Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3149
Gene name Gene Name - the full gene name approved by the HGNC.
High mobility group box 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HMGB3
Synonyms (NCBI Gene) Gene synonyms aliases
HMG-2a, HMG-4, HMG2A, HMG4
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq28
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs431825172 ->TA Not-provided, pathogenic Frameshift variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018990 hsa-miR-335-5p Microarray 18185580
MIRT019470 hsa-miR-148b-3p Microarray 17612493
MIRT031042 hsa-miR-21-5p Microarray 18591254
MIRT046106 hsa-miR-124-3p CLASH 23622248
MIRT037218 hsa-miR-877-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000400 Function Four-way junction DNA binding ISS
GO:0002376 Process Immune system process IEA
GO:0003677 Function DNA binding IEA
GO:0003690 Function Double-stranded DNA binding ISS
GO:0003723 Function RNA binding HDA 22681889
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
300193 5004 ENSG00000029993
Protein
UniProt ID O15347
Protein name High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)
Protein function Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend
PDB 2EQZ , 2YQI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09011 HMG_box_2 6 79 HMG-box domain Domain
PF00505 HMG_box 93 161 HMG (high mobility group) box Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in placenta.
Sequence
Sequence length 200
Interactions View interactions
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