HMGB3 (high mobility group box 3)

Gene

• Entrez ID: 3149
• Gene name: High mobility group box 3
• Gene symbol: HMGB3
• Synonyms (NCBI Gene): HMG-2a, HMG-4, HMG2A, HMG4
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs431825172	->TA	Not-provided, pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018990	hsa-miR-335-5p	Microarray	18185580
MIRT019470	hsa-miR-148b-3p	Microarray	17612493
MIRT031042	hsa-miR-21-5p	Microarray	18591254
MIRT046106	hsa-miR-124-3p	CLASH	23622248
MIRT037218	hsa-miR-877-5p	CLASH	23622248
MIRT054134	hsa-miR-513b-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	25095979
MIRT054134	hsa-miR-513b-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	25095979
MIRT437429	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	24098490
MIRT437429	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	24098490
MIRT493620	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT493619	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT493618	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT493617	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT493616	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT493615	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT020449	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT493614	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT493613	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT493612	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT493611	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT493609	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT493610	hsa-miR-3120-3p	PAR-CLIP	21572407
MIRT493608	hsa-miR-5586-3p	PAR-CLIP	21572407
MIRT493607	hsa-miR-520g-3p	PAR-CLIP	21572407
MIRT493606	hsa-miR-520h	PAR-CLIP	21572407
MIRT493605	hsa-miR-759	PAR-CLIP	21572407
MIRT493604	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT493603	hsa-miR-3150b-3p	PAR-CLIP	21572407
MIRT493602	hsa-miR-4784	PAR-CLIP	21572407
MIRT493601	hsa-miR-4689	PAR-CLIP	21572407
MIRT493600	hsa-miR-6858-5p	PAR-CLIP	21572407
MIRT493620	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT493619	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT493618	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT493617	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT493616	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT493615	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT020449	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT493614	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT493613	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT493612	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT493611	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT493609	hsa-miR-4797-5p	PAR-CLIP	23446348
MIRT493610	hsa-miR-3120-3p	PAR-CLIP	23446348
MIRT493608	hsa-miR-5586-3p	PAR-CLIP	23446348
MIRT493607	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT493606	hsa-miR-520h	PAR-CLIP	23446348
MIRT493605	hsa-miR-759	PAR-CLIP	23446348
MIRT493604	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT493603	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT493602	hsa-miR-4784	PAR-CLIP	23446348
MIRT493601	hsa-miR-4689	PAR-CLIP	23446348
MIRT493600	hsa-miR-6858-5p	PAR-CLIP	23446348
