976	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050106	hsa-miR-4477a	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT1050110	hsa-miR-4670-3p	CLIP-seq
MIRT1050111	hsa-miR-548c-3p	CLIP-seq
MIRT1050112	hsa-miR-660	CLIP-seq
MIRT1050113	hsa-miR-9	CLIP-seq
MIRT1050114	hsa-miR-944	CLIP-seq
MIRT1050115	hsa-miR-1185	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050116	hsa-miR-3163	CLIP-seq
MIRT1050117	hsa-miR-3185	CLIP-seq
MIRT1050118	hsa-miR-340	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050099	hsa-miR-3671	CLIP-seq
MIRT1050119	hsa-miR-3679-5p	CLIP-seq
MIRT1050120	hsa-miR-3942-3p	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050121	hsa-miR-4459	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT1050122	hsa-miR-4528	CLIP-seq
MIRT1050123	hsa-miR-4667-5p	CLIP-seq
MIRT1050124	hsa-miR-4700-5p	CLIP-seq
MIRT1050125	hsa-miR-4773	CLIP-seq
MIRT1050126	hsa-miR-637	CLIP-seq
MIRT1050112	hsa-miR-660	CLIP-seq
MIRT1050127	hsa-miR-665	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050094	hsa-miR-3120-3p	CLIP-seq
MIRT2243700	hsa-miR-3162-5p	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050100	hsa-miR-369-3p	CLIP-seq
MIRT1050101	hsa-miR-374a	CLIP-seq
MIRT1050102	hsa-miR-374b	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT2243701	hsa-miR-4666-5p	CLIP-seq
MIRT1050089	hsa-miR-4792	CLIP-seq
MIRT1050090	hsa-miR-548m	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT2451278	hsa-miR-1273f	CLIP-seq
MIRT2451279	hsa-miR-143	CLIP-seq
MIRT2451280	hsa-miR-320e	CLIP-seq
MIRT2451281	hsa-miR-4263	CLIP-seq
MIRT2451282	hsa-miR-4708-5p	CLIP-seq
MIRT2451283	hsa-miR-4770	CLIP-seq
MIRT2451284	hsa-miR-586	CLIP-seq
MIRT2451285	hsa-miR-875-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
AR	Unknown	18174258

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22110403, 22666460, 22965910, 25416956, 29789297, 31515488, 32296183, 32814053, 33961781, 35156780, 36012204
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005737	Component	Cytoplasm	IDA	31429579
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005819	Component	Spindle	IDA	31338967
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006898	Process	Receptor-mediated endocytosis	IEA
GO:0009986	Component	Cell surface	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016020	Component	Membrane	HDA	19946888
GO:0030214	Process	Hyaluronan catabolic process	IEA
GO:0038024	Function	Cargo receptor activity	IEA

MIM	HGNC	e!Ensembl
600936	5012	ENSG00000072571

Protein

UniProt ID

O75330

Protein name

Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)

Protein function

Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15905	HMMR_N	15 → 339	Hyaluronan mediated motility receptor N-terminal	Coiled-coil
PF15908	HMMR_C	552 → 708	Hyaluronan mediated motility receptor C-terminal	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751). {ECO:0000269|PubMed:22965910, ECO:0000269|PubMed:8890751}.

Sequence

MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLN
AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK
MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI
SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK
EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL
CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL
KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL
QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL
QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF
EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC
QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ
ESWK

Sequence length

724

Interactions

View interactions

	KEGG		Reactome
	ECM-receptor interaction		Hyaluronan uptake and degradation AURKA Activation by TPX2

HMMR (hyaluronan mediated motility receptor)