Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3161
Gene name	Hyaluronan mediated motility receptor
Gene symbol	HMMR
Synonyms (NCBI Gene)	CD168IHABPRHAMM
Chromosome	5
Chromosome location	5q34
Summary	The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spli

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024628	hsa-miR-215-5p	Microarray	19074876
MIRT026177	hsa-miR-192-5p	Microarray	19074876
MIRT027466	hsa-miR-98-5p	Microarray	19088304
MIRT044370	hsa-miR-106b-5p	CLASH	23622248
MIRT038799	hsa-miR-93-3p	CLASH	23622248
MIRT733825	hsa-miR-411-5p	Luciferase reporter assayqRT-PCRWestern blotting	32782498
MIRT1050086	hsa-miR-4484	CLIP-seq
MIRT1050087	hsa-miR-4753-5p	CLIP-seq
MIRT1050088	hsa-miR-548an	CLIP-seq
MIRT1050089	hsa-miR-4792	CLIP-seq
MIRT1050090	hsa-miR-548m	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050094	hsa-miR-3120-3p	CLIP-seq
MIRT1050095	hsa-miR-3121-3p	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050098	hsa-miR-3607-3p	CLIP-seq
MIRT1050099	hsa-miR-3671	CLIP-seq
MIRT1050100	hsa-miR-369-3p	CLIP-seq
MIRT1050101	hsa-miR-374a	CLIP-seq
MIRT1050102	hsa-miR-374b	CLIP-seq
MIRT1050103	hsa-miR-3920	CLIP-seq
MIRT1050104	hsa-miR-3976	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050106	hsa-miR-4477a	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT1050110	hsa-miR-4670-3p	CLIP-seq
MIRT1050111	hsa-miR-548c-3p	CLIP-seq
MIRT1050112	hsa-miR-660	CLIP-seq
MIRT1050113	hsa-miR-9	CLIP-seq
MIRT1050114	hsa-miR-944	CLIP-seq
MIRT1050115	hsa-miR-1185	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050116	hsa-miR-3163	CLIP-seq
MIRT1050117	hsa-miR-3185	CLIP-seq
MIRT1050118	hsa-miR-340	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050099	hsa-miR-3671	CLIP-seq
MIRT1050119	hsa-miR-3679-5p	CLIP-seq
MIRT1050120	hsa-miR-3942-3p	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050121	hsa-miR-4459	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT1050122	hsa-miR-4528	CLIP-seq
MIRT1050123	hsa-miR-4667-5p	CLIP-seq
MIRT1050124	hsa-miR-4700-5p	CLIP-seq
MIRT1050125	hsa-miR-4773	CLIP-seq
MIRT1050126	hsa-miR-637	CLIP-seq
MIRT1050112	hsa-miR-660	CLIP-seq
MIRT1050127	hsa-miR-665	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050094	hsa-miR-3120-3p	CLIP-seq
MIRT2243700	hsa-miR-3162-5p	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050100	hsa-miR-369-3p	CLIP-seq
MIRT1050101	hsa-miR-374a	CLIP-seq
MIRT1050102	hsa-miR-374b	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT2243701	hsa-miR-4666-5p	CLIP-seq
MIRT1050089	hsa-miR-4792	CLIP-seq
MIRT1050090	hsa-miR-548m	CLIP-seq
MIRT1050091	hsa-miR-23a	CLIP-seq
MIRT1050092	hsa-miR-23b	CLIP-seq
MIRT1050093	hsa-miR-23c	CLIP-seq
MIRT1050096	hsa-miR-34a	CLIP-seq
MIRT1050097	hsa-miR-34c-5p	CLIP-seq
MIRT1050105	hsa-miR-4326	CLIP-seq
MIRT1050107	hsa-miR-4477b	CLIP-seq
MIRT1050108	hsa-miR-449a	CLIP-seq
MIRT1050109	hsa-miR-449b	CLIP-seq
MIRT2451278	hsa-miR-1273f	CLIP-seq
MIRT2451279	hsa-miR-143	CLIP-seq
MIRT2451280	hsa-miR-320e	CLIP-seq
MIRT2451281	hsa-miR-4263	CLIP-seq
MIRT2451282	hsa-miR-4708-5p	CLIP-seq
MIRT2451283	hsa-miR-4770	CLIP-seq
MIRT2451284	hsa-miR-586	CLIP-seq
MIRT2451285	hsa-miR-875-3p	CLIP-seq

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Transcription factor	Regulation	Reference
AR	Unknown	18174258

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22110403, 22666460, 22965910, 25416956, 29789297, 31515488, 32296183, 32814053, 33961781, 35156780, 36012204
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005737	Component	Cytoplasm	IDA	31429579
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005819	Component	Spindle	IDA	31338967
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006898	Process	Receptor-mediated endocytosis	IEA
GO:0009986	Component	Cell surface	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016020	Component	Membrane	HDA	19946888
GO:0030214	Process	Hyaluronan catabolic process	IEA
GO:0038024	Function	Cargo receptor activity	IEA

MIM	HGNC	e!Ensembl
600936	5012	ENSG00000072571

O75330

Protein name

Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)

Protein function

Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15905	HMMR_N	15 → 339	Hyaluronan mediated motility receptor N-terminal	Coiled-coil
PF15908	HMMR_C	552 → 708	Hyaluronan mediated motility receptor C-terminal	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751). {ECO:0000269|PubMed:22965910, ECO:0000269|PubMed:8890751}.