MIRT493620	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT493619	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT493618	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT493617	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT493616	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT493615	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT020449	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT493614	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT493613	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT493612	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT493611	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT493609	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT493610	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT493608	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT493607	hsa-miR-520g-3p	PAR-CLIP	23592263
MIRT493606	hsa-miR-520h	PAR-CLIP	23592263
MIRT493605	hsa-miR-759	PAR-CLIP	23592263
MIRT493604	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT493603	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT493602	hsa-miR-4784	PAR-CLIP	23592263
MIRT493601	hsa-miR-4689	PAR-CLIP	23592263
MIRT493600	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT732267	hsa-miR-27b-3p	Luciferase reporter assay, Western blot	27363334
MIRT732267	hsa-miR-27b-3p	Luciferase reporter assay, Western blot	27363334
MIRT493620	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT493619	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT493618	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT493617	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT493616	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT493615	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT020449	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT493614	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT493613	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT493612	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT493611	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT493609	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT493610	hsa-miR-3120-3p	PAR-CLIP	21572407
MIRT493608	hsa-miR-5586-3p	PAR-CLIP	21572407
MIRT493607	hsa-miR-520g-3p	PAR-CLIP	21572407
MIRT493606	hsa-miR-520h	PAR-CLIP	21572407
MIRT493605	hsa-miR-759	PAR-CLIP	21572407
MIRT493604	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT493603	hsa-miR-3150b-3p	PAR-CLIP	21572407
MIRT493602	hsa-miR-4784	PAR-CLIP	21572407
MIRT493601	hsa-miR-4689	PAR-CLIP	21572407
MIRT493600	hsa-miR-6858-5p	PAR-CLIP	21572407
MIRT493620	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT493619	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT493618	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT493617	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT493616	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT493615	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT020449	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT493614	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT493613	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT493612	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT493611	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT493609	hsa-miR-4797-5p	PAR-CLIP	23446348
MIRT493610	hsa-miR-3120-3p	PAR-CLIP	23446348
MIRT493608	hsa-miR-5586-3p	PAR-CLIP	23446348
MIRT493607	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT493606	hsa-miR-520h	PAR-CLIP	23446348
MIRT493605	hsa-miR-759	PAR-CLIP	23446348
MIRT493604	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT493603	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT493602	hsa-miR-4784	PAR-CLIP	23446348
MIRT493601	hsa-miR-4689	PAR-CLIP	23446348
MIRT493600	hsa-miR-6858-5p	PAR-CLIP	23446348
MIRT493620	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT493619	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT493618	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT493617	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT493616	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT493615	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT020449	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT493614	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT493613	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT493612	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT493611	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT493609	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT493610	hsa-miR-3120-3p	PAR-CLIP	23592263
MIRT493608	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT493607	hsa-miR-520g-3p	PAR-CLIP	23592263
MIRT493606	hsa-miR-520h	PAR-CLIP	23592263
MIRT493605	hsa-miR-759	PAR-CLIP	23592263
MIRT493604	hsa-miR-545-3p	PAR-CLIP	23592263
MIRT493603	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT493602	hsa-miR-4784	PAR-CLIP	23592263
MIRT493601	hsa-miR-4689	PAR-CLIP	23592263
MIRT493600	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT437429	hsa-miR-205-5p	Microarray, qRT-PCR	35816043
MIRT1049281	hsa-miR-106a	CLIP-seq
MIRT1049282	hsa-miR-106b	CLIP-seq
MIRT1049283	hsa-miR-1179	CLIP-seq
MIRT1049284	hsa-miR-122	CLIP-seq
MIRT1049285	hsa-miR-1228	CLIP-seq
MIRT1049286	hsa-miR-1275	CLIP-seq
MIRT1049287	hsa-miR-127-5p	CLIP-seq
MIRT1049288	hsa-miR-129-3p	CLIP-seq
MIRT1049289	hsa-miR-1297	CLIP-seq
MIRT1049290	hsa-miR-1321	CLIP-seq
MIRT1049291	hsa-miR-140-3p	CLIP-seq
MIRT1049292	hsa-miR-17	CLIP-seq
MIRT1049293	hsa-miR-200b	CLIP-seq
MIRT1049294	hsa-miR-200c	CLIP-seq
MIRT1049295	hsa-miR-2052	CLIP-seq
MIRT1049296	hsa-miR-2054	CLIP-seq
MIRT1049297	hsa-miR-20a	CLIP-seq
MIRT1049298	hsa-miR-20b	CLIP-seq
MIRT1049299	hsa-miR-2116	CLIP-seq
MIRT1049300	hsa-miR-2355-3p	CLIP-seq
MIRT1049301	hsa-miR-26a	CLIP-seq
MIRT1049302	hsa-miR-26b	CLIP-seq
MIRT1049303	hsa-miR-3148	CLIP-seq
MIRT1049304	hsa-miR-3160-5p	CLIP-seq
MIRT1049305	hsa-miR-3162-5p	CLIP-seq
MIRT1049306	hsa-miR-3167	CLIP-seq
MIRT1049307	hsa-miR-3168	CLIP-seq
MIRT1049308	hsa-miR-3171	CLIP-seq
MIRT1049309	hsa-miR-320a	CLIP-seq
MIRT1049310	hsa-miR-320b	CLIP-seq
MIRT1049311	hsa-miR-320c	CLIP-seq
MIRT1049312	hsa-miR-320d	CLIP-seq
MIRT1049313	hsa-miR-3613-3p	CLIP-seq
MIRT1049314	hsa-miR-3616-3p	CLIP-seq
MIRT1049315	hsa-miR-362-5p	CLIP-seq
MIRT1049316	hsa-miR-3653	CLIP-seq
MIRT1049317	hsa-miR-3658	CLIP-seq
MIRT1049318	hsa-miR-3664-3p	CLIP-seq
MIRT1049319	hsa-miR-3671	CLIP-seq
MIRT1049320	hsa-miR-371-5p	CLIP-seq
MIRT1049321	hsa-miR-371b-5p	CLIP-seq
MIRT1049322	hsa-miR-375	CLIP-seq
MIRT1049323	hsa-miR-380	CLIP-seq
MIRT1049324	hsa-miR-4273	CLIP-seq
MIRT1049325	hsa-miR-429	CLIP-seq
MIRT1049326	hsa-miR-4291	CLIP-seq
MIRT1049327	hsa-miR-4310	CLIP-seq
MIRT1049328	hsa-miR-4317	CLIP-seq
MIRT1049329	hsa-miR-4419a	CLIP-seq
MIRT1049330	hsa-miR-4426	CLIP-seq
MIRT1049331	hsa-miR-4429	CLIP-seq
MIRT1049332	hsa-miR-4447	CLIP-seq
MIRT1049333	hsa-miR-4465	CLIP-seq
MIRT1049334	hsa-miR-4472	CLIP-seq
MIRT1049335	hsa-miR-4481	CLIP-seq
MIRT1049336	hsa-miR-4510	CLIP-seq
MIRT1049337	hsa-miR-452	CLIP-seq
MIRT1049338	hsa-miR-4525	CLIP-seq
MIRT1049339	hsa-miR-4645-3p	CLIP-seq
MIRT1049340	hsa-miR-4646-3p	CLIP-seq
MIRT1049341	hsa-miR-4647	CLIP-seq
MIRT1049342	hsa-miR-4662a-5p	CLIP-seq
MIRT1049343	hsa-miR-4662b	CLIP-seq
MIRT1049344	hsa-miR-4665-5p	CLIP-seq
MIRT1049345	hsa-miR-4666-3p	CLIP-seq
MIRT1049346	hsa-miR-4668-5p	CLIP-seq