Sequence

MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLN
AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK
MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI
SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK
EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL
CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL
KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL
QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL
QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF
EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC
QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ
ESWK

Sequence length

724

Interactions

View interactions

	KEGG		Reactome
	ECM-receptor interaction		Hyaluronan uptake and degradation AURKA Activation by TPX2

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Ovarian cancer	Likely pathogenic	rs780743612	RCV003154732

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Breast cancer, susceptibility to	Uncertain significance	rs199569126	RCV002244281
Familial cancer of breast	Uncertain significance	rs779902788, rs1452732844, rs777330187, rs374532508	RCV002465053 RCV003142291 RCV003337946 RCV001197341

Show/Hide Text Mining Associations (55)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	33234735
Adenocarcinoma of Lung	Associate	30727821, 33187219, 34304612, 35810236, 36311801
Adenoma Oxyphilic	Associate	21887686
Bone Diseases	Stimulate	15105292
Breast Neoplasms	Associate	17392272, 22110403, 25830658, 28595038, 32705365, 33959662, 35577044, 36726984, 36930083, 37186300, 37713876
Calcinosis	Stimulate	34983451
Carcinogenesis	Associate	33849532, 35403252
Carcinoma Hepatocellular	Associate	31822116, 33540684, 33688500, 33784984, 34187556
Carcinoma Non Small Cell Lung	Associate	26439031, 29532892
Carcinoma Papillary	Stimulate	21887686
Carcinoma Papillary	Associate	31568988
Carcinoma Renal Cell	Stimulate	21887686
Carcinoma Squamous Cell	Associate	36938730
Carcinosarcoma	Stimulate	34111996
Colorectal Neoplasms	Associate	12384809, 16763611, 34051513
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	16763611
Crohn Disease	Associate	10029598
Cysts	Associate	28954627
Disease	Stimulate	19724689
Endometrial Neoplasms	Associate	12712331
Fibrosarcoma	Associate	21914806
Glioblastoma	Associate	29574252, 30497369
Glioma	Associate	28161812, 36750807
Hearing Loss	Associate	36656851
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25830658
Kidney Neoplasms	Associate	33287763
Leukemia	Associate	19724689, 22719778
Leukemia Hairy Cell	Associate	7678518
Leukemia Lymphocytic Chronic B Cell	Associate	19561536
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	17157168
Leukemia Myeloid Acute	Associate	15627212, 19724689, 22719778, 27659531
Leukocyte adhesion deficiency type 1	Associate	27659531
Lung Neoplasms	Associate	32831194, 37910672
Lupus Erythematosus Systemic	Associate	36726984
Lymphatic Metastasis	Associate	12712331
Mesothelioma Malignant	Associate	33849532
Mouth Neoplasms	Associate	36052378
Multiple Myeloma	Associate	10029598, 15105292, 17213289, 36737429
Multiple Myeloma	Stimulate	7678518
Myelodysplastic Syndromes	Associate	22719778
Neoplasm Metastasis	Associate	12712331, 18172264, 21435222, 24966934, 31847905, 33269813, 34051513
Neoplasm Metastasis	Stimulate	19724689
Neoplasms	Associate	12384809, 12712331, 16763611, 17392272, 20960509, 21435222, 21887686, 22970268, 24966934, 28161812, 28595038, 31568988, 34051513, 34187556, 34556750, 35577044, 37186300, 37713876 View all (3 more)
Neurofibrosarcoma	Associate	15255999
Non Muscle Invasive Bladder Neoplasms	Associate	31568988
Ovarian Neoplasms	Associate	23824740, 28591191, 28954627
Personality Disorders	Associate	15105292
Primary Ovarian Insufficiency	Associate	36732629
Prostate Cancer Hereditary 7	Associate	24708576
Prostatic Neoplasms	Associate	19724689, 26456171
Squamous Cell Carcinoma of Head and Neck	Associate	35232899, 39323031
Stomach Neoplasms	Associate	21435222
Tachycardia Atrioventricular Nodal Reentry	Stimulate	21435222
Urinary Bladder Neoplasms	Associate	20960509, 27595989
Uterine Cervical Neoplasms	Associate	24966934

HMMR (hyaluronan mediated motility receptor)