MIRT1049347	hsa-miR-4676-3p	CLIP-seq
MIRT1049348	hsa-miR-4677-5p	CLIP-seq
MIRT1049349	hsa-miR-4687-5p	CLIP-seq
MIRT1049350	hsa-miR-4693-3p	CLIP-seq
MIRT1049351	hsa-miR-4694-3p	CLIP-seq
MIRT1049352	hsa-miR-4701-5p	CLIP-seq
MIRT1049353	hsa-miR-4709-3p	CLIP-seq
MIRT1049354	hsa-miR-4721	CLIP-seq
MIRT1049355	hsa-miR-4723-5p	CLIP-seq
MIRT1049356	hsa-miR-4729	CLIP-seq
MIRT1049357	hsa-miR-4739	CLIP-seq
MIRT1049358	hsa-miR-4745-5p	CLIP-seq
MIRT1049359	hsa-miR-4753-3p	CLIP-seq
MIRT1049360	hsa-miR-4756-5p	CLIP-seq
MIRT1049361	hsa-miR-4768-5p	CLIP-seq
MIRT1049362	hsa-miR-4788	CLIP-seq
MIRT1049363	hsa-miR-4799-5p	CLIP-seq
MIRT1049364	hsa-miR-500b	CLIP-seq
MIRT1049365	hsa-miR-501-5p	CLIP-seq
MIRT1049366	hsa-miR-510	CLIP-seq
MIRT1049367	hsa-miR-513c	CLIP-seq
MIRT1049368	hsa-miR-514b-5p	CLIP-seq
MIRT1049369	hsa-miR-515-3p	CLIP-seq
MIRT1049370	hsa-miR-515-5p	CLIP-seq
MIRT1049371	hsa-miR-519a	CLIP-seq
MIRT1049372	hsa-miR-519d	CLIP-seq
MIRT1049373	hsa-miR-519e	CLIP-seq
MIRT1049374	hsa-miR-520d-5p	CLIP-seq
MIRT1049375	hsa-miR-520g	CLIP-seq
MIRT1049376	hsa-miR-522	CLIP-seq
MIRT1049377	hsa-miR-524-5p	CLIP-seq
MIRT1049378	hsa-miR-545	CLIP-seq
MIRT1049379	hsa-miR-548c-3p	CLIP-seq
MIRT1049380	hsa-miR-562	CLIP-seq
MIRT1049381	hsa-miR-579	CLIP-seq
MIRT1049382	hsa-miR-588	CLIP-seq
MIRT1049383	hsa-miR-625	CLIP-seq
MIRT1049384	hsa-miR-628-5p	CLIP-seq
MIRT1049385	hsa-miR-642b	CLIP-seq
MIRT1049386	hsa-miR-668	CLIP-seq
MIRT1049387	hsa-miR-671-5p	CLIP-seq
MIRT1049388	hsa-miR-876-5p	CLIP-seq
MIRT1049389	hsa-miR-877	CLIP-seq
MIRT1049390	hsa-miR-885-3p	CLIP-seq
MIRT1049391	hsa-miR-922	CLIP-seq
MIRT1049392	hsa-miR-93	CLIP-seq
MIRT1549565	hsa-miR-125a-5p	CLIP-seq
MIRT1549566	hsa-miR-125b	CLIP-seq
MIRT1549567	hsa-miR-150	CLIP-seq
MIRT1549568	hsa-miR-4319	CLIP-seq
MIRT1549569	hsa-miR-4713-5p	CLIP-seq
MIRT1549570	hsa-miR-532-3p	CLIP-seq
MIRT1549571	hsa-miR-548v	CLIP-seq
MIRT1549572	hsa-miR-610	CLIP-seq
MIRT1921214	hsa-miR-1291	CLIP-seq
MIRT1921215	hsa-miR-3189-3p	CLIP-seq
MIRT1921216	hsa-miR-328	CLIP-seq
MIRT1049315	hsa-miR-362-5p	CLIP-seq
MIRT1049364	hsa-miR-500b	CLIP-seq
MIRT1921217	hsa-miR-587	CLIP-seq
MIRT1049281	hsa-miR-106a	CLIP-seq
MIRT1049282	hsa-miR-106b	CLIP-seq
MIRT1049285	hsa-miR-1228	CLIP-seq
MIRT2011295	hsa-miR-145	CLIP-seq
MIRT1049292	hsa-miR-17	CLIP-seq
MIRT1049297	hsa-miR-20a	CLIP-seq
MIRT1049298	hsa-miR-20b	CLIP-seq
MIRT2011296	hsa-miR-2278	CLIP-seq
MIRT2011297	hsa-miR-2355-5p	CLIP-seq
MIRT2011298	hsa-miR-30a	CLIP-seq
MIRT2011299	hsa-miR-30b	CLIP-seq
MIRT2011300	hsa-miR-30c	CLIP-seq
MIRT2011301	hsa-miR-30d	CLIP-seq
MIRT2011302	hsa-miR-30e	CLIP-seq
MIRT2011303	hsa-miR-3143	CLIP-seq
MIRT2011304	hsa-miR-3180-5p	CLIP-seq
MIRT2011305	hsa-miR-338-5p	CLIP-seq
MIRT1049313	hsa-miR-3613-3p	CLIP-seq
MIRT1049314	hsa-miR-3616-3p	CLIP-seq
MIRT1049316	hsa-miR-3653	CLIP-seq
MIRT1049317	hsa-miR-3658	CLIP-seq
MIRT2011306	hsa-miR-3667-3p	CLIP-seq
MIRT1049319	hsa-miR-3671	CLIP-seq
MIRT1049320	hsa-miR-371-5p	CLIP-seq
MIRT1049321	hsa-miR-371b-5p	CLIP-seq
MIRT2011307	hsa-miR-3910	CLIP-seq
MIRT2011308	hsa-miR-4286	CLIP-seq
MIRT2011309	hsa-miR-4312	CLIP-seq
MIRT2011310	hsa-miR-4448	CLIP-seq
MIRT2011311	hsa-miR-4495	CLIP-seq
MIRT2011312	hsa-miR-4517	CLIP-seq
MIRT1049351	hsa-miR-4694-3p	CLIP-seq
MIRT1049352	hsa-miR-4701-5p	CLIP-seq
MIRT1049354	hsa-miR-4721	CLIP-seq
MIRT2011313	hsa-miR-4777-5p	CLIP-seq
MIRT2011314	hsa-miR-499-3p	CLIP-seq
MIRT2011315	hsa-miR-499a-3p	CLIP-seq
MIRT2011316	hsa-miR-505	CLIP-seq
MIRT1049367	hsa-miR-513c	CLIP-seq
MIRT1049368	hsa-miR-514b-5p	CLIP-seq
MIRT2011317	hsa-miR-518d-5p	CLIP-seq
MIRT1049371	hsa-miR-519a	CLIP-seq
MIRT2011318	hsa-miR-519b-5p	CLIP-seq
MIRT2011319	hsa-miR-519c-5p	CLIP-seq
MIRT1049372	hsa-miR-519d	CLIP-seq
MIRT2011320	hsa-miR-520c-5p	CLIP-seq
MIRT1049375	hsa-miR-520g	CLIP-seq
MIRT1049376	hsa-miR-522	CLIP-seq
MIRT2011321	hsa-miR-526a	CLIP-seq
MIRT2011322	hsa-miR-532-5p	CLIP-seq
MIRT2011323	hsa-miR-543	CLIP-seq
MIRT1049378	hsa-miR-545	CLIP-seq
MIRT2011324	hsa-miR-548ae	CLIP-seq
MIRT2011325	hsa-miR-548aj	CLIP-seq
MIRT2011326	hsa-miR-548am	CLIP-seq
MIRT2011327	hsa-miR-548x	CLIP-seq
MIRT1049382	hsa-miR-588	CLIP-seq
MIRT1049385	hsa-miR-642b	CLIP-seq
MIRT2011328	hsa-miR-876-3p	CLIP-seq
MIRT1049392	hsa-miR-93	CLIP-seq
MIRT1049281	hsa-miR-106a	CLIP-seq
MIRT1049282	hsa-miR-106b	CLIP-seq
MIRT1049283	hsa-miR-1179	CLIP-seq
MIRT1049284	hsa-miR-122	CLIP-seq
MIRT1049285	hsa-miR-1228	CLIP-seq
MIRT1549565	hsa-miR-125a-5p	CLIP-seq
MIRT1549566	hsa-miR-125b	CLIP-seq
MIRT1049287	hsa-miR-127-5p	CLIP-seq
MIRT2243493	hsa-miR-128	CLIP-seq
MIRT2243494	hsa-miR-1294	CLIP-seq
MIRT1049290	hsa-miR-1321	CLIP-seq
MIRT2243495	hsa-miR-1324	CLIP-seq
MIRT2011295	hsa-miR-145	CLIP-seq
MIRT2243496	hsa-miR-148a	CLIP-seq
MIRT2243497	hsa-miR-148b	CLIP-seq
MIRT1549567	hsa-miR-150	CLIP-seq
MIRT2243498	hsa-miR-152	CLIP-seq
MIRT1049292	hsa-miR-17	CLIP-seq
MIRT1049297	hsa-miR-20a	CLIP-seq
MIRT1049298	hsa-miR-20b	CLIP-seq
MIRT1049299	hsa-miR-2116	CLIP-seq
MIRT2011296	hsa-miR-2278	CLIP-seq
MIRT1049300	hsa-miR-2355-3p	CLIP-seq
MIRT2011297	hsa-miR-2355-5p	CLIP-seq
MIRT2243499	hsa-miR-296-5p	CLIP-seq
MIRT2243500	hsa-miR-3064-3p	CLIP-seq
MIRT2011298	hsa-miR-30a	CLIP-seq
MIRT2011299	hsa-miR-30b	CLIP-seq
MIRT2011300	hsa-miR-30c	CLIP-seq
MIRT2011301	hsa-miR-30d	CLIP-seq
MIRT2011302	hsa-miR-30e	CLIP-seq
MIRT2243501	hsa-miR-3124-3p	CLIP-seq
MIRT2243502	hsa-miR-3126-3p	CLIP-seq
MIRT2243503	hsa-miR-3127-5p	CLIP-seq
MIRT2011303	hsa-miR-3143	CLIP-seq
MIRT2243504	hsa-miR-3155	CLIP-seq
MIRT2243505	hsa-miR-3155b	CLIP-seq
MIRT1049305	hsa-miR-3162-5p	CLIP-seq
MIRT2243506	hsa-miR-3163	CLIP-seq
MIRT1049306	hsa-miR-3167	CLIP-seq
MIRT2011304	hsa-miR-3180-5p	CLIP-seq
MIRT2243507	hsa-miR-324-5p	CLIP-seq
MIRT1921216	hsa-miR-328	CLIP-seq
MIRT2243508	hsa-miR-329	CLIP-seq
MIRT2011305	hsa-miR-338-5p	CLIP-seq
MIRT2243509	hsa-miR-342-5p	CLIP-seq
MIRT2243510	hsa-miR-3591-5p	CLIP-seq
MIRT1049313	hsa-miR-3613-3p	CLIP-seq
MIRT2243511	hsa-miR-362-3p	CLIP-seq
MIRT2243512	hsa-miR-3662	CLIP-seq
MIRT1049318	hsa-miR-3664-3p	CLIP-seq
MIRT2011306	hsa-miR-3667-3p	CLIP-seq
MIRT2243513	hsa-miR-3676	CLIP-seq
MIRT1049320	hsa-miR-371-5p	CLIP-seq
MIRT1049322	hsa-miR-375	CLIP-seq
MIRT2243514	hsa-miR-3907	CLIP-seq
MIRT2011307	hsa-miR-3910	CLIP-seq
MIRT1049324	hsa-miR-4273	CLIP-seq
MIRT2243515	hsa-miR-4275	CLIP-seq
MIRT2011308	hsa-miR-4286	CLIP-seq
MIRT1049326	hsa-miR-4291	CLIP-seq
MIRT2243516	hsa-miR-4302	CLIP-seq
MIRT1049327	hsa-miR-4310	CLIP-seq
MIRT2011309	hsa-miR-4312	CLIP-seq
MIRT1549568	hsa-miR-4319	CLIP-seq
MIRT1049329	hsa-miR-4419a	CLIP-seq
MIRT2243517	hsa-miR-4420	CLIP-seq
MIRT1049330	hsa-miR-4426	CLIP-seq
MIRT1049332	hsa-miR-4447	CLIP-seq
MIRT2011310	hsa-miR-4448	CLIP-seq
MIRT2243518	hsa-miR-4457	CLIP-seq
MIRT1049334	hsa-miR-4472	CLIP-seq
MIRT1049335	hsa-miR-4481	CLIP-seq
MIRT2011311	hsa-miR-4495	CLIP-seq
MIRT2243519	hsa-miR-4504	CLIP-seq
MIRT1049336	hsa-miR-4510	CLIP-seq
MIRT2011312	hsa-miR-4517	CLIP-seq
MIRT1049340	hsa-miR-4646-3p	CLIP-seq
MIRT1049341	hsa-miR-4647	CLIP-seq
MIRT2243520	hsa-miR-4651	CLIP-seq
MIRT1049342	hsa-miR-4662a-5p	CLIP-seq
MIRT1049343	hsa-miR-4662b	CLIP-seq
MIRT2243521	hsa-miR-4664-5p	CLIP-seq
MIRT1049345	hsa-miR-4666-3p	CLIP-seq
MIRT2243522	hsa-miR-4671-5p	CLIP-seq
MIRT2243523	hsa-miR-4677-3p	CLIP-seq
MIRT1049348	hsa-miR-4677-5p	CLIP-seq
MIRT1049350	hsa-miR-4693-3p	CLIP-seq
MIRT1049351	hsa-miR-4694-3p	CLIP-seq
MIRT1049352	hsa-miR-4701-5p	CLIP-seq
MIRT2243524	hsa-miR-4710	CLIP-seq
MIRT1549569	hsa-miR-4713-5p	CLIP-seq
MIRT2243525	hsa-miR-4719	CLIP-seq
MIRT1049356	hsa-miR-4729	CLIP-seq
MIRT1049357	hsa-miR-4739	CLIP-seq
MIRT1049358	hsa-miR-4745-5p	CLIP-seq
MIRT1049360	hsa-miR-4756-5p	CLIP-seq
MIRT2243526	hsa-miR-4768-3p	CLIP-seq
MIRT2243527	hsa-miR-4773	CLIP-seq
MIRT2011313	hsa-miR-4777-5p	CLIP-seq
MIRT1049363	hsa-miR-4799-5p	CLIP-seq
MIRT2243528	hsa-miR-484	CLIP-seq
MIRT2243529	hsa-miR-494	CLIP-seq
MIRT2011314	hsa-miR-499-3p	CLIP-seq
MIRT2011315	hsa-miR-499a-3p	CLIP-seq
MIRT1049366	hsa-miR-510	CLIP-seq
MIRT2243530	hsa-miR-513b	CLIP-seq
MIRT1049369	hsa-miR-515-3p	CLIP-seq
MIRT1049370	hsa-miR-515-5p	CLIP-seq
MIRT2011317	hsa-miR-518d-5p	CLIP-seq
MIRT1049371	hsa-miR-519a	CLIP-seq
MIRT2011318	hsa-miR-519b-5p	CLIP-seq
MIRT2011319	hsa-miR-519c-5p	CLIP-seq
MIRT1049372	hsa-miR-519d	CLIP-seq
MIRT1049373	hsa-miR-519e	CLIP-seq
MIRT2011320	hsa-miR-520c-5p	CLIP-seq
MIRT1049374	hsa-miR-520d-5p	CLIP-seq
MIRT1049375	hsa-miR-520g	CLIP-seq
MIRT1049376	hsa-miR-522	CLIP-seq
MIRT1049377	hsa-miR-524-5p	CLIP-seq
MIRT2011321	hsa-miR-526a	CLIP-seq
MIRT1549570	hsa-miR-532-3p	CLIP-seq
MIRT2011322	hsa-miR-532-5p	CLIP-seq
MIRT2243531	hsa-miR-542-3p	CLIP-seq
MIRT2011323	hsa-miR-543	CLIP-seq
MIRT1049378	hsa-miR-545	CLIP-seq
MIRT2243532	hsa-miR-548an	CLIP-seq
MIRT1549571	hsa-miR-548v	CLIP-seq
MIRT2243533	hsa-miR-570	CLIP-seq
MIRT1049381	hsa-miR-579	CLIP-seq
MIRT2243534	hsa-miR-582-5p	CLIP-seq
MIRT1921217	hsa-miR-587	CLIP-seq
MIRT1049382	hsa-miR-588	CLIP-seq
MIRT2243535	hsa-miR-591	CLIP-seq
MIRT2243536	hsa-miR-608	CLIP-seq
MIRT1549572	hsa-miR-610	CLIP-seq
MIRT2243537	hsa-miR-616	CLIP-seq
MIRT1049385	hsa-miR-642b	CLIP-seq
MIRT2243538	hsa-miR-665	CLIP-seq
MIRT1049386	hsa-miR-668	CLIP-seq
MIRT2243539	hsa-miR-758	CLIP-seq
MIRT2011328	hsa-miR-876-3p	CLIP-seq
MIRT1049388	hsa-miR-876-5p	CLIP-seq
MIRT1049389	hsa-miR-877	CLIP-seq
MIRT1049390	hsa-miR-885-3p	CLIP-seq
MIRT2243540	hsa-miR-885-5p	CLIP-seq
MIRT1049391	hsa-miR-922	CLIP-seq
MIRT1049392	hsa-miR-93	CLIP-seq
MIRT1049281	hsa-miR-106a	CLIP-seq
MIRT1049282	hsa-miR-106b	CLIP-seq
MIRT1049285	hsa-miR-1228	CLIP-seq
MIRT2389064	hsa-miR-1257	CLIP-seq
MIRT2011295	hsa-miR-145	CLIP-seq
MIRT1049292	hsa-miR-17	CLIP-seq
MIRT2389065	hsa-miR-1825	CLIP-seq
MIRT2389066	hsa-miR-199a-5p	CLIP-seq
MIRT2389067	hsa-miR-199b-5p	CLIP-seq
MIRT1049297	hsa-miR-20a	CLIP-seq
MIRT1049298	hsa-miR-20b	CLIP-seq
MIRT2011303	hsa-miR-3143	CLIP-seq
MIRT2011304	hsa-miR-3180-5p	CLIP-seq
MIRT2011306	hsa-miR-3667-3p	CLIP-seq
MIRT2011308	hsa-miR-4286	CLIP-seq
MIRT2011309	hsa-miR-4312	CLIP-seq
MIRT2011310	hsa-miR-4448	CLIP-seq
MIRT2011314	hsa-miR-499-3p	CLIP-seq
MIRT2011315	hsa-miR-499a-3p	CLIP-seq
MIRT1049371	hsa-miR-519a	CLIP-seq
MIRT1049372	hsa-miR-519d	CLIP-seq
MIRT1049374	hsa-miR-520d-5p	CLIP-seq
MIRT1049375	hsa-miR-520g	CLIP-seq
MIRT1049377	hsa-miR-524-5p	CLIP-seq
MIRT2011322	hsa-miR-532-5p	CLIP-seq
MIRT2011323	hsa-miR-543	CLIP-seq
MIRT1049378	hsa-miR-545	CLIP-seq
MIRT1049385	hsa-miR-642b	CLIP-seq
MIRT1049392	hsa-miR-93	CLIP-seq
MIRT1549565	hsa-miR-125a-5p	CLIP-seq
MIRT1549566	hsa-miR-125b	CLIP-seq
MIRT1049287	hsa-miR-127-5p	CLIP-seq
MIRT2243493	hsa-miR-128	CLIP-seq
MIRT1049289	hsa-miR-1297	CLIP-seq
MIRT2243495	hsa-miR-1324	CLIP-seq
MIRT2011295	hsa-miR-145	CLIP-seq
MIRT2243496	hsa-miR-148a	CLIP-seq
MIRT2243497	hsa-miR-148b	CLIP-seq
MIRT1549567	hsa-miR-150	CLIP-seq
MIRT2243498	hsa-miR-152	CLIP-seq
MIRT2011296	hsa-miR-2278	CLIP-seq
MIRT1049300	hsa-miR-2355-3p	CLIP-seq
MIRT2011297	hsa-miR-2355-5p	CLIP-seq
MIRT2546723	hsa-miR-2467-3p	CLIP-seq
MIRT1049301	hsa-miR-26a	CLIP-seq
MIRT1049302	hsa-miR-26b	CLIP-seq
MIRT2546724	hsa-miR-27a	CLIP-seq
MIRT2546725	hsa-miR-27b	CLIP-seq
MIRT2011303	hsa-miR-3143	CLIP-seq
MIRT2546726	hsa-miR-3158-5p	CLIP-seq
MIRT2011306	hsa-miR-3667-3p	CLIP-seq
MIRT1049319	hsa-miR-3671	CLIP-seq
MIRT2546727	hsa-miR-3678-3p	CLIP-seq
MIRT1049320	hsa-miR-371-5p	CLIP-seq
MIRT1049321	hsa-miR-371b-5p	CLIP-seq
MIRT2546728	hsa-miR-377	CLIP-seq
MIRT2011307	hsa-miR-3910	CLIP-seq
MIRT2546729	hsa-miR-421	CLIP-seq
MIRT2546730	hsa-miR-4252	CLIP-seq
MIRT2243515	hsa-miR-4275	CLIP-seq
MIRT2011308	hsa-miR-4286	CLIP-seq
MIRT2546731	hsa-miR-4313	CLIP-seq
MIRT1549568	hsa-miR-4319	CLIP-seq
MIRT1049330	hsa-miR-4426	CLIP-seq
MIRT2011310	hsa-miR-4448	CLIP-seq
MIRT1049333	hsa-miR-4465	CLIP-seq
MIRT1049340	hsa-miR-4646-3p	CLIP-seq
MIRT1049341	hsa-miR-4647	CLIP-seq
MIRT1049343	hsa-miR-4662b	CLIP-seq
MIRT1049351	hsa-miR-4694-3p	CLIP-seq
MIRT2546732	hsa-miR-4709-5p	CLIP-seq
MIRT1549569	hsa-miR-4713-5p	CLIP-seq
MIRT2011313	hsa-miR-4777-5p	CLIP-seq
MIRT2011316	hsa-miR-505	CLIP-seq
MIRT1049367	hsa-miR-513c	CLIP-seq
MIRT1049368	hsa-miR-514b-5p	CLIP-seq
MIRT2011317	hsa-miR-518d-5p	CLIP-seq
MIRT2011318	hsa-miR-519b-5p	CLIP-seq
MIRT2011319	hsa-miR-519c-5p	CLIP-seq
MIRT2011320	hsa-miR-520c-5p	CLIP-seq
MIRT1049376	hsa-miR-522	CLIP-seq
MIRT2011321	hsa-miR-526a	CLIP-seq
MIRT1549570	hsa-miR-532-3p	CLIP-seq
MIRT2011323	hsa-miR-543	CLIP-seq
MIRT2243532	hsa-miR-548an	CLIP-seq
MIRT1549571	hsa-miR-548v	CLIP-seq
MIRT1049380	hsa-miR-562	CLIP-seq
MIRT2546733	hsa-miR-576-3p	CLIP-seq
MIRT2546734	hsa-miR-592	CLIP-seq
MIRT2546735	hsa-miR-597	CLIP-seq
MIRT1549572	hsa-miR-610	CLIP-seq
MIRT1049385	hsa-miR-642b	CLIP-seq
MIRT1049386	hsa-miR-668	CLIP-seq
MIRT1049390	hsa-miR-885-3p	CLIP-seq
MIRT1049391	hsa-miR-922	CLIP-seq
MIRT1549565	hsa-miR-125a-5p	CLIP-seq
MIRT1549566	hsa-miR-125b	CLIP-seq
MIRT1049287	hsa-miR-127-5p	CLIP-seq
MIRT2243493	hsa-miR-128	CLIP-seq
MIRT2243496	hsa-miR-148a	CLIP-seq
MIRT2243497	hsa-miR-148b	CLIP-seq
MIRT1549567	hsa-miR-150	CLIP-seq
MIRT2243498	hsa-miR-152	CLIP-seq
MIRT2011296	hsa-miR-2278	CLIP-seq
MIRT1049300	hsa-miR-2355-3p	CLIP-seq
MIRT2011297	hsa-miR-2355-5p	CLIP-seq
MIRT2546723	hsa-miR-2467-3p	CLIP-seq
MIRT2546724	hsa-miR-27a	CLIP-seq
MIRT2546725	hsa-miR-27b	CLIP-seq
MIRT2546726	hsa-miR-3158-5p	CLIP-seq
MIRT2011305	hsa-miR-338-5p	CLIP-seq
MIRT2546727	hsa-miR-3678-3p	CLIP-seq
MIRT2011307	hsa-miR-3910	CLIP-seq
MIRT2546729	hsa-miR-421	CLIP-seq
MIRT2011308	hsa-miR-4286	CLIP-seq
MIRT2546731	hsa-miR-4313	CLIP-seq
MIRT1549568	hsa-miR-4319	CLIP-seq
MIRT1049330	hsa-miR-4426	CLIP-seq
MIRT2011312	hsa-miR-4517	CLIP-seq
MIRT1049340	hsa-miR-4646-3p	CLIP-seq
MIRT1049341	hsa-miR-4647	CLIP-seq
MIRT1049343	hsa-miR-4662b	CLIP-seq
MIRT1049351	hsa-miR-4694-3p	CLIP-seq
MIRT2546732	hsa-miR-4709-5p	CLIP-seq
MIRT1549569	hsa-miR-4713-5p	CLIP-seq
MIRT2011313	hsa-miR-4777-5p	CLIP-seq
MIRT2011316	hsa-miR-505	CLIP-seq
MIRT2011317	hsa-miR-518d-5p	CLIP-seq
MIRT2011318	hsa-miR-519b-5p	CLIP-seq
MIRT2011319	hsa-miR-519c-5p	CLIP-seq
MIRT2011320	hsa-miR-520c-5p	CLIP-seq
MIRT1049376	hsa-miR-522	CLIP-seq
MIRT2011321	hsa-miR-526a	CLIP-seq
MIRT1549570	hsa-miR-532-3p	CLIP-seq
MIRT2243532	hsa-miR-548an	CLIP-seq
MIRT1549571	hsa-miR-548v	CLIP-seq
MIRT1549572	hsa-miR-610	CLIP-seq
MIRT1049390	hsa-miR-885-3p	CLIP-seq
MIRT1049391	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000400	Function	Four-way junction DNA binding	ISS
GO:0002376	Process	Immune system process	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	ISS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21044950, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006310	Process	DNA recombination	ISS
GO:0008301	Function	DNA binding, bending	ISS
GO:0008301	Function	DNA binding, bending	TAS	9598312
GO:0032392	Process	DNA geometric change	ISS
GO:0045087	Process	Innate immune response	IEA
GO:0045578	Process	Negative regulation of B cell differentiation	IEA
GO:0045638	Process	Negative regulation of myeloid cell differentiation	IEA

Other IDs

• MIM: 300193
• HGNC: 5004
• e!Ensembl: ENSG00000029993

Protein

• UniProt ID: O15347
• Protein name: High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)
• Protein function: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend
• PDB: 2EQZ, 2YQI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09011	HMG_box_2	6 → 79	HMG-box domain	Domain
  PF00505	HMG_box	93 → 161	HMG (high mobility group) box	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in placenta.
• Sequence:

  MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSGKEKSKF
  DEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISI
  GDVAKKLGEMWNNLNDSEKQPYITKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKV
  EEEDEEEEEEEEEEEEEEDE

• Sequence length: 200

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
HMGB3-related disorder	Benign; Likely benign	rs782021512, rs782301597, rs782085206	RCV003919593 RCV003911737 RCV003901402 RCV003936827
X-linked colobomatous microphthalmia-microcephaly-intellectual disability-short stature syndrome	Uncertain significance	rs431825172	RCV000128635

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	36397035
Autistic Disorder	Associate	32291385
Breast Neoplasms	Inhibit	22655796
Breast Neoplasms	Associate	24098490, 31755218, 36267313, 37338518
Breast Neoplasms	Stimulate	31773719
Carcinoma Hepatocellular	Associate	30343649
Carcinoma Non Small Cell Lung	Associate	16619573, 23609034, 30446524
Carcinoma Ovarian Epithelial	Associate	37328851
Carcinoma Pancreatic Ductal	Associate	39684631
Carcinoma Squamous Cell	Associate	32871048
Cell Transformation Neoplastic	Associate	25755721
Colorectal Neoplasms	Stimulate	28678825
Endometrial Neoplasms	Associate	35778922
Esophageal Neoplasms	Associate	33960364
Esophageal Squamous Cell Carcinoma	Associate	25755721
Glioblastoma	Associate	31858556
Hypoxia	Stimulate	38197217
Leukemia	Associate	25095979
Lung Neoplasms	Associate	16619573
Lymphatic Metastasis	Stimulate	23326140, 25647262, 28678825, 37328851, 38197217
Lymphatic Metastasis	Associate	23609034, 25095979, 35778922
Myopia	Associate	37749571
Nasopharyngeal Carcinoma	Associate	32131767
Neoplasm Metastasis	Associate	35778922, 37328851
Neoplasms	Associate	22655796, 23609034, 24098490, 25095979, 25097177, 27774979, 36397035, 38149239
Neoplasms	Stimulate	25647262, 25755721, 37328851, 38197217
Ovarian Neoplasms	Associate	37328851
Progressive hearing loss stapes fixation	Associate	37749571
Small Cell Lung Carcinoma	Associate	16619573, 38181741
Squamous Cell Carcinoma of Head and Neck	Associate	35886008
Stomach Neoplasms	Associate	23326140, 24338397, 25095979, 27774979, 28678825, 30343649, 35416122
Thyroid Cancer Papillary	Associate	38197217
Thyroid Neoplasms	Associate	38197217
Urinary Bladder Neoplasms	Associate	25647262, 28678825